Blood coagulation and fibrinolysis after extreme short-term exercise

Hilberg, Thomas; Prasa, Dagmar; Stürzebecher, Jörg; Gläser, Doreen; Schneider, Kathrin; Gabriel, Holger

doi:10.1016/s0049-3848(03)00283-4

Cited by 32 publications

(32 citation statements)

References 29 publications

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“…Blood samples collected from individuals that exercised intensely showed increased numbers of all cell types including segmented and stab (band) neutrophils, lymphocytes, monocytes, and eosinophils. This increase could be due to potentiating the sheer blood flow that occurs during this sort of exercise as previously described [17] . It could also be due to the release of catecholamine which was reported to be increased in plasma after intensive short-term exercise [8,11] .…”

Section: Sand Kl Et Al Exercise Affects Leukocytosis and Hemostasismentioning

confidence: 58%

“…In 15 healthy individuals who performed strenuous exercise for 15, 45 and 90 s, it was observed that this exercise did not induce blood coagulation, whereas fibrinolysis, e.g., generation of tissue-plasminogen activator "t-PA" was increased after 15 s and remained high through the duration of exercise. The release of t-PA might be due to increased catecholamine concentrations and blood sheerstress, whereas no increase in D-dimer generation was observed [17] . In contrast, Gunga et al [18] observed that PT and APTT were both increased in 15 healthy individuals after 30 s exercise, and that t-PA and D-dimer levels were also elevated after the same period suggesting that shorttime intensive exercise shifts the homeostasis system into a higher equilibrium.…”

Section: Introductionmentioning

confidence: 92%

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Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Sand

Flatebø

Andersen

et al. 2013

WJEM

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AIM:To investigate the effects of exercise on healthy individuals of both genders. METHODS:This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further sub-divided into two groups; in the first group individuals run (or skied in the winter time) and then rested for 3 h, whereas individuals in the second group intensely cycled for 5 min. The status of health was determined by measuring the sedimentation rate and the intensity of exercises by measuring the heart rate. Blood samples were collected before and after exercise. RESULTS:We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation. However, all cell types were increased in the circulation after 5 min intense exercise. No differences in the pattern of cell increase were observed among the genders. Activated partial thromboplastin time (APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood. APTT is reduced and D-dimer values significantly increased after intense exercise. However, APTT was statistically lower in males than females, whereas no differences in the D-dimer values were observed among the genders. CONCLUSION:Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders. A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.

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Section: Sand Kl Et Al Exercise Affects Leukocytosis and Hemostasismentioning

confidence: 58%

Section: Introductionmentioning

confidence: 92%

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Sand

Flatebø

Andersen

et al. 2013

WJEM

View full text Add to dashboard Cite

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“…It is well known that vascular alterations and other diseases, as well as lipid levels, body mass index, the fitness level itself, and the type of exercise, its length and intensity, all influence coagulation and fibrinolysis. 16,[23][24][25][26] Many of these confounders could be eliminated by the study design used.…”

Section: Discussionmentioning

confidence: 99%

Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged Participants

Menzel

Hilberg

2008

Clin Appl Thromb Hemost

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Increased age is associated with a higher risk of thrombotic events. The aim of this study was to investigate the age-related changes in hemostasis before and after moderate exercise controlled by individual anaerobic threshold as recommended for rehabilitation training. In this study, 24 young (25 + 1 years) and 24 middle-aged healthy nonsmokers (48 + 1 years) underwent an individualized exercise test with 80% of individual anaerobic threshold (young individuals: 127 + 6 W; middle-aged individuals: 128 + 5 W; values are expressed as mean + standard error of mean) for 60 minutes. The blood samples were collected before and after the exercise. The age-related higher (P .05) levels could be detected in factors II, VII, VIII, IX, XI, XII, prothrombin fragment 1þ2, in tissue plasminogen activator antigen and activity, as well as in plasminogen. The relative exercise-induced increases in these parameters were similar in both groups, although beginning at a higher level for those in the middle-aged group. A statistically enhanced increase after exercise in the middle-aged group could be shown in prothrombin fragment 1þ2 (young individuals: 98 + 6 to 102 + 6 pmol/L; middle-aged individuals: 138 + 7 to 156 + 8 pmol/L) and in thrombin-antithrombin complex (young individuals: 2.2 + 0.1 to 3.1 + 0.2 mg/L; middle-aged individuals: 2.4 + 0.3 to 3.9 + 0.6 mg/L); the latter only showing a tendency. The data show the age-related changes with a rise in blood coagulation and fibrinolysis in a healthy middle-aged group compared with younger participants. Moderate exercise leads to comparably relative increases in hemostatic parameters but starting at higher levels. However, the exercise-induced thrombin generation (prothrombin fragment 1þ2) is enhanced in the middle-aged participants in comparison with younger participants, but may be compensated by a sufficient fibrinolysis, and therefore the hemostatic system remains in balance.

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“…However, the further increase in tPA activity or antigen was observed in the exercises combined with KAATSU. It has been reported that the fibrinolytic responses to exercise are related to changes in plasma lactate and /or NOR (Davis et al, 1976;Wheeler et al, 1986;Weltman et al, 1994;Hilberg et al, 2003b). The underlying mechanism has not been clarified, but it may depend on exercise intensity and duration exercise.…”

Section: Discussionmentioning

confidence: 99%

Effects of KAATSU training on haemostasis in healthy subjects

Nakajima

Takano

Kurano

et al. 2007

Int. J. KAATSU Ttaining Res.

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Purposes: The KAATSU training is performed under the reduction of muscle blood flow by a speciallydesigned belt (KAATSU belt), which induces blood pooling in capacitance vessels by restricting venous return. However, no prior studies have examined the effects of KAATSU training on haemostasis. The purpose of the present study was to investigate acute effects of KAATSU training on haemostasis including fibrinolytic responses in healthy subjects. Methods: Two protocols have been performed. (1) 6 healthy men (mean age= 48 ± 5 yr) performed KAATSU (160 mmHg) of both thighs for 15 minutes and then KAASTU training combined with low-intensity leg and foot aerobic exercises for ~10 minutes in hypobaric chamber, which mimics 8000 feet in airflight. (2) Another 7 men (mean age=30 ± 4 yr) performed leg press exercises (30 % 1 RM) with and without KAATSU of both thighs 24 h after bed rest. Blood samples were taken at rest, immediately after KAATSU, and exercises with or without KAATSU, and after exercise. For the investigation of blood fibrinolysis, determinations of tissue-type plasminogen activator (tPA) activity or antigen, plasminogen activator inhibitor (PAI)-1 activity or antigen, fibrin degradation product (FDP) and D-dimer were used. Prothrombin time (PT) and platelet counts were also measured. Results: (1) In hypobaric chamber, KAATSU by itself significantly increased tPA activity, while PAI-1 activity was unchanged. Furthermore, immediately after the exercise, tPA activity increased significantly. (2) During the exercises combined with KAATSU 24 h after bed rest, tPA antigen significantly increased, compared with control exercises, but PAI-1 antigen was unchanged. In both cases, KAATSU training did not induce fibrin formation as assessed by fibrin D-dimer and FDP. Conclusions: This study indicates that potentially favorable changes occur in fibrinolytic factors after KAATSU and KAATSU training in healthy subjects.

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Blood coagulation and fibrinolysis after extreme short-term exercise

Cited by 32 publications

References 29 publications

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged Participants

Effects of KAATSU training on haemostasis in healthy subjects

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