Heteroleptic six-coordinate bismuth(iii) complexes with 2-acetylthiophene thiosemicarbazones: synthesis, characterization, and biological properties

Abstract

The present study aimed to prepare and then evaluate the antiproliferative and antibacterial activities of bismuth(III) thiosemicarbazone complexes. Five bismuth(III) halide complexes of general formulae [BiX3(HL)3] (X: Cl; 1 and...

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

“…For example, Ozturk et al reported recently several Bi 3+ coordinated in an S-monodentate fashion to thiosemicarbazone and other ligands, finding that most of them give no significative cytotoxicity against MCF-7 cells, IC 50 (48 h) > 30 µM, and some of them presented moderate activity, IC 50 (48 h) = 5.4-8.0 µM, against this cancer cell line [154][155][156][157]. Very recently, this research group reported five Bi 3+ halide complexes with thiosemicarbazone bearing an acetylthiophene moiety that presented moderate cytotoxicity on HeLa cells (IC 50 4.5-24.3 µM) [158]. They also reported several Bi 3+ complexes coordinated in an S-monodentate mode to thioamide ligands that showed low to moderate activity against human adenocarcinoma cells, HeLa (cervix) and MCF-7 (breast), with most IC 50 (48 h) values superior to 30 µM [159,160].…”

Fabrication of thiosemicarbazone-based Pd(ii) complexes: structural elucidations, catalytic activity towards Suzuki–Miyaura coupling reaction and antitumor activity against TNBC cells

“…Thiosemicarbazones are a class of N, S-donor ligands that have been widely employed in coordination chemistry because of their structural adaptability and versatility, since they can exist as thione-thiol tautomers, and accordingly, can bind to metal centres as monodentate, bidentate, or bridging ligands. 1,2 Due to their pharmacological characteristics, particularly as antiphrastic, antibacterial, antioxidant, and anticancer agents, thiosemicarbazone derivatives and their metal complexes have attracted significant interest in chemistry and biology. 3–8 Specifically, heterocyclic thiosemicarbazones derived by condensation between the carbonyl of a heterocyclic moiety and thiosemicarbazide can form pincer-type complexes with suitable metal ions, as they can act as O,N,S- or N,N,S-donor chelating ligands.…”