Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review

Huang, Ri-ping; Liu, Ze‐hua; Yin, Hua; Dang, Zhi; Wu, Pingxiao; Zhu, Nengwu; Zhang, Lin

doi:10.1016/j.scitotenv.2018.01.144

Cited by 144 publications

(56 citation statements)

References 121 publications

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“…endocrine disruption) and has thus been banned from use in infant-food containers in various countries including several members of the European Union, China, Japan, Australia, Canada and USA. 316 3.4.2. Cyclic carbonates in epoxy resin applications.…”

Section: Application Of Cyclic and Polymeric Carbonates In The Preparmentioning

confidence: 99%

CO₂-fixation into cyclic and polymeric carbonates: principles and applications

2019

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Section: Application Of Cyclic and Polymeric Carbonates In The Preparmentioning

confidence: 99%

CO₂-fixation into cyclic and polymeric carbonates: principles and applications

2019

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“…Urinary BPA levels were measured because it has been used as a reliable method to monitor human intake of BPA [26,29,30]. The measurements were made four times, at baseline before the intervention and for three menstrual cycles after the intervention.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Dietary Modification Intervention on Menstrual Pain and Urinary BPA Levels: A Single Group Clinical Trial

Park

Chung

2020

Preprint

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Background: Exposure to endocrine-disrupting chemicals (EDCs) occurs mainly through dietary intake. Due to current lifestyle trends, young people tend to consume fast food, to use disposable products, and to utilize convenient household items, all of which are major sources of EDCs. In this study, we investigated the effects of a dietary modification intervention on menstrual pain and urinary bisphenol A (BPA) levels in female college students who experienced severe menstrual pain. In addition, we analyzed participants’ adherence to the intervention and examined whether their level of adherence was associated with differences in the effects of the intervention. Methods: A single-group pretest and repeated posttest experimental design was employed. Thirty female college students with a score of 5 or higher (out of 10) on a menstrual pain scale were recruited through convenience sampling. During three menstrual cycles, menstrual pain was scored on a 10-point scale after each cycle, and urinary BPA levels were measured from the first morning urine collected after each cycle. The intervention involved three components: small-group education, follow-up monitoring, and peer support via social network communication. Statistical analyses were conducted using Friedman one-way repeated-measure analysis of variance by ranks, non-parametric two-way analysis of variance, and the Wilcoxon signed-rank test as a post-hoc test.Results: The dietary modification intervention had significant effects on menstrual pain at all three time points of menstrual cycles (Z=-4.66~-4.56. p=0.000) and on urinary BPA levels until the 2nd menstrual cycle (Z=-3.39~-2.78, p=0.005). Slightly fewer than half (43.3%) of the participants were highly adherent. Menstrual pain differed according to adherence (F=4.67, p=0.032) and decreased over time through the third cycle post-intervention (F=18.30, p=0.000). Urinary BPA levels also decreased significantly (F=7.94, p=0.000). Conclusions: The dietary modification intervention was effective and sustainable for reducing menstrual pain and urinary BPA levels. Detailed information about EDCs and dietary experiences seemed to encourage the young women to become more concerned about EDCs and to perform self-protective actions. Further experimental research is suggested to examine the relationships of EDCs with various health indicators in women. Trial registrationKCT0005472 at 2020-9-24 retrospectively registered.

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“…However, given the uncertainties related to bottom-up approaches, the latest years, there is growing body in literature where BPA daily intake is approximated using urinary BPA levels (Huang et al, 2018). Considering the very rapid metabolism of BPA, it is assumed that a 24-h urine sample approximates the BPA intake from the previous 24 h ( LaKind and Naiman, 2008).…”

Section: Discussionmentioning

confidence: 99%

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

Sarigiannis

Tratnik

Mazej

et al. 2019

Environmental Research

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The current study aims to characterize exposure and risk associated to bisphenol-A (BPA) exposure in Slovenia, starting from biomonitoring data. Based on the urinary data, daily intake for the individuals was back-calculated using a physiology based biokinetic (PBBK) model properly parameterized for BPA, coupled with an exposure reconstruction algorithm. Re-running the PBBK model in forward mode allowed the estimation of biologically effective dose (free plasma BPA) and the respective daily area under the curve (AUC). Finally, risk characterization ratio was derived using both external and internal dose metrics. The urinary BPA levels were found low, with GM of 0.79, 1.51 and 0.20 μg/g creatinine for mothers, children and fathers respectively, similar to the levels of other European countries. Based on the above and accounting for the dynamics of exposure and biokinetics, daily intake was estimated, median exposure levels have been estimated equal to 0.019, 0.035 and 0.005 μg/kg_bw/d for mothers, fathers and children respectively. The highest estimated intake level was found in a child, equal to 0.87 μg/kg_bw/d, while the maximum intake for mothers and fathers were 0.7 and 0.8 μg/ kg_bw/d respectively. The respective RCR levels using the EFSA t-TDI of 4 μg/kg_bw/d were 2 magnitudes of order lower below 1, independently of the selected method. It has to be noted that had daily intake been estimated solely based on the urinary concentrations mass balance, the estimated intake would be lower, as a result of the oversimplification on exposure and elimination time dynamics. This highlights the importance for using PBBK modelling based exposure reconstruction schemes for rapidly metabolized and excreted compounds such as BPA, as well as the study design of efficient sampling for rapidly metabolized compounds.

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Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review

Cited by 144 publications

References 121 publications

CO₂-fixation into cyclic and polymeric carbonates: principles and applications

CO₂-fixation into cyclic and polymeric carbonates: principles and applications

Effects of a Dietary Modification Intervention on Menstrual Pain and Urinary BPA Levels: A Single Group Clinical Trial

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

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Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide: A thorough literature review

Cited by 144 publications

References 121 publications

CO2-fixation into cyclic and polymeric carbonates: principles and applications

CO2-fixation into cyclic and polymeric carbonates: principles and applications

Effects of a Dietary Modification Intervention on Menstrual Pain and Urinary BPA Levels: A Single Group Clinical Trial

Risk characterization of bisphenol-A in the Slovenian population starting from human biomonitoring data

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Product

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CO₂-fixation into cyclic and polymeric carbonates: principles and applications

CO₂-fixation into cyclic and polymeric carbonates: principles and applications