Innate-like T Cells in the Context of Metabolic Disease and Novel Therapeutic Targets

Abstract

Metabolic diseases continue to rise in global prevalence. Although there is evidence that current methods of treatment are effective, the continued rise in prevalence indicates that alternative, more efficient treatment options are needed. Over the last several years, immune cells have been increasingly studied as important players in the development of a range of diseases, including metabolic diseases such as obesity and obesityinduced type 2 diabetes. This review explores how understanding the intrinsic metabolism of innate-like T cells could provide potential targets for treating metabolic disease, and highlights research areas needed to advance this promising therapeutic approach.

Childhood Adiposity Associated With Expanded Effector Memory CD8+ and Vδ2+Vγ9+ T Cells

“…Yet, this previous study did observe higher numbers of effector memory Vδ2 + Vγ9 + T cells (22). The exact role of Vδ2 + Vγ9 + T in metabolic diseases remains to be studied (47). Increased differentiation of Vδ2 + Vγ9 + T cells has been associated with decreased IFN-γ responses and thereby a reduced host defense against viral antigens (22,48).…”