Bismuth complex of quinoline thiosemicarbazone restores carbapenem sensitivity in NDM-1-positive Klebsiella pneumoniae

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

“…These results suggest that thiosemicarbazone complexes with bismuth (Bi) (III) may be an interesting and effective anti-lung cancer drug candidate. The coordination of Bi complexes 110–117 is a thiosemicarbazone containing a quinoline group ( Scheme 11 ) ( Scaccaglia et al, 2022 ). Among them, complexes 113 and 114 show significant inhibitory activities against the A549 cell line with IC 50 values of 5.05 ± 1.79 μM and 46.96 ± 16.66 μM, respectively.…”

Heteroleptic six-coordinate bismuth(iii) complexes with 2-acetylthiophene thiosemicarbazones: synthesis, characterization, and biological properties

“…15 Although there are many studies in the literature covering the compounds formed by TSCs with transition metals, [16][17][18][19][20][21][22] the number of studies on the compounds formed by these ligands with pnictogen elements is few. [23][24][25] Among the pnictogen elements, bismuth has an important position because it is safe and non-toxic. Today, the leading goal of many research groups is to synthesize new bismuth-containing compounds with antibacterial and anticancer properties.…”

“…Scaccaglia et al stated that bismuth complexes of general formula BiLCl 2 , where L is a thiosemicarbazone bearing a quinoline moiety, showed anticancer activity against A549 human lung carcinoma cells. 23 In the study by Khan et al , the effects of a series of binuclear Bi( iii ) chloride 2-acetyl-3-ethylpyrazine thiosemicarbazone complexes against human bladder cancer cells (T24) were investigated. 32 We have presented that the bismuth( iii ) halide complexes of thiophene-2-carbaldehyde-N-substituted thiosemicarbazones show effective activity against the human breast adenocarcinoma (MCF-7) cell line.…”

One-Year Water-Stable and Porous Bi(III) Halide Semiconductor with Broad-Spectrum Antibacterial Performance

“…58 Scaccaglia et al assembled a series of complexes with the general formula BiLCl 2 (L is a quinoline thiosemicarbazone) with bactericidal activity against Klebsiella pneumonia (K. pneumonia). 59 Despite their performance, a vast majority of the reported compounds do not exhibit water stability. This trait can hinder their broad utilization in applications beyond therapeutics, from water purification and disinfection, 60 personal protective equipment (PPE) antibacterial coatings, 61 and antibacterial coatings in respirators 62 to food packaging applications.…”

“…aeruginosa . Scaccaglia et al assembled a series of complexes with the general formula BiLCl 2 (L is a quinoline thiosemicarbazone) with bactericidal activity against Klebsiella pneumonia ( K. pneumonia ) …”