Bismuth Sulfide Nanorods as a Precision Nanomedicine forin VivoMultimodal Imaging-Guided Photothermal Therapy of Tumor

Abstract

Here, we present a precision cancer nanomedicine based on Bi(2)S(3) nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi(2)S(3) NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi(2)S(3) NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

Metal–Organic‐Framework‐Derived Mesoporous Carbon Nanospheres Containing Porphyrin‐Like Metal Centers for Conformal Phototherapy

“…No noticeable particle aggregation or change of morphology was observed after irradiation for 10 min ( Figure S10, Supporting Information), suggesting the dispersions have good stability. Additionally, the photothermal conversion effi ciency ( η ) was calculated as ≈33.0%, much higher than most other photothermal agents such as Au nanorods (21.0%), [ 17 ] Au shells (13.0%), [ 17 ] Bi 2 S 3 nanorods (28.1%), [ 27 ] and Cu 2− x S nanoparticles (16.3%) [ 18 ] ( Figure S11, Supporting Information). The strong photothermal conversion capacity and excellent photo stability of PMCS suggest that they have great potential as photo thermal agents.…”

Bismuth Sulfide (Bi2S3) Nanorods as Efficient Photodetection Materials

“…In recent years, nanosized Bi 2 S 3 of various morphologies and sizes has been used as promising materials in photovoltaics (solar cell) [2], photodetection [3][4][5], photocatalysis [6], photothermal conversion [7], thermoelectrics [8], and so on. In particular, much attention is being paid on one-dimensional (1D) rod-like Bi 2 S 3 nanomaterials and their optical and photoelectronic performance.…”

Multifunctional Cu1.94S-Bi2S3@polymer nanocomposites for computed tomography imaging guided photothermal ablation

“…Compared to the commonly used small molecule CT contrast agents such as iodinated molecules [12] that often suffer from short imaging time and potential renal toxicity by their rapid kidney's clearance [13][14][15], the nanocrystal contrast agents such as Bi 2 S 3 , TaO x and Au nanoparticles (NPs) show several advantages including low toxicity, long imaging time, and high absorption coefficient [16][17][18]. In particular, bismuth-based NPs such as Bi 2 Se 3 nanoplates and Bi 2 S 3 nanorods have drawn significant attention [19,20], because bismuth element possesses high X-ray attenuation coefficient resulted from its high density (ρ) and atomic number (Z) [21]. Recently, Rabin et al [22] synthesized Bi 2 S 3 nanoplates which showed long vascular half-life and had considerable potential to achieve enhanced CT efficacy with a lower agent dose in the future clinical applications.…”

“…In the light of broad NIR absorption, high photothermal conversion efficiency (PCE), low cost, good photostability and excellent biocompatibility, copper chalcogenides (Cu 2−x S) have become a type of promising candidate to meet severe demands of photothermal ablation [29][30][31][32]. Most recently, our group has reported the synthesis of ultrahigh 19 F loaded Cu 1.75 S nanoprobes with small particle size (average size~21 nm) for simultaneous 19 F magnetic resonance imaging (MRI) and PTT [33,34]. As for CT imaging-guided PTT [35,36], although much efforts have recently been concentrated on pursuing nanomaterials with not only the capacity of photothermal conversion but also CT imaging responses, some challenges remain to be addressed.…”

“…For example, WO 3−x and gold nanorods possess both NIR and CT responses [12,23], but the NIR response resulted from oxygen vacancies on the surface of WO 3−x is easy to disappear with oxidization happened in the ambient environment; and due to the "melting effect", the NIR absorbance peak and thus photothermal effects of gold nanorods will diminish after a long period of laser irradiation [37][38][39]. Additionally, Bi 2 S 3 and Cu-Bi-S ternary nanocrystals such as Cu 3 BiS 3 have been reported for dual-functional CT imaging and PTT [19,36,40]. However, the exploration and construction of ternary Cu-Bi-S nanomaterials with both strong NIR absorption and CT response is very limited because of their complicated stoichiometry and difficult preparation [36,40].…”