Blood serotonin in psychotic and brain damaged children

Campbell, Magda; Friedman, Eitan; DeVito, Estelle; Greenspan, Leon; Collins, Patrick J.

doi:10.1007/bf02104998

Cited by 57 publications

(15 citation statements)

References 9 publications

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“…In accord with our earlier findings (Campbell et al, 1974), low intellectual functioning was associated with statistically significant (t= 2.16, df= 21, p< 0.05, 2-tail test) higher serotonin levels, as shown in table II (IQ, verbal IQ or language DQ very superior to borderline, blood serotonin levels ranging from 0.040 to 0.356 Mg/ml, mean = 0.139 Mg/ml; below borderline to profoundly re tarded, 0.098 to 0.840 Mg/ml, mean = 0.324 Mg/ml). Specifically, of nine chil dren within the higher serotonin group, only one had a borderline IQ (patient No.…”

Section: Resultssupporting

confidence: 83%

“…Various parameters were analyzed. In agreement with our earlier findings (Campbell et al, 1974), no significant relationship between age and serotonin levels in either the patient group (Pearson r= 0.078, NS) or control group (r = 0.275, NS) was found. This is also in accord with the findings of others in mentally retarded children (Partington et al, 1973;Tu and Parting ton, 1972), and is at variance with the findings in normal subjects, where there is a decrease of serotonin (or 5-hydroxyindole) levels with increasing age (Ritvo et al, 1971;Tu and Partington, 1972).…”

Section: Resultssupporting

confidence: 82%

“…In a pilot study we measured blood serotonin levels in young schizophrenics and controls, matched for age, sex, and verbal IQ (Campbell et al, 1974). Blood serotonin levels tended to be higher in patients than in controls (who were all brain damaged), although statistical significance was not attained in this small sample of children.…”

Section: Introductionmentioning

confidence: 99%

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Blood Serotonin in Schizophrenie Children

Campbell¹,

Friedman²,

Wh³

et al. 1975

Int Pharmacopsychiatry

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Blood serotonin levels were measured in schizophrenic children, all of whom showed manifestations of illness in the first 2 years of life, and controls. Serotonin levels were higher in patients (mean = 0.267 μg/ml) than in controls (mean = 0.218 μg/ml), although the difference did not reach statistical significance. Serotonin levels were significantly higher in patients with florid psychosis and those with lower IQs than in patients in remission or partial remission or higher IQs.

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Section: Resultssupporting

confidence: 83%

Section: Resultssupporting

confidence: 82%

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Blood Serotonin in Schizophrenie Children

Campbell¹,

Friedman²,

Wh³

et al. 1975

Int Pharmacopsychiatry

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“…Investigation have been made from various as pects mainly concerning serotonin metabolism. The blood serotonin level in autistic children has been deter mined by a number of investigators including Schain and Freedman [1961], Hanley et al [1977], Yuwiler et al [1975], Campbell et al [1974Campbell et al [ , 1975, Ritvo et al [1970], Ritvo [ 1977], Boullin et al [ 1970Boullin et al [ , 1971 and Suemitsu et al [1974], All these investigators reported that the blood serotonin level was or tended to be higher in autistic chil dren than in a control group. Our present study likewise showed significantly higher blood serotonin levels in au tistic children than in normal children.…”

Section: Discussionmentioning

confidence: 99%

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

et al. 1984

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In 37 autistic children and 67 normal control subjects, determinations of plasma free and total tryptophan and blood serotonin levels were made simultaneously in order to establish a relationship between these parameters and the clinical rating scales: Children’s Psychiatric Rating Scale (CPRS-1), Werry-Weiss-Peters Activity Scale (WWPAS), and Developmental Quotient (DQ). The plasma free tryptophan level was significantly higher in autistic children than in normal control subjects. There tended to be a significant positive correlation between the plasma free tryptophan level and CPRS-1 or WWPAS score and a negative correlation between the plasma free tryptophan level and DQ. The blood serotonin level was significantly higher in autistic children than in normal control subjects. No correlation was established, however, between the blood serotonin level and CPRS-1, WWPAS score or DQ, and hence the clinical symptoms. Nor was there a correlation between blood serotonin and free tryptophan levels in these children. These results suggest that autistic children have some defect in tryptophan-serotonin metabolism in the brain, which is responsible for the clinical manifestations and behavioral abnormalities of infantile autism.

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“…Anomalies of amine metabolism have been implicated in some behavioral disorders of childhood. Alterations in serotonin metabolism and blood levels were found in certain retarded, schizophrenic and autistic children (Boullin et al, 1970;Coleman, 1973; P age, 1968\Partington et al, 1973Ritvo et al, 1970;Schain and Freedman, 1961;Campbell et al, 1974Campbell et al, , 1975. Others have found abnormalities in catecholamine metabolism in autistic and atypical children (Cohen et al, 1975).…”

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confidence: 99%

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

Campbell¹,

Friedman²,

Green³

et al. 1976

Neuropsychobiology

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In this study monoamine oxidase (MAO) activity was measured in blood platelets of 21 individuals (age 2⁶/₁₂^–19 years) who were diagnosed at preschool age as schizophrenics; MAO activity was not significantly different from that found in normals. An insignificant correlation was found between MAO activity in patients and age; a similar correlation for normals was also insignificant. In a sample of 15 families, no significant correlation between MAO activity of patients and their parents was obtained.

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Blood serotonin in psychotic and brain damaged children

Cited by 57 publications

References 9 publications

Blood Serotonin in Schizophrenie Children

Blood Serotonin in Schizophrenie Children

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

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