Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India

Rath, Soumini; Panda, Santosh Kumar; Nayak, M. M.; Pradhan, Deepti Damayanty

doi:10.18203/2349-3291.ijcp20190686

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Gram-negative organisms were detected in the majority of cases (59.80%), which is consistent with the findings of prior research [27][28][29].…”

Section: Resultssupporting

confidence: 91%

Bacteriological Profile of Clinically Suspected Septicemia Among Neonates and the Antibiotic Susceptibility Pattern of Their Isolates: A Cross-Sectional Study in a Tertiary Care Hospital of Jharkhand

VIMAL,

SINGH,

SUMANGALA BISWAS

et al. 2024

Asian J Pharm Clin Res

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Objectives: Neonatal septicemia is a generalized bacterial infection that occurs during the first 4 weeks of life and is one of the four primary causes of neonatal mortality and morbidity in India. This study aims to determine the bacteriological profile and antibiotic sensitivity patterns of isolates from blood cultures of suspected septicemic neonates in a tertiary care hospital. Methods: Two hundred and twenty-eight blood samples were collected and processed from patients in accordance with standard protocol. The antibiotic susceptibility of the isolates was determined by the disk diffusion method according to Clinical and Laboratory Standards Institute recommendations. Results: Blood culture results were positive in 44.7% of the patients. Late-onset sepsis was present in 53.92%, and early-onset sepsis was observed in 46.08% of the cases. The best overall sensitivity among Gram-negative isolates was to Amikacin, followed by Gentamycin and Meropenem. Gram-positive isolates had sensitivity to Chloramphenicol, tetracycline, Linezolid, Tetracycline, Vancomycin, and Piperacillin. Conclusion: The most common causes of newborn sepsis in this study were Gram-negative organisms (Klebsiella pneumoniae, Escherichia coli, and Citrobacter freundii) and Gram-positive organisms (Staphylococcus aureus), the majority of which are antibiotic-resistant.

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“…Gram-negative organisms were detected in the majority of cases (59.80%), which is consistent with the findings of prior research [27][28][29].…”

Section: Resultssupporting

confidence: 91%

Bacteriological Profile of Clinically Suspected Septicemia Among Neonates and the Antibiotic Susceptibility Pattern of Their Isolates: A Cross-Sectional Study in a Tertiary Care Hospital of Jharkhand

VIMAL,

SINGH,

SUMANGALA BISWAS

et al. 2024

Asian J Pharm Clin Res

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“…In our study, Klebsiella pneumoniae was found to be the most frequently isolated microorganism (95%) followed by Candida albicans (18.32%). Among Gram positive isolates, Coagulase Negative Staphylococci (CoNS) were found to the predominant pathogen these findings are similar with Rath et al, (14) and Rashwan et al, (15).…”

Section: Discussionsupporting

confidence: 86%

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

et al. 2021

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Introduction and Aim: Neonatal infections are the leading cause of mortality among neonates after prematurity. The importance determining biological markers to be used as a diagnostic test to detect neonatal infections the in early stage of the disease is a challenge. The purpose of this study was to evaluate the usefulness & sensitivity of various serological markers such as serum Procalcitonin, C-reactive protein and chemokine IL-6 for diagnosis of neonatal infections leading to sepsis in new born infants. Materials and Methods: This cross-sectional study was carried out among newborns admitted in neonatal intensive care unit (NICU) and meeting the selection criteria. Samples were collected for blood culture and ELISA was performed for detection of CRP, PCT & IL-6. Results: A total of 300 newborns were included in this study from NICU of which 132 (44%) neonates was found to be blood culture positive. The most frequently isolated organisms were Klebsiella pneumoniae (26.5%), followed by Candida albicans (18.1%). In case of confirmed neonatal sepsis, significant higher levels of CRP, PCT and IL-6 were detected than in cases of probable sepsis. Serum procalcitonin levels exhibit highest sensitivity and specificity as 65.91% and 91.67% respectively. Conclusion: Serum procalcitonin has better diagnostic utility in terms of biological marker for the diagnosis of neonatal infections than C- reactive protein and Interleukin-6.

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“…The MDR strains were found in 35% of cases which is lower than MDR strains found in other studies [ 5 , 21 ]. The prevalence of ESBL producing bacteria in our study was 40% which is lower than other studies in India [ 29 - 30 ].…”

Section: Discussioncontrasting

confidence: 63%

Bacteriological Profile and Outcome of Culture-Positive Neonatal Sepsis in a Special Newborn Care Unit Setting, Odisha

Mohakud¹,

Mishra²,

Nayak³

et al. 2022

Cureus

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Introduction: Nearly one-third of neonatal mortality in India is due to neonatal sepsis and death occurs in 30% of culture-positive neonates. Pathogens such as Klebsiella pneumoniae and Escherichia coli are the most common bacteria responsible for neonatal sepsis in India and South Asia. Materials and Methods: It was an observational study, conducted in special newborn care units (SNCUs) of Capital Hospital in Bhubaneswar, Odisha from May 2017 to October 2019. All neonates (<28 days of life) with blood culture-positive sepsis were included in this study. Blood cultures were sent in all the babies with features of clinical sepsis. The demographic profile of neonates, clinical presentations, isolated organisms, and their sensitive patterns was recorded for analysis. Results: Blood culture was sent in 445 suspected neonates with clinical sepsis out of which 115 blood culture positive organisms were isolated. Among the isolated organisms, 42 (35.6%) cases were Staphylococcus aureus followed by Coagulase negative Staphylococcus (CONS) (20.8%), E. coli (19.1%), K. pneumoniae (10.4%), Acinetobacter baumannii (2.7%), Enterobacter spp.(4.3%), Enterococcus spp. (4.3%), and Pseudomonas aeruginosa (2.7%). S. aureus was the predominant organism found in both early and late-onset sepsis. All Gram-negative bacilli (GNB) are resistant to ampicillin whereas cephalosporin resistance was found in 68% of cases. Mortality due to sepsis was 8%. Conclusion: S. aureus followed by CONS was found to be the most common cause of sepsis in SNCU. A high degree of resistance of organisms to penicillins and cephalosporins calls for a re-evaluation of antibiotic policy and protocols for empirical treatment in neonatal sepsis.

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Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India

Cited by 5 publications

References 8 publications

Bacteriological Profile of Clinically Suspected Septicemia Among Neonates and the Antibiotic Susceptibility Pattern of Their Isolates: A Cross-Sectional Study in a Tertiary Care Hospital of Jharkhand

Bacteriological Profile of Clinically Suspected Septicemia Among Neonates and the Antibiotic Susceptibility Pattern of Their Isolates: A Cross-Sectional Study in a Tertiary Care Hospital of Jharkhand

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

Bacteriological Profile and Outcome of Culture-Positive Neonatal Sepsis in a Special Newborn Care Unit Setting, Odisha

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