Dynamic Change of Eosinophil and Acute Ischemic Stroke

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:bold>Background:</jats:bold> Eosinopenia has been shown to be a predicative factor for the infection and mortality in ischemic stroke patients which mainly focused on static eosinophil count. This study aimed to explore the relationship between dynamic change of eosinophil count and short-term prognosis of acute ischemic stroke (AIS).<jats:bold>Methods:</jats:bold> A total of 174 patients with AIS were respectively enrolled. Blood samples for blood routine examination were obtained at admission before any treatments and the next day. Eosinopenia was defined as the continuous decrease of the count of eosinophil from the first day to the second. Infarct volume was measured by diffusion-weighted MR imaging volume. 90-day modified Rankin Scale scores were collected to assess the prognosis of patients with AIS.<jats:bold>Results: </jats:bold>Patients were divided into two groups according to whether they have eosinopenia. Patients with eosinopenia were more likely to have large infarct volume (3.2 [0.6-39.9] cm<jats:sup>3 </jats:sup>vs 1.1 [0.3-6.0] cm<jats:sup>3</jats:sup>, <jats:italic>P </jats:italic>=.004). Receiver operating characteristic analysis demonstrated that the eosinophil count on the second day was more accurate than the time of admission to identify the large cerebral infarction (LCI) (0.866 vs 0.603, <jats:italic>P </jats:italic>＜.001). Logistic regression analysis revealed that eosinopenia was independently associated with LCI (<jats:italic>P </jats:italic>=.015) and poor outcome (<jats:italic>P </jats:italic>=.011), and patients with eosinopenia had a 4.05-fold greater risk for LCL (95% CI 1.31-12.51) and a 4.29-fold greater risk for worse clinical outcomes (95% CI 1.27-14.51) than patients without.<jats:bold>Conclusion： </jats:bold>Eosinophil is a dynamic variable, and its variation is associated with poor outcome in acute ischemic stroke patients.</jats:p>

Arterial and venous thromboembolism risk associated with blood eosinophils: A systematic review and meta‐analysis

“…Ultimately, 22 articles were included with 805 329 subjects. Of these 22 articles, 13 were cohort studies, 3–9,12,13,20–23 6 were cross‐sectional studies, 10,14,24–27 and 3 were case–control studies 11,28,29 . Of the included studies, 14 studies were related to cardiovascular diseases, 3 were related to cerebral thrombosis/cerebral infarction, and 6 were related to venous thrombotic events, among which the study by Anoop et al involved both cardiovascular disease and cerebral artery thrombosis 9 …”

“…Only the study by Hori et al described the long-term effect of EOS count on ischemic stroke 9 ; there was no strong association between a low EOS count and ischemic stroke in the general population, either in the first 6 months or over a median follow-up of 3.8 years (RR: 1.17, 95% CI: 0.87-1.56; RR: 1.02, 95% CI: 0.88-1.19, both p > 0.05, respectively). For the secondary outcome, in 2 studies evaluating mortality, 6,22 an increased EOS count led to an increased risk for poor short-term prognosis, with an RR of 2.87 without heterogeneity in the short-term follow-up (95% CI: 1.49-5.51, p = 0.002, I 2 = 0) (Figure 3A).…”

“…Coronary artery thrombosis and cerebral artery thrombosis, also called acute myocardial infarction (AMI) and ischemic stroke, respectively, are the most common arterial thrombotic diseases affecting patient health. [4][5][6][7][8][9][10][11] Recently, there has been increased clinical interest in the use of EOS counts as a predictor of coronary and cerebral arterial thrombosis disorders. However, the findings concerning EOS count and coronary or cerebral thrombosis disorders vary widely across studies.…”