Blood Eosinophils and Eosinophil Cationic Protein after Acute Myocardial Infarction or Corticosteroid Administration

Hällgren, Roger; Venge, Per; Cullhed, I; Olsson, Inge

doi:10.1111/j.1365-2141.1979.tb03707.x

Cited by 36 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ECP enhances factor XII-dependent reactions, shortens the coagulation time of normal plasma, inactivate the anticoagulant activity of heparin, and inhibits the anticoagulant activity of glycosylated form of thrombomodulin [ 6 , 14 , 22 ]. Secondly, circulating eosinophils decreased under various environment such as acute inflammation and AMI [ 17 , 23 ]. Our study showed that circulating eosinophils was decreased in patients with AIS.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The significance of eosinophils in predicting the severity of acute ischemic stroke

Wang

Lin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

BackgroundPrevious studies have shown that tumor-associated tissue eosinophilia have a role in various types of solid tumors. However, the relationship between eosinophil and acute ischemic stroke (AIS) is unclear. We aimed to investigate the diagnostic significance of eosinophil in AIS patients.MethodsThis study included 300 AIS patients without hypereosinophilic syndrome (HES). The hematologic indices were collected from each patient, including white blood count, eosinophil count, eosinophil percentage, neutrophil count, red blood count, and platelet. The severity of AIS was estimated by national institute of health stroke scale (NIHSS). Logistic regression analyses were performed to confirm the biomarkers for NIHSS and in-hospital non-death among the cases. Moreover, receiver-operating characteristics (ROC) analyses were used to investigate the clinical performances of eosinophils and NIHSS in prediction of non-death.ResultsThe admission NIHSS (P<0.001) and BMI (P<0.001) were predictors to the non-death of the patients. There was a significant correlation between eosinophil counts or eosinophil percentage and NIHSS score (r= -0.451, P < 0.001; r= -0.617, P<0.001, Spearson Correlation). ROC analysis showed that eosinophil counts and eosinophil percentage could predict non-death of the patients in-hospital, with the areas under the curves (AUC) of 0.791 and 0.867, respectively.ConclusionsOur study revealed a relationship between eosinophil and NIHSS score in the patients with AIS. Eosinophils might have certain value for predicting the severity of AIS.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Alternatively ECP may be released from circulating eosinophils as a response to mediators which are activated in the inflammatory reaction. In the latter case eosinophils can not be recognized in the circulation [ 23 ]. Thirdly, EPOX accumulate at sites of eosinophil inflammation.…”

Section: Discussionmentioning

confidence: 99%

The significance of eosinophils in predicting the severity of acute ischemic stroke

Wang

Lin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…These activated mast cells can then release histamine, which can result in arterial spasm. Hallgren et al (10) suggested the active participation of eosinophils in the inflammatory process in patients with acute myocardial infarction, and Trillo et al (11) found eosinophils in the aortic fatty streaks of African green monkeys. Moreover, the enzyme arachidonate 15-lipoxygenase is expressed in significant quantities in eosinophils (12).…”

Section: Discussionmentioning

confidence: 99%

Eosinophil Count Is Positively Correlated with Albumin Excretion Rate in Men with Type 2 Diabetes

Fukui¹,

Tanaka²,

Hamaguchi³

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Background and objectives: Patients with allergic disorders such as allergic rhinitis or asthma have been reported to be at increased risk for atherosclerosis. In this study, we evaluated the relationships between peripheral eosinophil count and degree of albumin excretion rate, which is a useful marker of cardiovascular mortality as well as diabetic nephropathy in patients with type 2 diabetes.Design, setting, participants, & measurements: We evaluated relationships of peripheral eosinophil count to degree of albumin excretion rate as well as to major cardiovascular risk factors, including age, BP, serum lipid concentration, and glycemic control (glycosylated hemoglobin); body mass index; current treatment for diabetes; smoking status; and presence of cardiovascular disease in 783 patients (416 men and 367 women) with type 2 diabetes.Results: Log(eosinophil count) was positively associated with systolic BP (r ‫؍‬ 0.124, P ‫؍‬ 0.0108), serum triglyceride concentration (r ‫؍‬ 0.108, P ‫؍‬ 0.0284), and log(albumin excretion rate) (r ‫؍‬ 0.301, P < 0.0001) in men; however, no association was found between log(eosinophil count) and log(albumin excretion rate) (r ‫؍‬ 0.085, P ‫؍‬ 0.1050) in women. Multivariate linear regression analysis demonstrated that log(eosinophil count) (␤ ‫؍‬ 0.260, P < 0.0001), duration of diabetes (␤ ‫؍‬ 0.203, P ‫؍‬ 0.0003), glycosylated hemoglobin (␤ ‫؍‬ 0.117, P ‫؍‬ 0.0238), systolic BP (␤ ‫؍‬ 0.205, P ‫؍‬ 0.0001), and serum triglyceride concentration (␤ ‫؍‬ 0.162, P ‫؍‬ 0.0038) were independent determinants of log(albumin excretion rate) in men.Conclusions: Allergic disorders may be associated with microalbuminuria in men with type 2 diabetes.

show abstract

“…Such small percentage degranulation should not be detectable as a decreased intracellular content. However, available data suggest that this calculation is based on approximately a tenfold underestimation of the turnover of lactoferrin [20] and ECP [21], Then it should have been possible to demon strate a degranulation of circulating cells.…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis-Induced Increase in Serum Lactoferrin and Serum Eosinophil Cationic Protein as Signs of Local Neutrophil and Eosinophil Degranulation

Hällgren

Venge

Wíkström

1981

Nephron

Self Cite

View full text Add to dashboard Cite

Transient reductions in circulating polymorphonuclear granulocytes and eosinophils were observed early in hemodialysis. About a threefold increase in serum-lactoferrin occurred 2 h from the start of hemodialysis. Increments of the serum levels of eosinophil cationic protein (ECP) were observed as early as 1 h after initiation of hemodialysis, reaching maximum levels (about a fourfold increase from initial levels) 1 h later. When fresh blood was circulated through a dialyzer without having a patient in the circuit considerable increases of lactoferrin and ECP were also found. The intracellular contents of lactoferrin and ECP in granulocytes isolated from peripheral blood were unaffected throughout the dialysis period. Sera obtained at different times during dialysis induced no release of granular proteins from isolated granulocytes in vitro. The raised serum concentrations of lactoferrin and ECP during dialysis suggest that a local degranulation of neutrophils and eosinophils may take place probably in the dialyzer.

show abstract

Blood Eosinophils and Eosinophil Cationic Protein after Acute Myocardial Infarction or Corticosteroid Administration

Cited by 36 publications

References 15 publications

The significance of eosinophils in predicting the severity of acute ischemic stroke

The significance of eosinophils in predicting the severity of acute ischemic stroke

Eosinophil Count Is Positively Correlated with Albumin Excretion Rate in Men with Type 2 Diabetes

Hemodialysis-Induced Increase in Serum Lactoferrin and Serum Eosinophil Cationic Protein as Signs of Local Neutrophil and Eosinophil Degranulation

Contact Info

Product

Resources

About