Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Furukawa, Koji; Abumiya, Takeo; Sakai, Keiji; Hirano, Michiyo; Osanai, Toshiya; Shichinohe, Hideo; Nakayama, Naoki; Kazumata, Ken; Hida, Kazutoshi; Houkin, Kiyohiro

doi:10.1016/j.jstrokecerebrovasdis.2016.07.031

Cited by 62 publications

(59 citation statements)

References 30 publications

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“…2,3,5 Several studies have demonstrated associations between BV and ischemic stroke. 1,2,6 BV measurements are reportedly higher in lacunar stroke than in other stroke subtypes. Increased BV may impair microvascular tissue perfusion and be related to the pathomechanisms in lacunar stroke.…”

Section: Introductionmentioning

confidence: 84%

“…17 Recent studies, however, suggest that BV is significantly higher in lacunar stroke. 1,2 BV is dependent upon the aggregation of RBCs in small vessels at a low shear rate, equivalent to DBV. 18 Since DBV has a greater impact on the tissue perfusion of small vessels than SBV, DBV can be more likely to influence cerebral SVD.…”

Section: Discussionmentioning

confidence: 99%

“…Blood viscosity (BV) is the measurement of resistance of blood to flow and is an important rheological factor. [1][2][3] Characterized by blood thickness and stickiness, BV is associated with elevated concentrations of blood cells and plasma components, and low deformability and high aggregability of erythrocytes. 3,4 BV plays an essential role in the occurrence of vascular disease.…”

Section: Introductionmentioning

confidence: 99%

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Middle Cerebral Artery Pulsatility Is Highly Associated with Systemic Blood Viscosity in Acute Ischemic Stroke within 24 Hours of Symptom Onset

Han

Park

Baik

et al. 2019

J Neurosonol Neuroimag

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Background: Though blood viscosity (BV) is the major factor influencing pulsatility index (PI), it is unknown whether PI is related with BV in acute ischemic stroke. We explored the association between transcranial Doppler (TCD) PI and BV in acute ischemic stroke patient. Methods: Between January 2018 and December 2018, patients aged 40 years or older with an ischemic stroke or transient ischemic attack within 24 hours of symptom onset were recruited for the study. The scanning capillary-tube viscometer was used to assess whole blood viscosity. Doppler signals showing the highest mean flow velocity were used for PI calculation. Results: A total of 125 patients were enrolled for the study. The most frequent stroke subtype was lacunar stroke (42%), followed by stroke of undetermined etiology negative work-up (29%), and large artery atherosclerosis (19%). The mean middle cerebral artery (mMCA) PI was significantly associated with BV. Age, diabetes and BV were associated with mMCA PI, suggesting that increased mMCA PI is associated with old age, presence of diabetes, and increased BV. Conclusion: Pulsatility of MCA is highly associated with BV in acute ischemic stroke patient within 24 hours of symptom onset. Our findings indicate that TCD PI may be a useful non-invasive imaging modality for exploring the viscosity of cerebral vessels, which in turn is related to systemic BV.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Middle Cerebral Artery Pulsatility Is Highly Associated with Systemic Blood Viscosity in Acute Ischemic Stroke within 24 Hours of Symptom Onset

Han

Park

Baik

et al. 2019

J Neurosonol Neuroimag

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“…The ESR value obtained from this comparison showed that the mean value of EDTA anticoagulated blood (57.90 mm/h) was greater than that of TSC blood (50.99 mm/h) by 6.91 mm/h. This may be because EDTA increases rouleaux formation more than TSC, leading to increases in ESR in EDTA blood, or it might be due to a difference in viscosity, where citrated blood may be less viscous than EDTA blood resulting in lower ESR values [34][35][36]. This observation corresponds to the result reported from Tehran University, Iran, and stated that there was a significant difference between the results of ESR tests which used two anticoagulants [37].…”

