Blood arsenic: Pan-India prevalence

Iyer, Sandhya; Sengupta, Caesar; Velumani, Amruta

doi:10.1016/j.cca.2016.02.001

Cited by 10 publications

(5 citation statements)

References 6 publications

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Section: Introductionmentioning

confidence: 99%

“…Routes of exposure to As in humans include ingestion, inhalation, and absorption through the skin [ 6 ]. Exposure to As can also occur through drinking water or eating foods that are contaminated by As-containing pesticides or soil rich in As [ 6 ]. Exposure to As through inhalation or skin absorption mainly occurs through occupational exposure to As in various industries or agricultural farming [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Rahbar

Samms‐Vaughan

Zhao

et al. 2022

IJERPH

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Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play an important role in the metabolism of xenobiotics including As in humans. Using data from 375 typically developing children (2–8 years) in Jamaica, we investigated the environmental and sociodemographic factors, as well as their possible interactions with the children’s genotype for GST genes in relation to having a detectable level of blood As concentration (i.e., >1.3 μg/L). Using multivariable logistic regression, we have identified environmental factors significantly associated with blood As concentrations that include a child’s age, parental education levels, and the consumption of saltwater fish, cabbage, broad beans, and avocado (all p < 0.01). Based on the multivariable analysis including gene x environment interactions, we found that among children with the Ile/Ile genotype for GSTP1 Ile105Val, children who consumed avocado had higher odds of having a detectable blood As concentration compared to children who did not eat avocado.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Rahbar

Samms‐Vaughan

Zhao

et al. 2022

IJERPH

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“…For the multivariate regression analysis, we compiled a list of potential confounders for the relationship between exposure (i.e., ‘village’) and arsenic concentration in blood using existing literature for effects of borehole water, homegrown vegetables and age on arsenic in blood (Hall et al 2006 ; Iyer et al 2016 ; Rahbar et al 2012 ; Bibi et al 2015 ; Sekhar et al 2003 ). Therefore, the variables included in the regression model were exposed/unexposed village, age, borehole water as main source of water, and consumption of homegrown vegetables (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Relations between personal exposure to elevated concentrations of arsenic in water and soil and blood arsenic levels amongst people living in rural areas in Limpopo, South Africa

Kapwata

Wright

Reddy

et al. 2023

Environ Sci Pollut Res

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Exposure to arsenic even at low levels can lead to adverse health outcomes, however, there is a paucity of research from South Africa in relation to human exposure to arsenic. We investigated long-term exposure of residents in Limpopo province, South Africa, in a cross-sectional study by analysing water, soil and blood arsenic concentrations from two arsenic-exposed (high and medium–low exposure) villages and one non-exposed (control) village. There were statistically significant differences in the distribution of arsenic in water, soil and blood amongst the three sites. The median drinking water arsenic concentration in the high-exposure village was 1.75 µg/L (range = 0.02 to 81.30 µg/L), 0.45 µg/L (range = 0.100 to 6.00 µg/L) in the medium- / low-exposure village and 0.15 µg/L (range = < limit of detection (LOD) to 29.30 µg/L) in the control site. The median soil arsenic concentration in the high-exposure village was 23.91 mg/kg (range = < LOD to 92.10 mg/kg) whilst arsenic concentrations were below the limit of detection in all soil samples collected from the medium-/low-exposure and control villages. In the high-exposure village, the median blood arsenic concentration was 1.6 µg/L (range = 0.7 to 4.2 µg/L); 0.90 µg/L (range = < LOD to 2.5 µg/L) in the medium-/low-exposure village and 0.6 µg/L (range = < LOD to 3.3 µg/L) in the control village. Significant percentages of drinking water, soil and blood samples from the exposed sites were above the internationally recommended guidelines (namely, 10 µg/L, 20 mg/kg and 1 µg/L, respectively). Majority of participants (86%) relied on borehole water for drinking and there was a significant positive correlation between arsenic in blood and borehole water (p-value = 0.031). There was also a statistically significant correlation between arsenic concentrations in participants’ blood and soil samples collected from gardens (p-value = 0.051). Univariate quantile regression found that blood arsenic concentrations increased by 0.034 µg/L (95% CI = 0.02–0.05) for each one unit increase in water arsenic concentrations (p < 0.001). After adjusting for age, water source and homegrown vegetable consumption in multivariate quantile regression, participants from the high-exposure site had significantly higher blood concentrations than those in the control site (coefficient: 1.00; 95% CI = 0.25–1.74; p-value = 0.009) demonstrating that blood arsenic is a good biomarker of arsenic exposure. Our findings also provide new evidence for South Africa on the association between drinking water and arsenic exposure, emphasising the need for the provision of potable water for human consumption in areas with high environmental arsenic concentrations.

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“…Due to poisonous effects of arsenic, awareness among the people has to be raised. It is the only way to tackle arsenic toxicity [33]. Adequate knowledge of drinking water and awareness to use a good source of water can be a useful public health intervention which can prevent many health related problems globally.…”

Section: Objectivementioning

confidence: 99%

Role of Public Awareness Ensuring the Sustainability of Arsenic Mitigation

Singha

Sikdar

2021

JPRI

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Arsenic poisoning is the largest mass poisoning in history. It causes numerous toxic effects to human health which ultimately leads to cancer or Alzheimer’s disease. Nearly 300 million people over 180 countries worldwide are suffering from the arsenic contaminated groundwater more than WHO directed limit. Despite of its potential fatal toxicities, there is no effective treatment for arsenicosis. Cost-effective arsenic removal technology is also a matter of considerable research. This study aimed to summarize the individual and social issues related to arsenic problem and the remedies suggested by different authors to cope with the adverse effects of arsenic. Reported studies emphasized that only mass awareness and mass education can stop the spreading of this disaster. This study will be helpful for future research on the awareness on arsenic contamination and studies on assessing behavior in different context. Policymakers may find it as helpful resource since it describes the problem from grass-roots level. Researchers’ of pharmaceuticals and medicines may be inspired to perform their research in this field.

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Blood arsenic: Pan-India prevalence

Cited by 10 publications

References 6 publications

Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica

Relations between personal exposure to elevated concentrations of arsenic in water and soil and blood arsenic levels amongst people living in rural areas in Limpopo, South Africa

Role of Public Awareness Ensuring the Sustainability of Arsenic Mitigation

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