A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

Li, Shanshan; Shang, Lu; Xu, Bolong; Wang, Shunhao; Gu, Kai; Qu, Wu; Sun, Yun; Zhang, Qinghua; Yang, Hailong; Zhang, Fengrong; Gu, Lin; Zhang, Tierui; Liu, Huiyu

doi:10.1002/ange.201904751

Cited by 76 publications

(32 citation statements)

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“…The intrinsic catalytic activity enables nanozymes to regulate TME via changing RONS content or eliminating hypoxia [ 43 , 408 – 410 ]. The biological safety, photothermal performance and some other physicochemical properties of nanozymes also indicated their potential in cancer therapy [ 411 ]. Given these reasons, nanozymes have been regarded as the prospective standalone agents or synergist for the progress of tumor treatment [ 43 ].…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

“…14 b). Li et al [ 411 ] prepared the H 2 O 2 -responsive PtFe@Fe 3 O 4 , which possessed POD-like activity, CAT-type property and exceptional photothermal performance under acidic TME environment. Experimental results indicated that tumor catalytic therapy based on PtFe@Fe 3 O 4 nanozymes obtained a 99.8% anti-tumor rate for deep pancreatic cancer when cooperating with photothermal therapy What is more, the electron transfer process between PtFe nanorods, Fe 3 O 4 NPs and H 2 O 2 molecules was also firstly described in their study (Fig.…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

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A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…ue to their exclusive catalytic activity and selectivity, artificial enzymes are exploited as promising tools for wide-reaching biomedical implications [1][2][3][4][5][6][7][8] , particularly as advanced diagnostics 9,10 and therapeutics [11][12][13][14][15][16] of diseases. Earlier studies shed light on the oxidase-and peroxidase-like activities of noble metals 17 .…”

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confidence: 99%

Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

et al. 2021

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Emerging artificial enzymes with reprogrammed and augmented catalytic activity and substrate selectivity have long been pursued with sustained efforts. The majority of current candidates have rather poor catalytic activity compared with natural molecules. To tackle this limitation, we design artificial enzymes based on a structurally well-defined Au25 cluster, namely clusterzymes, which are endowed with intrinsic high catalytic activity and selectivity driven by single-atom substitutions with modulated bond lengths. Au24Cu1 and Au24Cd1 clusterzymes exhibit 137 and 160 times higher antioxidant capacities than natural trolox, respectively. Meanwhile, the clusterzymes demonstrate preferential enzyme-mimicking catalytic activities, with Au25, Au24Cu1 and Au24Cd1 displaying compelling selectivity in glutathione peroxidase-like (GPx-like), catalase-like (CAT-like) and superoxide dismutase-like (SOD-like) activities, respectively. Au24Cu1 decreases peroxide in injured brain via catalytic reactions, while Au24Cd1 preferentially uses superoxide and nitrogenous signal molecules as substrates, and significantly decreases inflammation factors, indicative of an important role in mitigating neuroinflammation.

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“…Moreover, the Au NPs depleted glucose and produced large amount of H 2 O 2 , resulting in enhanced Fenton reaction catalyzed by Fe 2+ of MOFs. In yet another study, the nanozyme made of PtFe@Fe 3 O 4 exhibited dual enzyme-like activities of both intrinsic peroxidase-like and catalase-like activities in the acidic TME [ 52 ]. On the one hand, the prepared nanozyme promoted ROS production by direct electron transfer and Fe 3+ -mediated Fenton reaction.…”

Section: Fenton and Fenton-like Reactions-mediated Combination Therapymentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

Cited by 76 publications

References 51 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

Chemodynamic nanomaterials for cancer theranostics

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