Blood Pressure, Serum Glucose, Cholesterol, and Triglycerides in Dogs with Different Body Scores

Cardoso, Mauro José Lahm; Fagnani, Rafael; Cavalcante, Carolina; Zanutto, Marcelo de Souza; Júnior, Ademir Zacarias; Fertonani, Luciane Holsback da Silveira; Calesso, Jéssica Ragazzi; Melussi, Maíra; Costa, Helena Pinheiro; Hashizume, Eduardo Yudi

doi:10.1155/2016/8675283

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…In the current study, there was no difference in glucose concentrations between the dogs in the overweight and lean categories. Several canine studies have identified changes in glucose concentration associated with overweight status, weight gain and weight loss (39)(40)(41)59), but no such association is evident in other studies (14,(19)(20)(21)24,35,37,60,61). In the present study, fructosamine concentration was did not differ between the dogs in the overweight and lean categories.…”

Section: Associations Between Tg Concentration and Markers Of Ormdcontrasting

confidence: 73%

Body condition score and triglyceride concentrations and their associations with other markers of energy homeostasis in healthy, non-obese dogs

Gomez-Fernandez-Blanco¹,

Peeters²,

Farnir³

et al. 2022

Preprint

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Serum triglyceride concentrations increase in dogs in overweight condition, which is typically assessed by body condition score (BCS). However, their associations with other markers of energy homeostasis are poorly characterized. The present study aimed to evaluate the associations between both BCS and triglyceride levels and other markers of lipid and glucose metabolism in healthy dogs in overweight condition. 534 overweight, but otherwise healthy, client-owned dogs were included. Serum concentrations of cholesterol, free fatty acids, triglycerides, insulin, glucose and fructosamine were measured. Dogs were assigned to lean (BCS: 3-5) or overweight (BCS: 6-7) categories, and linear models were used to assess the differences between BCS categories and the associations between triglycerides and the other variables, correcting for the effect of breed. Globally, "overweight" dogs had greater serum cholesterol (95% CI: 5.3-6.2 mmol/L or 205-237 mg/dL versus 5.1-5.4 mmol/L or 198-210 mg/dl, P = .003), insulin (95% CI: 17.5-22.1 μU/ml versus 16.7-18.0 μU/ml, P = .036) and were older (95% CI: 4.0-5.3 versus 3.4-3.7 years, P = .002) than lean dogs. Triglyceride concentrations were positively associated with fructosamine (r2 = 0.31, P = .001), cholesterol (r2 = 0.25, P < .001), insulin (r2 = 0.14, P = .003) and glucose (r2 = 0.10, P = .002), and negatively associated with free fatty acids (r2 = 0.11, P < .001). There was no association between triglyceride levels and age. In conclusion, both BCS and triglyceride concentrations were associated with other markers of glucose and lipid metabolism in overweight, but otherwise healthy dogs. Triglyceride concentrations were associated with an increase in insulin and fructosamine that might reflect an early-phase impairment in glucose tolerance which, surprisingly, was concurrent with lower basal free fatty acids.

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Section: Associations Between Tg Concentration and Markers Of Ormdcontrasting

confidence: 73%

Body condition score and triglyceride concentrations and their associations with other markers of energy homeostasis in healthy, non-obese dogs

Gomez-Fernandez-Blanco¹,

Peeters²,

Farnir³

et al. 2022

Preprint

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“…These results confirm that plasma leptin levels may be a useful marker for evaluating adiposity regardless of variations in breed, age, or sex [ 29 ]. One study suggested that serum cholesterol, triglyceride, and glucose levels in dogs can be affected by the BCS increasing [ 31 ]. Based on previous studies suggesting that BCS is significantly associated with the circulating levels of leptin, cholesterol, triglycerides, and glucose [ 29 – 31 ], in order to rule out the influence of BCS on the measurement of these analytes, all examined dogs were selected based on similar BCS values (5-6/9).…”

