Bladder Treatment

López-Beltrán, Antonio

doi:10.1016/s0094-0143(05)70199-3

Cited by 24 publications

(1 citation statement)

References 58 publications

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“…Wheat et al reported concomitant CIS in 26.7% of nephroureterectomy specimens performed [ 4 ] and CIS was confirmed in the distal ureter in 25% of patients having undergone radical cystectomy [ 5 ]. Lopez-Beltran et al found that patients receiving BCG (Bacillus Calmette-Guerin vaccine) intravesical treatment, who remained recurrence-free in the bladder, were at higher risk of developing UUT-CIS [ 6 ]. Giannarini et al suggested investigating the upper urinary tract (UUT) for missed CIS in all patients who failed BCG treatment of the bladder, as UUT lesions could be detected in more than 50% of cases [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Are we closer to seeing carcinoma in situ in the upper urinary tract?

Kata

Aboumarzouk

2016

CEJU

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IntroductionThere is observed increase in detection rate of upper urinary tract urothelial cancer worldwide. This is a result of improved imaging as well as implementation of novel technologies of direct visualization of upper urinary tract. Standard techniques still remain insufficient to diagnose flat urothelial lesions. Carcinoma in situ is characterized by flat disordered proliferation of urothelial cells with marked cytologic abnormality, which occur within one cell layer as well as full thickness urothelium and therefore requires a better technology to pick up early and subtle mucosal changes.Material and methodsThe review presents available diagnostic tools in detection of upper urinary tract urothelial cancer and their ability to depict carcinoma in situ. ResultsUreterorenoscopy is an investigation of choice as various promising techniques are under pilot investigations to enhance visualization of upper urinary tract carcinoma in situ. So far only photodynamic diagnosis has been reported to be as effective in detection of carcinoma in situ in the upper as within the lower urinary tract.ConclusionsAlthough we are close to see upper urinary tract carcinoma in situ all new promising diagnostic techniques still require further validation in multicenter clinical trials to indicate any change to current recommendations.

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Section: Introductionmentioning

confidence: 99%