2007
DOI: 10.1080/10284150701590316
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Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats

Abstract: As several other factors, nutritional deficiency and sensory input hyperactivation can influence the mammalian brain development. This work investigated the effects of repeated episodes of early peripheral electrostimulation (PE), associated or not with early malnutrition, on cortical spreading depression (CSD) propagation. From postnatal days 7-28, well-nourished and malnourished Wistar rat pups (whose mothers were fed a 23 and 8% protein diet, respectively) received daily sessions of repetitive PE (2 or 60 H… Show more

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Cited by 12 publications
(4 citation statements)
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“…If this hypothesis has merit, then one should predict that sensory manipulations on the opposite direction (i.e., peripheral sensory activation instead of suppression) would lead to CSD propagation changes that would be contrary (i.e., decrease in CSD propagation velocity) to the presently reported increased CSD propagation. In fact, this has actually been observed by Monte‐Silva et al (2007). These authors submitted developing rats to daily sessions of repetitive peripheral electrical stimulation of the left paws delivered by two electrodes attached to them.…”
Section: Discussionsupporting
confidence: 68%
“…If this hypothesis has merit, then one should predict that sensory manipulations on the opposite direction (i.e., peripheral sensory activation instead of suppression) would lead to CSD propagation changes that would be contrary (i.e., decrease in CSD propagation velocity) to the presently reported increased CSD propagation. In fact, this has actually been observed by Monte‐Silva et al (2007). These authors submitted developing rats to daily sessions of repetitive peripheral electrical stimulation of the left paws delivered by two electrodes attached to them.…”
Section: Discussionsupporting
confidence: 68%
“…These conditions include nutritional, metabolic, environmental, hormonal, and pharmacological factors. Some of these conditions facilitate CSD, as for example malnutrition (Rocha‐de‐Melo et al., ), hypoglycemia (Costa‐Cruz et al., ), and γ‐aminobutyric acid (GABA)‐enhancing drugs (Guedes et al., ), while others like serotoninergic drugs (Amâncio‐dos‐Santos et al., ), hypernutrition (Rocha‐de‐Melo et al., ), aging (Guedes et al., ), and peripheral afferent stimulation (Monte‐Silva et al., ) impair CSD.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, first indications that myelin may affect CSD derive from nutritional studies: Malnutrition of young rats was shown to cause dysmyelination within the CNS 39. Interestingly, malnourished rats early in life displayed greater CSD velocities than well‐nourished control animals 40. It was thus speculated that deficient myelination may account for this observation, but other causalities such as altered cell‐packing density, neuron‐to‐glia ratio, or synaptic neurotransmitters were also envisaged.…”
Section: Discussionmentioning
confidence: 99%