Section: Discussionmentioning

confidence: 99%

Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs

2017

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Leptin and its receptor play several physiological roles in the canine gallbladder, and the dysregulation of leptin might play a role in the pathogenesis of gallbladder diseases such as gallbladder mucocele. Previous studies revealed a positive association between hyperlipidemia and gallstones in humans. However, the latter is still unclear in dogs with cholelithiasis. In this study, we examined the differences in leptin, leptin receptor, total cholesterol, and triglyceride levels between healthy dogs and dogs with cholelithiasis, and evaluated the correlation between leptin and hyperlipidemia. Twenty-eight healthy dogs and 34 client-owned dogs with cholelithiasis were enrolled in the study. Leptin concentrations and lipid profiles were determined from sera, and leptin and leptin receptor expression levels were quantified in gallbladder tissue. In dogs with cholelithiasis, serum concentrations of leptin (p < 0.001), total cholesterol (p < 0.001), and triglycerides (p < 0.001) were significantly higher compared with those in healthy dogs. Positive correlations were observed between serum leptin and total cholesterol (95% confidence interval (CI) = 0.61–0.89, r = 0.725, p < 0.001), and between leptin and triglycerides (95% CI = 0.63–0.89, r = 0.782, p < 0.001) in the cholelithiasis group. Hypercholesterolemia (Odds Ratio (OR) = 9.720; 95% CI = 1.148–82.318) and hypertriglyceridemia (OR = 12.913; 95% CI = 1.548–107.722) were shown to be risk factors for gallstone disease. In cholelithiasis patients who underwent cholecystectomy, serum leptin levels were significantly higher than in patients that had not undergone surgery (p < 0.001). Leptin and leptin receptor expression was upregulated in the gallbladder tissues of cholelithiasis patients (p < 0.01 and p < 0.001, respectively). These results indicate that increased serum leptin concentrations and hyperlipidemia (hypercholesterolemia or hypertriglyceridemia) are associated with canine cholelithiasis and that homeostatic imbalance of these parameters might affect the pathogenesis of gallstones.

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“…Blood tests clearly indicated an increase in the TG levels of obese dogs. Although no significant difference was found in the T‐chol levels, some studies have shown that T‐chol in obese dogs (José Lahm Cardoso et al., 2016 ; Piantedosi et al., 2016 ; Tropf et al., 2017 ) could be used to evaluate the effects of obesity on hyperlipidemia. Therefore, hyperlipidemia can be regarded as a clinical symptom associated with obesity in dogs, as in humans.…”

Section: Discussionmentioning

confidence: 99%

Gene expression of adipokines and inflammatory cytokines in peripheral blood mononuclear cells of obese dogs

Hwang

Kim

et al. 2022

Veterinary Medicine & Sci

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Background: Peripheral blood mononuclear cells (PBMCs) have been identified as a possible marker of inflammation in obesity. Understanding the expression of pro-and anti-inflammatory cytokines in PBMCs in obese dogs will help control obesity-related inflammatory diseases. Objectives:The aim of this study was to evaluate the role of PBMCs in obesityassociated chronic inflammation by analyzing the expression of adipokines and inflammatory cytokines.Methods: Blood samples were obtained from 25 subjects and real-time quantitative polymerase chain reaction determinations were performed to quantify the gene expression levels of adipokines and inflammatory cytokines, including TNF-α, IL-17, leptin, MCP-1, and adiponectin, in the PBMCs. Results:The results showed that the gene expression levels of TNF-α (p < 0.001), IL-17 (p < 0.0001), and leptin (p < 0.0001) were strongly upregulated in the PBMCs of obese dogs compared to that in non-obese dogs. Conclusions:The changes in gene expression levels of inflammation-related adipokines and pro-inflammatory cytokines occur in PBMCs, which may contribute to the low-grade chronic inflammation that is present in obesity.

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Blood Pressure, Serum Glucose, Cholesterol, and Triglycerides in Dogs with Different Body Scores

Cited by 13 publications

References 31 publications

Body condition score and triglyceride concentrations and their associations with other markers of energy homeostasis in healthy, non-obese dogs

Body condition score and triglyceride concentrations and their associations with other markers of energy homeostasis in healthy, non-obese dogs

Associations between serum leptin levels, hyperlipidemia, and cholelithiasis in dogs

Gene expression of adipokines and inflammatory cytokines in peripheral blood mononuclear cells of obese dogs

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