Blood lipids during pregnancy: A progressively appreciated subject in basic and clinical research

Busso, Dolores; Rigotti, Attilio

doi:10.1016/j.atherosclerosis.2018.06.884

Cited by 9 publications

(8 citation statements)

References 27 publications

(20 reference statements)

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“…Similar, evidences were reported in the studies conducted in China, Bangladesh and Nigeria [21,36,46]. LDL-c transports cholesterol to the peripheral tissue and plays significant role in the development of atherosclerosis and cardiovascular disease [47]. The oxidized LDL products modify the lysine residues of Apo-lipoprotein B (apo B) which is recognized by the receptors of macrophages.…”

Section: Plos Onesupporting

confidence: 66%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

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Section: Plos Onesupporting

confidence: 66%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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“…The contents of LDL-cholesterol deposited in the intima of the blood vessel which leads to oxidation of LDL-cholesterol. This oxidation affects the architecture of lipoproteins; this in turn activates macrophage to release in ammatory cytokine and later developed into fatty strakes and atherosclerosis 59,60 . Liver cells synthesized VLDL-cholesterol to transport lipids reach in triacylglycerol into the vascular system 55 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of maternal serum lipid profiles and clinical chemistry parameters in the prediction of pre-eclampsia in pregnant women attending ANC and delivery services

Tesfa

Munshea

Nibret

et al. 2023

Preprint

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Pre-eclampsia (PE) is a pregnancy related metabolic syndrome which adversely influence the mother and their newborn infants. Besides, lack of study in our population, some studies also reporting discrepancies in the association of lipid profiles and clinical chemistry parameters with the risk of PE. Hence, this study was designed to evaluate the diagnostic potential of serum lipid profiles and clinical chemistry parameters with PE. Institution-based case-control study was performed at Bahir Dar city governmental hospitals. The study participants were selected through simple random sampling and the socio-demographic data were collected by interview-administered questionnaire. Five ml of venous blood were collected to evaluate lipid profile and clinical chemistry parameters. Descriptive statistics, chi-squared test, multivariable logistic regression and Mann-Whitney U test were utilized for analysis of variables. ROC and combined ROC curve analysis were executed to check the diagnostic accuracy at 95% CI. A total of 336 study participants (168 cases and 168 controls) were included. The median concentrations of serum triglyceride (229 (180-293.75) vs 194 (158.5–255)), total cholesterol (196 (167.25–224) vs 185.5 (158.5-212.75)), ALT (23(20–32) vs 21 (20–25)) and AST (35 (23.25-45) vs 24 (20–35)) values were significantly increased in cases as compared with normal controls. However, the median concentrations of serum total protein (6.7(6.1–7.4) vs 7.1 (6.7–7.6)) and serum calcium (7.6 (7.1–7.9) vs 7.9(7.5–8.3)) were significantly decreased in cases than controls. Positive correlations were observed between blood pressure and serum levels of triglyceride, total cholesterol, ALT & AST values while negative correlations were shown between blood pressure and HDL-cholesterol, total protein and serum calcium values. The combined ROC curve analysis of serum lipid profiles and clinical chemistry parameters showed a moderate prediction potential of PE. Hence, serum lipid profiles and clinical chemistry parameters were utilized as the diagnostic biomarkers of PE. However, to generate tangible evidence on the roles of lipid profiles and clinical chemistry parameters in PE pathogenesis and to include them as routine diagnostic biomarker multi-center prospective studies will be warranted.

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“…Preeclampsia is suggested to result from dysregulation of hepatic lipase and lipoprotein lipase leading to dyslipidaemia. The excessive accretion of lipids within endothelial cells alters the level of prostacyclin which could lead to endothelial dysfunction and oxidative stress, factors implicated as initiators of preeclampsia [31,32]. The altered levels of insulin, lipids and, other factors implicated in the development of the metabolic syndrome have been observed to persist in women who had preeclampsia suggesting a causal relationship between both entities [33].…”

Section: Discussionmentioning

confidence: 99%

Maternal Lipid Profile in Preeclampsia: Case-Control Study

Agbara

Rabiu

Gbadegesin

et al. 2021

JAMMR

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Background: Preeclampsia has continued to be a challenge especially in the areas of understanding the pathogenesis and prevention or treatment of the disease. Previous reports on the relationship between maternal lipids and preeclampsia have varied as its role in the aetiopathogenesis of pre-eclampsia is not clearly defined. This study aimed at comparing the lipid profile in preeclampsia with that in normotensive pregnancy. It also examined for any relationship between an abnormal profile and severe disease. Methods: This was a prospective case-control study. It was conducted among pregnant women who presented for routine antenatal care and those seen in the emergency room of the obstetrics unit of a tertiary institution in Lagos, Nigeria. The duration of the study was 6 months as it took place between May 2015 to October 2015. Pregnant women in their second half of pregnancy, diagnosed to have pre-eclampsia and, who gave consent were consecutively recruited as cases and pregnant women with similar age and gestational age, who had normal blood pressure were also selected as controls within the study period. The Maternal lipid profile was assayed using an enzyme-based assay kit and analysed according to the manufacturer’s instructions. All participants were followed up till delivery. Results: One hundred and seventy pregnant women in the third trimester of pregnancy participated in this study. They were within 18 – 45 years of age. More of the participants were nulliparous. Eighty-five of them had pre-eclampsia and constituted the study group while 85 were normotensive in the control group. The mean age was similar in both groups (control=29.59 ± 4.50 years versus pre-eclampsia=29.73 ± 5.10 years). The gestational ages at blood sampling of the patients in this study ranged between 27 – 40 weeks. The analysis of data revealed that the level of total cholesterol, triglycerides, low-density lipoprotein and very-low-density lipoprotein was higher in the cases compared with the control. This difference was statistically significant because the calculated P-value was <0.05. The level of high-density lipoprotein was lower in those with pre-eclampsia. Serum cholesterol and low-density lipoprotein were significantly higher (P-value= 0.04) in those with severe disease. A significant positive relationship was observed between mean arterial blood pressure and abnormal levels of lipids. Conclusion: An abnormal pattern of lipid profile was observed in women with preeclampsia and this was more marked in those with severe disease. A larger multi-centre study will be required to substantiate this finding.

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Blood lipids during pregnancy: A progressively appreciated subject in basic and clinical research

Cited by 9 publications

References 27 publications

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Evaluation of maternal serum lipid profiles and clinical chemistry parameters in the prediction of pre-eclampsia in pregnant women attending ANC and delivery services

Maternal Lipid Profile in Preeclampsia: Case-Control Study

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