Bladder carcinogenesis in rats subjected to ureterosigmoidostomy and treated with L-lysine

Dornelas, Conceição Aparecida; Santos, Alessandra Marques dos; Correia, A.; Coelho, João Paulo; Cunha, Bianca Lopes; Maciel, André Vinicius Vieira; Jamacaru, Francisco Vagnaldo Fechine

doi:10.1590/0100-69912016002003

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Similar reductions in the number of goblet cells and mucins were decribed in studies on cystoplasties and urinary diversions in humans 24,28 and animal experiments 29,30. Acid mucin reduction has also been observed in the descending colon of rats submitted to chemical carcinogenesis 31 .…”

Section: ■ Discussionsupporting

confidence: 64%

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

Santos

Coelho²,

Azevedo³

et al. 2017

Acta Cir. Bras.

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Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L-lysine 1 5-Experimental SurgeryActa Cir Bras. 2017;32(3):297-306 Abstract Purpose: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks.Results: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0.045). No inflammatory cells, dysplasia or abnormalities were observed. Staining with Alcian blue revealed a substantial reduction of goblet cells and mucins in the colon segment (Groups A and B). Conclusion:The administration of L-lysine to rats accelerated the development of transitional metaplasia in the epithelium of the colon segment in cystoplasty.

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Section: ■ Discussionsupporting

confidence: 64%

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

Santos

Coelho²,

Azevedo³

et al. 2017

Acta Cir. Bras.

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“…On the other hand, L -lysine failed to promote carcinogenesis in a rat model of bladder cancer submitted to ureterosigmoidostomy and vesico-sigmoidostomy. ( 32 , 33 ) However, L -lysine accelerated the development of transitional metaplasia in intestinal epithelium in rats submitted to cystoplasty. ( 34 )…”

Section: Discussionmentioning

confidence: 99%

Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells

Souza

Braga

Barreto

et al. 2019

Einstein (São Paulo)

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Objective: To evaluate the effect of red propolis and L -lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells. Methods: The study consisted of two experiments with four groups each (total: 57 hamsters). In the experiment 1, the animals were inoculated with Walker tumor cells, followed by administration of test substances (red propolis 200mg/5mL/kg or L -lysine 150mg/kg) or control substances (gum arabic 5mL/kg or water 5mL/kg) for 10 days. The animals in the experiment 2 received red propolis, L -lysine, gum arabic or water at the same doses, for 33 days prior to inoculation of Walker tumor cells, followed by 10 days of treatment with the same substances. Based on single-plane images, angiogenesis was quantified (mean vascular area), in percentage, and tumor area (mm 2 ) and perimeter (mm). Results: In the experiment 1, compared to animals receiving water, the mean vascular area expressed in percentage was significantly smaller in animal treated with propolis (p<0.05) and L -lysine (p<0.001). Conclusion: Both red propolis and L -lysine inhibited tumor angiogenesis in the new hamster cheek pouch model when administered after tumor inoculation.

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Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

Santos¹,

Coelho

Azevedo

et al. 2016

Acta Cir. Bras.

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PURPOSE:To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS:Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H 2 O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H 2 O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue. RESULTS:There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia.CONCLUSION: L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.

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Bladder carcinogenesis in rats subjected to ureterosigmoidostomy and treated with L-lysine

Cited by 3 publications

References 21 publications

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine

Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells

Carcinogenesis in rats subjected to a new model ureterosigmoidostomy and treated with L-lysine

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