Protective effect of β-glucan on Poly(I:C)-induced acute lung injury/inflammation: Therapeutic implications of viral infections in the respiratory system

Tirunavalli, Satya Krishna; Pramatha, Shashidhar; Eedara, Abhisheik Chowdary; Walvekar, Komal Paresh; Immanuel, Christiana; Potdar, Pooja; Nayak, Pawan G.; Chamallamudi, Mallikarjuna Rao; Sistla, Ramakrishna; Chilaka, Sabarinadh; Andugulapati, Sai Balaji

doi:10.1016/j.lfs.2023.122027

Cited by 6 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B-1-3-D-glucans (beta-glucans) represent main components of the microbial cell wall or can be secreted by fungi, such as Saccharomyces cerevisiae or Candida albicans [ 95 ]. Beta-glucans bind a specific receptor, dectin-1, on dendritic cells, monocytes–macrophages and neutrophils, whose binding accounts for activation of the NF-kB pathway with production of pro-inflammatory cytokines [ 96 , 97 , 98 ]. Conversely, in a murine polymicrobial sepsis model, beta-glucan treatment diminished morbidity and mortality, inhibiting NF-kB, while triggering phosphoinositide-3-kinase.…”

Section: Natural and Biological Products As An Alternative Treatment ...mentioning

confidence: 99%

Current Views about the Inflammatory Damage Triggered by Bacterial Superantigens and Experimental Attempts to Neutralize Superantigen-Mediated Toxic Effects with Natural and Biological Products

Santacroce,

Topi,

Charitos

et al. 2024

Pathophysiology

View full text Add to dashboard Cite

Superantigens, i.e., staphylococcal enterotoxins and toxic shock syndrome toxin-1, interact with T cells in a different manner in comparison to conventional antigens. In fact, they activate a larger contingent of T lymphocytes, binding outside the peptide-binding groove of the major histocompatibility complex class II. Involvement of many T cells by superantigens leads to a massive release of pro-inflammatory cytokines, such as interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor-alpha and interferon-gamma. Such a storm of mediators has been shown to account for tissue damage, multiorgan failure and shock. Besides conventional drugs and biotherapeutics, experiments with natural and biological products have been undertaken to attenuate the toxic effects exerted by superantigens. In this review, emphasis will be placed on polyphenols, probiotics, beta-glucans and antimicrobial peptides. In fact, these substances share a common functional denominator, since they skew the immune response toward an anti-inflammatory profile, thus mitigating the cytokine wave evoked by superantigens. However, clinical applications of these products are still scarce, and more trials are needed to validate their usefulness in humans.

show abstract

Section: Natural and Biological Products As An Alternative Treatment ...mentioning

confidence: 99%

Current Views about the Inflammatory Damage Triggered by Bacterial Superantigens and Experimental Attempts to Neutralize Superantigen-Mediated Toxic Effects with Natural and Biological Products

Santacroce,

Topi,

Charitos

et al. 2024

Pathophysiology

View full text Add to dashboard Cite

show abstract

Biotechnological potential of yeast cell wall: An overview

Jofre,

Queiroz,

Sanchez

et al. 2024

Biotechnology Progress

View full text Add to dashboard Cite

The yeast cell wall is a complex structure whose main function is to protect the cell from physical and chemical damage, providing it with rigidity. It is composed of a matrix of covalently linked polysaccharides and proteins, including β‐glucans, mannoproteins, and chitin, whose proportion can vary according to the yeast species and environmental conditions. The main components of the yeast cell wall have relevant properties that expand the possibilities of use in different industrial sectors, such as pharmaceutical, food, medical, veterinary, and cosmetic. Some applications include bioremediation, enzyme immobilization, animal feed, wine production, and hydrogel production. In the literature it is the description of the cell wall composition of model species like Saccharomyces cerevisiae and Candida albicans, however, it is important to know that this composition can vary according to the species or the culture medium conditions. Thus, understanding the structural composition of different species holds promise as an alternative to expanding the utilization of residual yeast from different bioprocesses. In the context of a circular economy, the conversion of residual yeast into valuable products is an attractive prospect for researchers aiming to develop sustainable technologies. This review provides an overview of yeast cell wall composition and its significance in biotechnological applications, considering prospects to increase the diversification of these compounds in industry.

show abstract

Vistusertib improves pulmonary inflammation and fibrosis by modulating inflammatory/oxidative stress mediators via suppressing the mTOR signalling

Shaikh,

Chandra,

Andugulapati

et al. 2024

Inflamm. Res.

View full text Add to dashboard Cite

Protective effect of β-glucan on Poly(I:C)-induced acute lung injury/inflammation: Therapeutic implications of viral infections in the respiratory system

Cited by 6 publications

References 63 publications

Current Views about the Inflammatory Damage Triggered by Bacterial Superantigens and Experimental Attempts to Neutralize Superantigen-Mediated Toxic Effects with Natural and Biological Products

Current Views about the Inflammatory Damage Triggered by Bacterial Superantigens and Experimental Attempts to Neutralize Superantigen-Mediated Toxic Effects with Natural and Biological Products

Biotechnological potential of yeast cell wall: An overview

Vistusertib improves pulmonary inflammation and fibrosis by modulating inflammatory/oxidative stress mediators via suppressing the mTOR signalling

Contact Info

Product

Resources

About