Metal–Organic‐Framework‐Derived Mesoporous Carbon Nanospheres Containing Porphyrin‐Like Metal Centers for Conformal Phototherapy

Wang, Shunhao; Shang, Lu; Li, Linlin; Yu, Yingjie; Chi, Chongwei; Wang, Kun; Zhang, Jie; Shi, Run; Shen, Heyun; Waterhouse, Geoffrey I. N.; Liu, Sijin; Hui, Hui; Zhang, Tierui; Liu, Huiyu

doi:10.1002/adma.201602197

Cited by 270 publications

(194 citation statements)

References 58 publications

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“…Interestingly,t he Zn À N À CS Azymes served as photosensitizers and could also be utilized for photodynamic therapy (PDT;F igure 7C). [91] Owing to the zinc-centered porphyrin-like structure,t he singlet oxygen quantum yield of Zn À N À CS Azymes was comparable with commercial indocyanine green. Moreover,c ompared with individual mesoporous carbon spheres,t he ZnÀNÀCS Azymes exhibited high photothermal conversion efficiency.P hotodynamic/ photothermal synergetic therapy using Zn À N À CS Azymes promoted ad ramatic tumor regression in nude mice.…”

Section: Methodsmentioning

confidence: 89%

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When Nanozymes Meet Single‐Atom Catalysis

et al. 2019

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Nanomaterials with enzyme‐like activities, coined nanozymes, have been researched widely as they offer unparalleled advantages in terms of low cost, superior activity, and high stability. The complex structure and composition of nanozymes has led to extensive investigation of their catalytic sites at an atomic scale, and to an in‐depth understanding of the biocatalysis occurring. Single‐atom catalysts (SACs), characterized by atomically dispersed active sites, have provided opportunities for mimicking metalloprotease and for bridging the gap between natural enzymes and nanozymes. In this Minireview, we illustrate the unique properties of nanozymes and we discuss recent advances in the synthesis, characterization, and applications of SACs. Subsequently, we outline the impressive progress made in single‐atom nanozymes and we discuss their applications in sensing, degradation of organic pollutants, and in therapeutic roles. Finally, we present the major challenges and opportunities remaining for a successful marriage of nanozymes and SACs.

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Section: Methodsmentioning

confidence: 89%

“….C opyright, 2019, Wiley-VCH.C)Zn ÀNÀCSAzymes employed in photodynamic/ photothermalsynergetic therapy;n ear-infrared (NIR) light. Reprinted with permission from ref [91]…”

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confidence: 99%

When Nanozymes Meet Single‐Atom Catalysis

et al. 2019

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“…In addition, the photothermal properties of PtFeNRs and Fe 3 O 4 NPs were also investigated ( Figure S4). Thee levated temperature of the PtFe@Fe 3 O 4 NRs suspension (29.2 8 8C) was slightly lower than that of the PtFeNRs (31.5 8 8C), [30] which may be due to the Fe 3 [31] (Table S2) ). [32] The K M value of the PtFe@Fe 3 According to the Arrhenius formula, the surface plasmon resonance (SPR) effect of noble metals could effectively convert NIR light energy to heat energy,which could promote the catalytic reaction.…”

Section: Resultsmentioning

confidence: 90%

A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

Shang

et al. 2019

Angewandte Chemie

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Nanozymes have attracted extensive interest owing to their high stability,low cost and easy preparation, especially in the field of cancer therapy. However,t he relatively low catalytic activity of nanozymes in the tumor microenvironment (TME) has limited their applications.Herein, we report anovel nanozyme (PtFe@Fe 3 O 4 )w ith dual enzyme-like activities for highly efficient tumor catalytic therapy. PtFe@Fe 3 O 4 shows the intrinsic photothermal effect as well as photo-enhanced peroxidase-like and catalase-like activities in the acidic TME, therebye ffectively killing tumor cells and overcoming the tumor hypoxia. Importantly,apossible photo-enhanced synergistic catalytic mechanism of PtFe@Fe 3 O 4 was first disclosed. We believe that this work will advance the development of nanozymes in tumor catalytic therapy.

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“…At 4h,P FN Ps distributed outside the cells and remained in af luorescence quenching state, indicating their PTT efficacy.A t2 4h,P FN Ps were distributed inside cellsa nd completely disassembled into monomers, signifying their PDT efficacy,a nd the cells were kept in an ice-bath duringi rradiation. [19] After that, the cell viability was investigated by using as tandard 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay (Figure 4e). Single PDT or PTT showedc omparable cytotoxicity toward MCF-7 cells, confirming the photoactivity of both the photothermal PF NPs and disassembled photodynamic PF monomers.…”

Section: Resultsmentioning

confidence: 99%

Spatiotemporally Coupled Photoactivity of Phthalocyanine–Peptide Conjugate Self‐Assemblies for Adaptive Tumor Theranostics

Zhao

Chang

et al. 2019

Chemistry A European J

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Spatiotemporally coupled tumor phototheranostic platforms offer a flexible and precise system that takes the biological interaction between tumors and photoactive agents into consideration for optimizing treatment, which is highly consistent with precision medicine. However, the fabrication of monocomponent‐based photoactive agents applicable to multifold imaging techniques and multiple therapies in a facile way remains challenging. In this study, we developed simple phthalocyanine–peptide (PF) conjugate‐based monocomponent nanoparticles with spatiotemporally coupled photoactivity for adaptive tumor theranostics. The self‐assembled PF nanoparticles possess well‐defined spherical nanostructures and excellent colloidal stability along with supramolecular photothermal effects. Importantly, the PF nanoparticles showed switchable photoactivity triggered by their interactions with the cell membrane, which enables an adaptive transformation from photothermal therapy (PTT) and photoacoustic imaging (PAI) to photodynamic therapy (PDT) and corresponding fluorescence imaging (FI). Theranostic modalities are integrated in a spatiotemporally coupled manner, providing a facile, biocompatible and effective route for localized tumor phototherapy. This study offers a flexible and versatile strategy to integrate multiple theranostic modalities into a single component so that it can realize its full potential and thereby amplify its therapeutic efficacy, creating promising opportunities for the design of theranostics and further highlighting their clinical prospects to the diagnosis and treatment of cancers.

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Metal–Organic‐Framework‐Derived Mesoporous Carbon Nanospheres Containing Porphyrin‐Like Metal Centers for Conformal Phototherapy

Cited by 270 publications

References 58 publications

When Nanozymes Meet Single‐Atom Catalysis

When Nanozymes Meet Single‐Atom Catalysis

A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

Spatiotemporally Coupled Photoactivity of Phthalocyanine–Peptide Conjugate Self‐Assemblies for Adaptive Tumor Theranostics

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