Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer

Abstract

To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging, novel Au@Bi 2 S 3 core shell nanobones (NBs) (Au@Bi 2 S 3 NBs) with Au nanorods as cores were synthesized. The combination of Au nanorods with Bi 2 S 3 film made the Au@Bi 2 S 3 NBs exhibit ultrahigh photothermal (PT) conversion efficiency, remarkable photoacoustic (PA) imaging and high computed tomography (CT) performance; these Au@Bi 2 S 3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging. Subsequently, poly(N-vinylpyrrolidone)-modified Au@Bi 2 S 3 NBs (Au@Bi 2 S 3 -PVP NBs) were successfully loaded with the anticancer drug doxorubicin (DOX), and a satisfactory pH sensitive release profile was achieved, thus revealing the great potential of Au@Bi 2 S 3 -PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells. Both in vitro and in vivo investigations demonstrated that the Au@Bi 2 S 3 -PVP NBs possessed multiple desired features for cancer therapy, including extremely low toxicity, good biocompatibility, high drug loading ability, precise tumor targeting and effective accumulation. Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi 2 S 3 -PVP NB-mediated photothermal therapy (PTT). As both a contrast enhancement probe and therapeutic agent, Au@Bi 2 S 3 -PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy.

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

“…The distribution of most nanomaterials with photothermal properties can be detected by PA imaging [ 48 , 49 ], which can serve as a complementary tool for MRI with insufficient resolution [ [50] , [51] , [52] , [53] ]. To further test the diagnosis and treatment potential of PIONs in clinical application, we used three different approaches to measure the imaging property of PIONs both in vivo and in vitro .…”

Gold nanostar‐based complexes applied for cancer theranostics

“…As mentioned, a single modal imaging diagnosis may cause false‐positive signal, 80 single modal therapy is insufficient to achieve complete tumor elimination 106,107 . The emergence of AuNS‐based nanohybrids that integrate multimodal imaging and combination therapy components could improve the diagnosis accuracy and tumor therapy efficiency, 108‐110 contributing to the clinical translation of nanomedicines 4,111 …”

New advances on Au–magnetic organic hybrid core–shells in MRI, CT imaging, and drug delivery

“…Fe 3 O 4 @SiO 2 PrNH 2 @Au Keshtkar et al 37 designed Fe 3 O 4 @Au by magnetic iron oxide nanoparticles through the co-precipitation process, 35 followed by silica according to the Stöber method. 36 45 In the rst step, Au NPs were synthesized 44 and mixed with L-ascorbic acid (AA), hexamethylenetetramine, and thioacetamide (TAA) to give Au NR Au@Bi 2 S 3 NBs as the theranostic agent in cancer therapy, which was added to bismuth acetate to give Au@Bi 2 S 3 core-shell NBs, followed by mixing with PVP to produce Au@Bi 2 S 3 -PVP NBs nano bone as an imaging agent for applying in the tumor cells (Scheme 7). The structure can be used as a nanocarrier for anticancer drugs (DOX) to be released at a special pH.…”