Anti-F4/80 treatment attenuates Th2 cell responses: Implications for the role of lung interstitial macrophages in the asthmatic mice

Deng, Nishan; Guo, Xuxue; Chen, Qianhui; Liu, Linlin; Chen, Shuo; Wang, Ailing; Li, Ruiyun; Huang, Yann-Chang; Ding, Xuhong; Yu, Hong; Hu, Shaoxian; Zhao, Yang; Chen, Xueqin; Nie, Hanxiang

doi:10.1016/j.intimp.2021.108009

Cited by 2 publications

(1 citation statement)

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“…This immune imbalance was restored after omalizumab treatment [ 69 ]. Anti-F4/80 treatment of OVA-induced asthmatic mice inhibited alternately activated macrophages and also attenuated Th2 cell response in lung tissue [ 70 ]. Similarly, reducing the levels of IL-4, IL-5, and IL-13 in the lung and the number of Th2 cells in mediastinal lymph nodes, while increasing the number of Treg cells in mediastinal lymph nodes, can alleviate allergic airway inflammation [ 71 ].…”

Section: Cd4 + T Cells In Lung Homeostasismentioning

confidence: 99%

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Guo

2022

Journal of Immunology Research

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Cytokine secretion, such as interleukin-4 (IL-4), IL-5, IL-9, IL-13, and amphiregulin (Areg), by type 2 innate lymphoid cells (ILC2s) is indispensable for homeostasis, remodeling/repairing tissue structure, inflammation, and tumor immunity. Often viewed as the innate cell surrogate of T helper type 2 (Th2) cells, ILC2s not only secrete the same type 2 cytokines, but are also inextricably related to CD4+T cells in terms of cell origin and regulatory factors, bridging between innate and adaptive immunity. ILC2s interact with CD4+T cells to play a leading role in a variety of diseases through secretory factors. Here, we review the latest progress on ILC2s and CD4+T cells in the lung, the close relationship between the two, and their relevance in the lung disease and immunity. This literature review aids future research in pulmonary type 2 immune diseases and guides innovative treatment approaches for these diseases.

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Section: Cd4 + T Cells In Lung Homeostasismentioning

confidence: 99%