Blood Serotonin in Schizophrenie Children

Campbell, Magda; Friedman, Erwin; Wh, Green; Pj, Collins; Am, Small; Breuer, Harry

doi:10.1159/000468197

Cited by 53 publications

(9 citation statements)

References 16 publications

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“…Investigation have been made from various as pects mainly concerning serotonin metabolism. The blood serotonin level in autistic children has been deter mined by a number of investigators including Schain and Freedman [1961], Hanley et al [1977], Yuwiler et al [1975], Campbell et al [1974Campbell et al [ , 1975, Ritvo et al [1970], Ritvo [ 1977], Boullin et al [ 1970Boullin et al [ , 1971 and Suemitsu et al [1974], All these investigators reported that the blood serotonin level was or tended to be higher in autistic chil dren than in a control group. Our present study likewise showed significantly higher blood serotonin levels in au tistic children than in normal children.…”

Section: Discussionmentioning

confidence: 99%

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

et al. 1984

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In 37 autistic children and 67 normal control subjects, determinations of plasma free and total tryptophan and blood serotonin levels were made simultaneously in order to establish a relationship between these parameters and the clinical rating scales: Children’s Psychiatric Rating Scale (CPRS-1), Werry-Weiss-Peters Activity Scale (WWPAS), and Developmental Quotient (DQ). The plasma free tryptophan level was significantly higher in autistic children than in normal control subjects. There tended to be a significant positive correlation between the plasma free tryptophan level and CPRS-1 or WWPAS score and a negative correlation between the plasma free tryptophan level and DQ. The blood serotonin level was significantly higher in autistic children than in normal control subjects. No correlation was established, however, between the blood serotonin level and CPRS-1, WWPAS score or DQ, and hence the clinical symptoms. Nor was there a correlation between blood serotonin and free tryptophan levels in these children. These results suggest that autistic children have some defect in tryptophan-serotonin metabolism in the brain, which is responsible for the clinical manifestations and behavioral abnormalities of infantile autism.

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Section: Discussionmentioning

confidence: 99%

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

et al. 1984

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“…They found that there was an inverse relationship between age and serotonin or platelet values in the normal population, that whole blood serotonin concentrations and platelet counts were significantly higher in a group of autistic children than among age-matched controls, and that, in general, serotonin values per platelet did not differ between age-matched groups of autistics and controls, the exception being that very young autistic children had a higher variability of serotonin per platelet values than the corresponding controls. Campbell, Friedman, DeVito, Greenspan, and Collins (1974) and Campbell et al (1975) demonstrated that autistic children tended to have higher platelet-rich plasma serotonin levels than children matched for age, sex, and verbal IQ scores, and that severely retarded autistic children had higher serotonin levels than those who were moderately or mildly retarded. Additionally, psychotic autistic children had higher serotonin concentrations.…”

Section: Introductionmentioning

confidence: 99%

Association of serotonin concentration to behavior and IQ in autistic children

Kuperman

Beeghly

Burns

et al. 1987

J Autism Dev Disord

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Twenty-five boys meeting DSM-III criteria for infantile autism were evaluated for IQ, age, and behavior score on the Autism Behavior Checklist (ABC), in order to determine the ability to predic platelet-rich plasma (PRP) serotonin concentrations. Multiple regression techniques were used to adjust the PRP serotonin concentration for medication and whole blood platelet count to allow meaningful comparisons of serotonin concentrations among the autistic children. Though we found no significant correlation between the adjusted serotonin concentration and the IQ, or between the adjusted serotonin concentration and the various ABC scale scores, four individual items of the ABC did correlate with the adjusted serotonin concentration. Individuals with all of these items appear to be more severely affected with the disorder of autism and have a tendency to higher adjusted PRP serotonin concentration.

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“…Anomalies of amine metabolism have been implicated in some behavioral disorders of childhood. Alterations in serotonin metabolism and blood levels were found in certain retarded, schizophrenic and autistic children (Boullin et al, 1970;Coleman, 1973; P age, 1968\Partington et al, 1973Ritvo et al, 1970;Schain and Freedman, 1961;Campbell et al, 1974Campbell et al, , 1975. Others have found abnormalities in catecholamine metabolism in autistic and atypical children (Cohen et al, 1975).…”

mentioning

confidence: 99%

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

Campbell¹,

Friedman²,

Green³

et al. 1976

Neuropsychobiology

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In this study monoamine oxidase (MAO) activity was measured in blood platelets of 21 individuals (age 2⁶/₁₂^–19 years) who were diagnosed at preschool age as schizophrenics; MAO activity was not significantly different from that found in normals. An insignificant correlation was found between MAO activity in patients and age; a similar correlation for normals was also insignificant. In a sample of 15 families, no significant correlation between MAO activity of patients and their parents was obtained.

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Blood Serotonin in Schizophrenie Children

Cited by 53 publications

References 16 publications

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

Blood Serotonin and Free Tryptophan Concentration in Autistic Children

Association of serotonin concentration to behavior and IQ in autistic children

Blood Platelet Monoamine Oxidase Activity in Schizophrenic Children and Their Families

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