Bladder dysfunction in type 2 diabetic patients

Kebapçı, Nur; Yenilmez, A.; Efe, Belgi̇n; Entok, Emre; Demirüstü, Canan

doi:10.1002/nau.20422

Cited by 124 publications

(87 citation statements)

References 39 publications

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“…These two conditions frequently coexist in the same person, giving rise to great economic and social costs, as well as negatively affecting quality of life. Kebapci et al 18 observed that diabetic cystopathy was the most frequent finding among patients with urinary incontinence, and that it could become established eight or nine years after the initial diagnosis of type 2 diabetes. These authors also demonstrated that the factors predicting the development of diabetic cystopathy were aging, duration of diabetes, retinopathy and microalbuminuria.…”

Section: Resultsmentioning

confidence: 99%

Analysis of the prevalence of and factors associated with urinary incontinence among elderly people in the Municipality of São Paulo, Brazil: SABE Study (Health, Wellbeing and Aging)

Tamanini¹,

Lebrão

Duarte

et al. 2009

Cad. Saúde Pública

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Section: Resultsmentioning

confidence: 99%

Analysis of the prevalence of and factors associated with urinary incontinence among elderly people in the Municipality of São Paulo, Brazil: SABE Study (Health, Wellbeing and Aging)

Tamanini¹,

Lebrão

Duarte

et al. 2009

Cad. Saúde Pública

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“…Non-infectious cystitis can be a complication of autoimmune diseases outside the bladder [1][2][3][4][5][6]. Bladder-originated autoimmunity is also apparent among non-infectious cystitis.…”

Section: Introductionmentioning

confidence: 99%

RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model

Liu

DeYoung

Chen

et al. 2008

Journal of Autoimmunity

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Interstitial cystitis (IC) is a chronic inflammatory condition of the urinary bladder with a strong autoimmune component. Currently, the major challenge in IC treatment is the development of effective therapies. RDP58 is a novel D-amino acid decapeptide with potent immunosuppressive activity. In this study, we investigated whether RDP58 was effective as an intravesical agent for treating bladder autoimmune inflammation in a transgenic mouse model (URO-OVA mice). URO-OVA mice were adoptively transferred with syngeneic activated splenocytes of OT-I mice transgenic for the OVA-specific CD8 + TCR for cystitis induction and treated intravesically with RDP58 at days 0 and 3. Compared with controls, the RDP58-treated bladders showed markedly reduced histopathology and expressions of mRNAs and proteins of TNF-α, NGF and substance P. To determine whether the inhibition of bladder inflammation by RDP58 was due to the interference with effector T cells, we treated the cells with RDP58 in vitro. Cells treated with RDP58 showed reduced production of TNF-α and IFN-γ as well as apoptotic death. Collectively, these results indicate that RDP58 is effective on treating T cell-mediated experimental autoimmune cystitis and may serve as a useful intravesical agent for the treatment of autoimmune-associated bladder inflammation such as IC.

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“…Indeed, it was previously demonstrated that systemic diseases, such as hypertension, has been shown to be another factor related with nocturia both in normal [7][8][9][10] and in patients with T2DM. [12][13][14] However, in all these studies, peripheral BP measurements were evaluated. However, it is now apparent that apart from peripheral BP, central hemodynamic parameters are important for cardiovascular prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed not in all, 11 but some studies have shown that T2DM is associated with nocturia. [12][13][14] The presence of hypertension is common in patients with T2DM. 15 It is also now clear that, apart from peripheral BP, central hemodynamic parameters are important for cardiovascular prognosis.…”

Section: Introductionmentioning

confidence: 99%

Central hemodynamics, vascular stiffness, and nocturia in patients with type 2 diabetes

Afsar

Elsürer

2015

Renal Failure

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Recently, studies have shown that the presence of nocturia may not be a benign condition and related with systemic illness and mortality. Elevated blood pressure (BP) was another factor related with nocturia. Type 2 diabetes mellitus (T2DM) is also associated with nocturia. It is now clear that, apart from peripheral BP, central hemodynamic parameters are important for cardiovascular prognosis. However, no previous study in the literature examined the relationship between nocturia and central hemodynamic parameters in patients with T2DM. The current study was designed to examine these relationships. Nocturia was defined as two or more voids per night. Central hemodynamic parameters were assessed from ambulatory BP measurements. In addition to routine biochemistry, 24-h urine collection was performed to measure protein, albumin, and sodium excretion. 158 patients (52.3%) had T2DM and 144 (47.7%) did not have T2DM (control group). The presence of T2DM was independently related with nocturia. Both in whole group and in T2DM patients, most of the hemodynamic parameters are higher in patients with nocturia compared to patients without nocturia. Among patients with T2DM, nocturia was associated with augmentation index and pulse wave velocity. In conclusion, central hemodynamic parameters and markers of vascular stiffness may be related with nocturia in patients with T2DM.

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Bladder dysfunction in type 2 diabetic patients

Cited by 124 publications

References 39 publications

Analysis of the prevalence of and factors associated with urinary incontinence among elderly people in the Municipality of São Paulo, Brazil: SABE Study (Health, Wellbeing and Aging)

Analysis of the prevalence of and factors associated with urinary incontinence among elderly people in the Municipality of São Paulo, Brazil: SABE Study (Health, Wellbeing and Aging)

RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model

Central hemodynamics, vascular stiffness, and nocturia in patients with type 2 diabetes

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