Blood cells separation in a T-shaped microchannel fabricated by a micromilling technique

Madureira, Miguel; Faustino, Vera; Schütte, Helmut; Gaßmann, Stefan; Lima, Rui

doi:10.24243/jmeb/2.5.171

Cited by 3 publications

(6 citation statements)

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“…Furthermore, Madureira et al ( 2018 ) extended the work of Tripathi et al ( 2013 ) for higher channel dimension for the separation of RBCs (Ovine RBCs and dextran 40) for a 5% Hct. As previously reported (Jaggi et al 2007 ; Yang et al 2005 , 2006 ), the microfluidic devices, i.e., straight T-channel (Fig.…”

Section: Microchannel-based Geometries Exploited In Plasma Separation...mentioning

confidence: 94%

“…Sedimentation and centrifugation are one of the conventional passive separation techniques of the RBCs and Plasma (Haeberle et al 2006 ; Madureira et al 2018 ; Prabhakar et al 2015 ; Tripathi et al 2016 ). In case of sedimentation process, the gravitational force causes the separation and eventually different layers of blood constituents can be achieved in a test tube in which whole blood would be filled, for instance, RBCs at bottom of the tube while the carbohydrates, mineral salt, protein and hormone rich plasma layer would collect at the top layer.…”

Section: Plasma Separation Techniquesmentioning

confidence: 99%

“…2 (Jaggi et al 2007 ; Tripathi et al 2013 ; Tripathi et al 2015a , b ; Yang et al 2005 , 2006 ; Huang et al 2010 ). It has also been noted that the centrifugation technique also been used by only one researcher for T-channel (Madureira et al 2018 ). Similarly, the passive separation technique has been the choice of the researchers while exploiting the Y-channel (see Fig.…”

Section: Plasma Separation Techniquesmentioning

confidence: 99%

“…T-channels found to be a popular device among many researchers for separating plasma from human whole/diluted blood at both the micro- and macro- levels (Madureira et al 2018 ; Jaggi et al 2007 ; Tripathi et al 2013 ; Tripathi et al 2015a , b ; Yang et al 2005 , 2006 ; Huang et al 2010 ; Fenton et al 1985 ). A rigorous review on the T-channel leads to the tabulation of details related to channel dimensions ( D* ), separation techniques (ST), targeted/separated component (SC), flow rate ( Q 0 ), separation efficiency (SE) and purity; presented in Table 1 along with important remarks.…”

Section: Microchannel-based Geometries Exploited In Plasma Separation...mentioning

confidence: 99%

“…10 Comparison of the various channel-based microfluidic devices geometries in terms of the separation efficiencies for the whole blood (Hct ≥ 37%). [1]: Catarino et al ( 2019 ); [2]: Kim et al ( 2021 ); [3]: Songjaroen et al ( 2012 ); [4]: Guo et al ( 2020 ); [5]: Luo et al ( 2018 ); [6]: Sollier et al ( 2010 ); [7]: Dalili et al ( 2013 ); [8]: Goldsmith et al ( 1989 ); [9]: Barbee and Cokelet ( 1971 ); [10]: Madureira et al ( 2018 ); [11]: Kaun et al ( 2018 ); [12]: Berendsen et al ( 2019 ); [13]: Kersaudy-Kerhoas et al ( 2010b ) …”

Section: Comparative Analysis Of Various Channel-based Microfluidicmentioning

confidence: 99%

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Microfluidics geometries involved in effective blood plasma separation

Maurya

Murallidharan

Sharma

et al. 2022

Microfluid Nanofluid

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The last two decades witnessed a significant advancement in the field of diluted and whole blood plasma separation. This is one of the common procedures used to diagnose, cure and treat numerous acute and chronic diseases. For this separation purpose, various types of geometries of microfluidic devices, such as T-channel, Y-channel, trifurcation, constriction–expansion, curved/bend/spiral channels, a combination of any of the two geometries, etc., are being exploited, and this is detailed in this review article. The evaluation of the performance of such devices is based on the several parameters such as separation efficiency, flow rate, hematocrits, channel dimensions, etc. Thus, the current extensive review article endeavours to understand how particular geometry influences the separation efficiency for a given hematocrit. Additionally, a comparative analysis of various geometries is presented to demonstrate the less explored geometric configuration for the diluted and whole blood plasma separation. Also, a meta-analysis has been performed to highlight which geometry serves best to give a consistent separation efficiency. This article also presents tabulated data for various geometries with necessary details required from a designer’s perspective such as channel dimensions, targeted component, studied range of hematocrit and flow rate, separation efficiency, etc. The maximum separation efficiency that can be achieved for a given hematocrits and geometry has also been plotted. The current review highlights the critical findings relevant to this field, state of the art understanding and the future challenges.

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