2019
DOI: 10.31744/einstein_journal/2019ao4576
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Abstract: Objective: To evaluate the effect of red propolis and L -lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells. Methods: The study consisted of two experiments with four groups each (total: 57 hamsters). In the experiment 1, the animals were inoculated with Walker tumor cells, followed by administration of test substances (red propolis 200mg/5mL/kg or L -… Show more

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Cited by 3 publications
(2 citation statements)
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References 28 publications
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“…In earlier experiments on animal models conducted by our team, red propolis inhibited inflammatory and neoplastic angiogenesis associated with a reduction in inflammatory cells (e.g., mastocytes and macrophages) suggestive of immunomodulatory action (26,27).…”
Section: Discussionmentioning
confidence: 72%
“…In earlier experiments on animal models conducted by our team, red propolis inhibited inflammatory and neoplastic angiogenesis associated with a reduction in inflammatory cells (e.g., mastocytes and macrophages) suggestive of immunomodulatory action (26,27).…”
Section: Discussionmentioning
confidence: 72%
“…In another study, Turkish ethanolic propolis extract induces apoptosis by upregulating proapoptotic protein levels and alters the oncogenic and tumor suppressor gene expression in breast cancer cell lines [94]. A recent report suggested that red propolis along with L-lysine reduces tumor angiogenesis and tumor growth in hamster cheek pouch walker 256 cancer cell-inoculated cancer model [95]. Cuban propolis extracts and active compound nemorosone inhibit cell proliferation and induce apoptosis in doxorubicin-resistant colon cancer cells.…”
Section: Apoptosis-inducing Potential Of Propolis and Its Bioactivementioning
confidence: 98%