The significance of eosinophils in predicting the severity of acute ischemic stroke

Abstract

BackgroundPrevious studies have shown that tumor-associated tissue eosinophilia have a role in various types of solid tumors. However, the relationship between eosinophil and acute ischemic stroke (AIS) is unclear. We aimed to investigate the diagnostic significance of eosinophil in AIS patients.MethodsThis study included 300 AIS patients without hypereosinophilic syndrome (HES). The hematologic indices were collected from each patient, including white blood count, eosinophil count, eosinophil percentage, neutrophil count, red blood count, and platelet. The severity of AIS was estimated by national institute of health stroke scale (NIHSS). Logistic regression analyses were performed to confirm the biomarkers for NIHSS and in-hospital non-death among the cases. Moreover, receiver-operating characteristics (ROC) analyses were used to investigate the clinical performances of eosinophils and NIHSS in prediction of non-death.ResultsThe admission NIHSS (P<0.001) and BMI (P<0.001) were predictors to the non-death of the patients. There was a significant correlation between eosinophil counts or eosinophil percentage and NIHSS score (r= -0.451, P < 0.001; r= -0.617, P<0.001, Spearson Correlation). ROC analysis showed that eosinophil counts and eosinophil percentage could predict non-death of the patients in-hospital, with the areas under the curves (AUC) of 0.791 and 0.867, respectively.ConclusionsOur study revealed a relationship between eosinophil and NIHSS score in the patients with AIS. Eosinophils might have certain value for predicting the severity of AIS.

Analysis of early stroke-induced changes in circulating leukocyte counts using transcriptomic deconvolution

“…With respect to dendritic cells, our observations are consistent with those reported in the limited number of prior cytometric studies performed in humans [24]. With respect to eosinophils, this current study is one of the first case-control analyses to report evidence of an acute reduction in eosinophil counts in response to stroke; our observations align well with two recent associative studies reporting that post-stroke circulating eosinophil counts are negatively correlated with stroke severity and risk of mortality [25,26], suggesting that the pathophysiological relevance of a stroke-induced reduction in peripheral blood eosinophil counts warrants further investigation.…”

Absolute blood eosinophil count could be a potential biomarker for predicting haemorrhagic transformation after intravenous thrombolysis for acute ischaemic stroke

“…Contrary to previously published results by Wang et al [17], we did not find any significant correlation between AEC and baseline NIHSS. This discrepancy of results may be due to the fact that in the study by Wang et al [17] all patients presenting with AIS were included independent of the time from symptom onset, whereas we obtained AEC within 4.5 h after the onset of AIS symptoms; it is unknown whether AEC is a dynamic variable as is the case with NLR [18], therefore, results may vary due to possible rapid change of its values after the onset of symptoms.…”

“…Few studies have previously looked at the role of eosinophils in AIS: eosinopenia (defined by authors as the percentage of eosinophils < 0.3%) at admission has been reported to be a significant risk factor for mortality at 2 months after AIS [15] and other authors have shown that patients with higher AEC are more likely to have AIS without functional involvement of the limbs compared to patients with lower AEC [16]. Contrary to previously published results by Wang et al [17], we did not find any significant correlation between AEC and baseline NIHSS. This discrepancy of results may be due to the fact that in the study by Wang et al [17] all patients presenting with AIS were included independent of the time from symptom onset, whereas we obtained AEC within 4.5 h after the onset of AIS symptoms; it is unknown whether AEC is a dynamic variable as is the case with NLR [18], therefore, results may vary due to possible rapid change of its values after the onset of symptoms.…”

Dynamic Change of Eosinophil and Acute Ischemic Stroke

“…Eosinopenia also be the result of degranulation which made eosinophils no longer be recognized in the circulation 29 . Eosinophil granule proteins, including eosinophil cationic protein, eosinophil peroxidase, and major basic protein can cause cytotoxic protein-mediated thrombosis and endothelial injury 30 . ECP also stimulates broblast migration and brosis, which could be play an important role in the development of atherosclerosis [31][32][33][34] .…”