Stage pT1 Urothelial Carcinoma

Isolated peripheral nerve sheath tumour involving the urinary bladder neck

“…In most cases reported, bladder tumours were surgically treated with either total or partial cystectomy or transurethral resection. 2,4,5 In conclusion, this is the only peripheral nerve sheath tumour arising from the bladder neck that is reported in literature with recurrent tumour re-growth therefore treatment diagnosis dilemmas arise, such as how frequently to followup, when to re-resect and if there is long-term malignant transformation potential requiring open radical resection.…”

“…Bladder peripheral nerve sheath tumours stain positive for protein S-100 and type IV collagen with immunohistochemistry. 2,4 Some consider both tumours as the same entity whilst others differentiate them, as schwannomas almost never undergo malignant degeneration in comparison to neurofibromas, which may harbour malignant potential, therefore adequate sampling is imperative for the appropriate diagnosis. In literature, a hybrid lesion of neurofibroma/schwannoma is reported which represents a common tumour type in schwannomatosis with a salient association with neurofibromatosis.…”

“…The prevalence of neurofibromas in the genitourinary tract is one in 3000, with slight male predominance and average age of diagnosis 20–30 years old compared to schwannomas, which have age 20 to 50 without predilection to either sex or race. 2 Neurofibromas are associated with neurofibromatosis type 1 (NF1) and von Recklinghausen’s disease whereas schwannomatosis has characteristically multiple spinal, peripheral and cranial-nerve schwannomas and only if vestibular schwannomas are present is there diagnosis of neurofibromatosis type 2 (NF2). 3 These tumours arise from pelvic, bladder and prostatic nerves.…”

“…In most cases reported, bladder tumours were surgically treated with either total or partial cystectomy or transurethral resection. 2,4,5…”