Section: Discussionmentioning

confidence: 99%

A comparison of erythrocyte sedimentation rates of bloods anticoagulated with trisodium citrate and EDTA among TB presumptive patients at the University of Gondar comprehensive specialized hospital, northwest Ethiopia

et al. 2020

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Objective: The purpose of this study was comparing the erythrocyte sedimentation rate (ESR) results of trisodium citrate (TSC) and ethylene diamine tetra-acetic acid (EDTA) anticoagulants. A comparative cross-sectional study was conducted at the University of Gondar specialized referral hospital, northwest Ethiopia. A total of 70 TB presumptive participants were recruited. From each of the 70 participants of the study, 3 and 1.6 ml of blood was collected in EDTA tubes and 0.4 ml of trisodium Citrate anticoagulant containing test tubes, respectively. Results: The mean ± SD values of ESR were 57.9 ± 41.45 mm/h in EDTA and 50.99 ± 43.5 mm/h in TSC anticoagulated blood. The mean difference of ESR values between EDTA and TSC blood (6.91 ± 13.66 mm/h) was statistically significant. The Mean ± SD of ESR values using EDTA and TSC in males were 59.57 ± 42.31 and 53.57 ± 44.61 mm/h while for females it was 54.71 ± 40.44 and 46.04 ± 41.82 mm/h, respectively. The study indicated that there was a significant difference between ESR values with EDTA and TSC anticoagulants.

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“…Actually, plasma fibrinogen played a major determinant in platelet aggregation and blood viscosity, whereas high blood viscosity led to blood stagnation and then promoted thrombosis, resulting in the development of ischemic stroke. [54,55] So evaluating the effect of puerarin injection on blood rheology indexes and fibrinogen was important. Moreover, our enrolled sample size was much larger and we focused on acute ischemic stroke treatment, whereas they included acute and chronic ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of puerarin injection in curing acute ischemic stroke

Zheng

Mei

et al. 2017

Medicine

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Background:Previous studies indicated that the puerarin injection has been widely employed in China for the treatment of acute ischemic stroke. We aim to evaluate the efficacy and safety of the puerarin injection for the treatment of acute ischemic stroke.Methods:A systematic literature search was performed in PUBMED, EMBASE, SPRINGER LINK, Scopus, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Journals Database, Wanfang database and the China Biological Medicine database before November 2016, randomized controlled clinical trials (RCTs) of puerarin injection treating acute ischemic stroke were included. In addition, we searched reference lists of relevant retrieved articles. Two authors extracted data independently. The effective rate, the neurologic deficit score, the blood rheology indexes, and fibrinogen were assessed and analyzed by the Review Manager 5.3 software. The continuous variables were expressed as MD with 95% CI and dichotomous data used RR or ORs. Adverse reactions related to the puerarin injection were also examined.Results:Thirty-five RCTs with a total of 3224 participants were identified in the meta-analysis. The combined results of 32 trials indicated that the puerarin injection was better than control drugs at the clinical effective rate (RR 1.22, 95% CI 1.17 to 1.28, P < 0.001) and 16 studies showed the neurological deficit was significantly improved (MD –3.69, 95% CI –4.67 to –2.71, P < 0.001); the hemorheology index and fibrinogen were much lower with the puerarin injection when compared with western conventional medicines (WCM) or other control drugs (the whole blood viscosity: MD –0.89, 95% CI –1.37 to –0.41, P < 0.001; the HCT: MD –0.04, 95% CI –0.06 to –0.02, P < 0.001; the fibrinogen: MD –0.64, 95% CI –0.96 to –0.31, P < 0.001). Eleven trials reported that the adverse reactions related to the puerarin injection included facial flushing, dizziness, vomiting, nausea, and other mild gastrointestinal discomfort and allergic reaction. No serious adverse drug reactions were reported.Conclusions:Puerarin injection may be more effective and relatively safe in clinic for treating acute ischemic stroke. However, the current evidence is insufficient due to the poor methodological quality and lack of adequate safety data. Further RCTs are required to examine its efficacy.

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Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Abstract: Cover titleIncreased blood viscosity in patients with small artery occlusion Key wordsblood viscosity, ischemic stroke, small artery occlusion, pathogenesis, rheology, dehydration 2 Abstract Background and Purpose: High blood viscosity causes blood stagnation and subsequent

Cited by 62 publications

References 30 publications

Middle Cerebral Artery Pulsatility Is Highly Associated with Systemic Blood Viscosity in Acute Ischemic Stroke within 24 Hours of Symptom Onset

Middle Cerebral Artery Pulsatility Is Highly Associated with Systemic Blood Viscosity in Acute Ischemic Stroke within 24 Hours of Symptom Onset

A comparison of erythrocyte sedimentation rates of bloods anticoagulated with trisodium citrate and EDTA among TB presumptive patients at the University of Gondar comprehensive specialized hospital, northwest Ethiopia

Efficacy and safety of puerarin injection in curing acute ischemic stroke

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