Blockade of CD40L inhibits immunogenic maturation of lung dendritic cells: Implications for the role of lung iNKT cells in mouse models of asthma

Deng, Nishan; Chen, Qianhui; Guo, Xuxue; Liu, Linlin; Chen, Shuo; Wang, Ailing; Li, Ruiyun; Huang, Yann-Chang; Ding, Xuhong; Yu, Hong; Hu, Shaoxian; Zhao, Yang; Chen, Xueqin; Nie, Hanxiang

doi:10.1016/j.molimm.2020.03.009

Cited by 6 publications

(3 citation statements)

References 64 publications

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“…α-Galactosylceramide (α-GalCer) is the prototypical antigen of iNKT cells. Along with iNKT cells exhibiting memory cell characteristics, activation induces the rapid release of cytokines, and cytotoxic capabilities [48].…”

Section: Invariant Natural Killer T (Inkt) Cellsmentioning

confidence: 99%

“…In murine models of disease, enhanced activity and/or frequency of iNKT cells has been associated with allergic asthma [48], alcoholic and nonalcoholic liver disease [49,50], and ischemia-reperfusion injury resulting from sickle cell disease [51]. Increased frequency of activated iNKT cells was observed in the circulation of human participants with sickle cell disease [52] and nonalcoholic steatohepatitis [50].…”

Section: Invariant Natural Killer T (Inkt) Cellsmentioning

confidence: 99%

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Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets

Woude¹,

Krebs²,

Filoche³

et al. 2020

Immunometabolism

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Metabolic diseases continue to rise in global prevalence. Although there is evidence that current methods of treatment are effective, the continued rise in prevalence indicates that alternative, more efficient treatment options are needed. Over the last several years, immune cells have been increasingly studied as important players in the development of a range of diseases, including metabolic diseases such as obesity and obesityinduced type 2 diabetes. This review explores how understanding the intrinsic metabolism of innate-like T cells could provide potential targets for treating metabolic disease, and highlights research areas needed to advance this promising therapeutic approach.

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Section: Invariant Natural Killer T (Inkt) Cellsmentioning

confidence: 99%

Section: Invariant Natural Killer T (Inkt) Cellsmentioning

confidence: 99%

Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets

Woude¹,

Krebs²,

Filoche³

et al. 2020

Immunometabolism

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show abstract

“…A previous study reported that CD40 may induce apoptosis of carcinoma cells through a mechanism involving TRAF3 and JNK/AP-1 activation (18). At present, the effect of CD40L on tumors has become a popular topic in the field of tumor pathogenesis (19)(20)(21). Additionally, CD40 activation has anti-apoptotic or apoptotic effects in follicular lymphoma (FL) cell lines (PMID: 28610909) (22).…”

Section: Introductionmentioning

confidence: 99%

Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway

Feng

Wang

2020

Oncol Lett

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The incidence of non-Hodgkin's lymphoma (NHL) has been increasing annually and has become a serious threat to human health. However, the pathogenesis of NHL remains unclear. The present study aimed to investigate the effect of soluble CD40 ligand (sCD40L) on NHL cells and its underlying mechanism. Cell Counting kit-8 assay and flow cytometry apoptosis experiments were conducted to investigate the effects of sCD40L on cell proliferation and apoptosis. Western blotting was performed to detect the protein expression levels of BAX, Bcl-2, ERK, p-ERK, JNK, p-JNK, p38, p-p38 and c-JUN. The results of the present study demonstrated that exogenous sCD40L significantly inhibited the proliferation and promoted the apoptosis of Raji and CA46 cells. Additionally, exogenous sCD40L promoted the apoptosis of lymphoma cells by activating the JNK signaling pathway.

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Anti-F4/80 treatment attenuates Th2 cell responses: Implications for the role of lung interstitial macrophages in the asthmatic mice

Deng

Guo

Chen

et al. 2021

International Immunopharmacology

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Blockade of CD40L inhibits immunogenic maturation of lung dendritic cells: Implications for the role of lung iNKT cells in mouse models of asthma

Cited by 6 publications

References 64 publications

Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets

Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets

Soluble CD40 ligand inhibits the growth of non‑Hodgkin's lymphoma cells through the JNK signaling pathway

Anti-F4/80 treatment attenuates Th2 cell responses: Implications for the role of lung interstitial macrophages in the asthmatic mice

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