1997
DOI: 10.1016/s0920-1211(96)01017-0
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Blockade of spreading depression in chronic epileptic rats: reversion by diazepam

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Cited by 50 publications
(31 citation statements)
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“…As well established, GABA is the main inhibitory neurotransmitter in the brain, being actively involved in cortical organization processes (Zheng and Knudsen 1999;Feldman 2000). The GABAergic neurons and receptors also seem to participate in the CSD modulation, as previous studies indicated (Bures et al 1975;Guedes et al 1992;Guedes and Cavalheiro 1997). Taken together, these data are compatible with the hypothesis of a modulatory action of GABA activity on the cortical CSD-susceptibility.…”
Section: Nutrition and Developing Body And Brain Weightssupporting
confidence: 82%
“…As well established, GABA is the main inhibitory neurotransmitter in the brain, being actively involved in cortical organization processes (Zheng and Knudsen 1999;Feldman 2000). The GABAergic neurons and receptors also seem to participate in the CSD modulation, as previous studies indicated (Bures et al 1975;Guedes et al 1992;Guedes and Cavalheiro 1997). Taken together, these data are compatible with the hypothesis of a modulatory action of GABA activity on the cortical CSD-susceptibility.…”
Section: Nutrition and Developing Body And Brain Weightssupporting
confidence: 82%
“…38 In the neocortex of normal laboratory animals, under certain conditions there may be a direct relationship between excitability and CSD susceptibility. However, when the tissue undergoes exaggerated increased excitability (which is the case of the epileptic brain), it may became more resistant to CSD, as documented by our laboratory, 13,39 as well as by others. 40 Considering the above-mentioned possibility of excitability changes in several brain regions due to L-arginine administration, it can be concluded that the present results represent one of those situations in which Larginine-nitric oxide relationships influence brain electrical activity in the neocortex.…”
Section: Discussionsupporting
confidence: 60%
“…8,9 CSD is considered as a phenomenon related to brain excitability and, as such, has been causally associated with important human diseases like migraine, 10 brain ischemia, 11 and epilepsy. 7,12,13 The developing brain can easily suffer morphological and electrophysiological changes as a consequence of early malnutrition. Depending on its intensity and duration, nutritional deficiency early in life can modify histological 14 and biochemical 15 patterns of developmental processes in the brain, influencing its functions.…”
Section: Introductionmentioning
confidence: 99%
“…41,42 Since CSD is considered a phenomenon related to brain excitability, it has been causally associated with some human diseases, for example, brain ischemia, 43 migraine 44 and epilepsy. 38,45,46 The brain susceptibility to CSD is considered increased when the CSD-velocity of propagation becomes higher as compared to the control situation, and vice-versa. CSD has been characterized in laboratory animals under conditions of pharmacological, nutritional and environmental manipulation.…”
Section: Introductionmentioning
confidence: 99%