Blood levels of brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS): A systematic review and meta-analysis

Karimi, Nastaran; Ashourizadeh, Helia; Pasha, Boshra Akbarzadeh; Haghshomar, Maryam; Jouzdani, Tahmineh; Shobeiri, Parnian; Teixeira, Antônio Lúcio; Rezaei, Nima

doi:10.1016/j.msard.2022.103984

Cited by 24 publications

(18 citation statements)

References 89 publications

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“…Studies on the changes in serum BDNF levels in MS are conflicting, showing both higher and lower levels in comparison with healthy controls [ 24 , 83 ]. Some authors suggest that the method of measurement as well as disease duration might account for this variability [ 84 ]. Interestingly, recent studies have shown that in patients with relapsing–remitting MS, the BDNF concentration is elevated in the relapse phase [ 83 ].…”

Section: Bdnf In Immune-related Diseasesmentioning

confidence: 99%

The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review

Sochal

Ditmer

Gabryelska

et al. 2022

JCM

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Brain-derived neurotrophic factor (BDNF) is a neurotrophin regulating synaptic plasticity, neuronal excitability, and nociception. It seems to be one of the key molecules in interactions between the central nervous system and immune-related diseases, i.e., diseases with an inflammatory background of unknown etiology, such as inflammatory bowel diseases or rheumatoid arthritis. Studies show that BDNF levels might change in the tissues and serum of patients during the course of these conditions, e.g., affecting cell survival and modulating pain severity and signaling pathways involving different neurotransmitters. Immune-related conditions often feature psychiatric comorbidities, such as sleep disorders (e.g., insomnia) and symptoms of depression/anxiety; BDNF may be related as well to them as it seems to exert an influence on sleep structure; studies also show that patients with psychiatric disorders have decreased BDNF levels, which increase after treatment. BDNF also has a vital role in nociception, particularly in chronic pain, hyperalgesia, and allodynia, participating in the formation of central hypersensitization. In this review, we summarize the current knowledge on BDNF’s function in immune-related diseases, sleep, and pain. We also discuss how BDNF is affected by treatment and what consequences these changes might have beyond the nervous system.

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Section: Bdnf In Immune-related Diseasesmentioning

confidence: 99%

The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review

Sochal

Ditmer

Gabryelska

et al. 2022

JCM

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“…[99][100][101][102][103] A previous meta-analysis similarly showed that BDNF had favorable advantages in treating PD and reducing PD with depression. [104][105][106][107][108][109][110] To determine whether age and ethnicity are connected to the outcomes of our study, well-conducted randomized controlled trials are needed.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson’s disease patients

Chen¹,

Zhang²

2022

Adv Clin Exp Med

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“…Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration [ 37 ]. Recent meta-analysis showed that blood levels of BDNF are decreased in PD and MS patients [ 38 , 39 ]. Another primary functional alteration that could directly affect plasticity is reduced synaptic number, which could make it more difficult to attain sufficient number of cooperatively active synapses, which is necessary for network modification.…”

Section: Exercise Enhances Brain Plasticitymentioning

confidence: 99%

Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Lü

Wang

et al. 2023

Transl Neurodegener

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Physical exercise is of great significance for maintaining human health. Exercise can provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently, with the aging of the world’s population and increase of life expectancy, cognitive dysfunction has gradually become a disease of high incidence, which is accompanied by neurodegenerative diseases in elderly individuals. Patients often exhibit memory loss, aphasia and weakening of orientation once diagnosed, and are unable to have a normal life. Cognitive dysfunction largely affects the physical and mental health, reduces the quality of life, and causes a great economic burden to the society. At present, most of the interventions are aimed to maintain the current cognitive level and delay deterioration of cognition. In contrast, exercise as a nonpharmacological therapy has great advantages in its nontoxicity, low cost and universal application. The molecular mechanisms underlying the effect of exercise on cognition are complex, and studies have been extensively centered on neural plasticity, the direct target of exercise in the brain. In addition, mitochondrial stability and energy metabolism are essential for brain status. Meanwhile, the organ-brain axis responds to exercise and induces release of cytokines related to cognition. In this review, we summarize the latest evidence on the molecular mechanisms underlying the effects of exercise on cognition, and point out directions for future research.

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Blood levels of brain-derived neurotrophic factor (BDNF) in people with multiple sclerosis (MS): A systematic review and meta-analysis

Cited by 24 publications

References 89 publications

The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review

The Role of Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review

A meta-analysis on the role of brain-derived neurotrophic factor in Parkinson’s disease patients

Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

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