Blood donor screening: how to decrease the risk of transfusion-transmitted hepatitis B virus?

Niederhauser, Christoph; Taleghani, Behrouz Mansouri; Graziani, Mauro; Stolz, Martin; Tinguely, Caroline; Schneider, Philippe

doi:10.4414/smw.2008.12001

Cited by 21 publications

(5 citation statements)

References 42 publications

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“…The study showed high levels 10100> IU/ml in donors Iraqi (47.2%) . Our findings agree with Niederauser et al (23), and Bahatti et al (21). The investigators stressed that blood components positive for anti-HBc with anti-HBs do not appear to transmit HBV and there is clearly an inverse correlation between anti-HBs level and infectivity(3).…”

Section: Serological Patterns Of Hepstitis B Virus Among Hbsag Negati...supporting

confidence: 91%

“…For comparison, studies performed in Iran, prevalence of anti-HBc alone in patients with past infection was 3.9% (21), in Lebanese decreased to 2.2% blood donors were anti-HBc alone (22). Refers Niederbauser et al to low rate anti-HBC to 2% by Nucleic acid testing(NAT) (23). Similarly, anti-HBc alone was reported in 2.1% of Saudi blood donors (24).…”

Section: Serological Patterns Of Hepstitis B Virus Among Hbsag Negati...mentioning

confidence: 99%

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Serological Patterns of Hepstitis B Virus Among HBsAg Negative Blood Donors in Baghdad, Iraq by Using Architect System

et al. 2016

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Background: About 10-15% of population HBV infection becomes chronic, and 85-90% are resolved. In Iraq, HBs-Ag assay by ELISA is only mandatory test for detection of HBV infection in blood donors. Anti- HBc and anti-HBs were not detectable in their sera.Objective: To investigate the distribution of serological patterns for HBV who were HBsAg negative.Material and method: Between July 18, 2011 to December 25, 2011, 10ml of blood samples were collected from National blood Transfusion Center donors, Baghdad, for 25782 individuals (25294 male, 488 female), mean age (20-65)years. HbsAg positive sera excluded (185), and final number of donors included in thestudy was 25597 HbsAg negative.Result: The data showed a previous exposure for HBV(p>0.05) through anti-HBc and anti-HBs 3.8% by Architect system. The anti-HBs combine with anti-HBc was 68.5%, while anti-HBc alone was 31.5%. Independent risk factors were association with married, history of blood transfusion and residence.Conclusion: The prevalence of the HBV in Iraq is 4.6% as intermediate region at first time.

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Section: Serological Patterns Of Hepstitis B Virus Among Hbsag Negati...supporting

confidence: 91%

Section: Serological Patterns Of Hepstitis B Virus Among Hbsag Negati...mentioning

confidence: 99%

Serological Patterns of Hepstitis B Virus Among HBsAg Negative Blood Donors in Baghdad, Iraq by Using Architect System

et al. 2016

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“…For Switzerland, the incidence of acute HBV was <0.4/100,000 population [ 15 ]. Niederhauser et al [ 10 ] reported variable prevalence data of anti-HBc between 1.2 and 1.7% assessing more than 22,000 Swiss blood donors. However, recent data showed increasing numbers of chronically HBV-infected individuals in Switzerland, linked to immigration activity [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Switzerland, screening of blood donors comprises HBsAg and individual donation HBV NAT (HBV-ID-NAT) to select HBV-negative blood donors. Since Switzerland is considered a low prevalence country for hepatitis B [ 10 ], the residual risk of HBV transmission by blood products was considered negligible, and anti-HBc testing of blood donors was deemed not cost-efficient. However, improvements in HBV NAT techniques, i.e., mini-pool testing replaced by individual donation testing ameliorated sensitivity of 3rd generation HBV NAT revealing donors with trace HBV viremia, which were missed by previous screening protocols.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Occult Hepatitis B Virus Infection in Blood Donors with Negative ID-NAT in Switzerland

Zbinden

Ries

Redli

et al. 2022

Transfus Med Hemother

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Introduction: Screening of hepatitis B surface antigen (HBsAg) and individual-donation nucleic acid amplification testing (ID-NAT) of blood donors have become standard to detect hepatitis B virus (HBV) infection. However, there is still a residual risk of HBV transmission by blood components of donors suffering from occult HBV infection (OBI). Therefore, many countries implemented universal testing of anti-HBV core antigen (anti-HBc) antibodies in order to increase blood safety. In Switzerland, anti-HBc testing is not part of the routine blood donor-screening repertoire. Therefore, we sought to assess prevalence of donors with OBI in a Swiss blood donor collective. Methods: Blood donations were prospectively investigated for the presence of anti-HBc antibodies during two time periods (I: all donors, March 2017; II: first-time donors only, April 2017 until February 2018). Anti-HBc-positive findings were confirmed by an anti-HBc neutralization test. Discarded plasma samples of anti-HBc-confirmed positive donors were ultracentrifuged and subsequently retested by regular HBV-ID-NAT to search for traces of HBV. Results: During time period I, 78 (1.6%) individuals out of 4,923 donors were confirmed anti-HBc-positive. Sixty-nine (88%) anti-HBc-positive samples were available and processed by ultracentrifugation followed by repeat HBV-ID-NAT. Four samples (5.8%) were found positive for HBV DNA. Sixty-five (94.2%) samples remained HBV NAT-negative upon ultracentrifugation. During time period II, 56 (0.9%) donor samples out of 6,509 exhibited anti-HBc-confirmed positive. Fifty-five (98%) samples could be reassessed by HBV-ID-NAT upon ultracentrifugation. Three (5.5%) samples contained HBV DNA and 52 (94.5%) samples remained HBV NAT-negative. Conclusion: Overall, we detected 7 viremic OBI carriers among 11,432 blood donors, which tested negative for HBV by standard HBV-ID-NAT and HBsAg screening. In contrast, OBI carriers showed positive anti-HBc findings which could be confirmed in 83.8% of the cases. Thus, OBI might be missed by the current HBV screening process of Swiss blood donors. We suggest to review current HBV screening algorithm. Extended donor screening by anti-HBc testing may unmask OBI carriers and contribute to blood safety for the recipient of blood products.

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“…Although implementing HBsAg testing in routine screening of blood donors in the early 1970s has dramatically improved transfusion safety, HBV transmission remains the most frequent transfusion-transmitted viral infection. 10 , 11 , 12 OBI can be considered a potential risk factor for individuals with thalassemia, hemophilia, and in the context of hemodialysis. 13 Additionally, OBI is of significance in bone marrow and organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

Rate of occult hepatitis B virus infection among individuals with tuberculosis in northeastern Iran: A molecular epidemiological study

Ghezeldasht

Soleimanpour

Hedayati-Moghaddam

et al. 2023

Journal of Virus Eradication

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Blood donor screening: how to decrease the risk of transfusion-transmitted hepatitis B virus?

Cited by 21 publications

References 42 publications

Serological Patterns of Hepstitis B Virus Among HBsAg Negative Blood Donors in Baghdad, Iraq by Using Architect System

Serological Patterns of Hepstitis B Virus Among HBsAg Negative Blood Donors in Baghdad, Iraq by Using Architect System

Prevalence of Occult Hepatitis B Virus Infection in Blood Donors with Negative ID-NAT in Switzerland

Rate of occult hepatitis B virus infection among individuals with tuberculosis in northeastern Iran: A molecular epidemiological study

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