Bismuth-Based Nano- and Microparticles in X-Ray Contrast, Radiation Therapy, and Radiation Shielding Applications

Winter, Hayden; Brown, Anna L.; Goforth, Andrea M.

doi:10.5772/intechopen.76413

Cited by 10 publications

(7 citation statements)

References 39 publications

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“…1 Illustration of a high-Z bismuth nanoparticle (BiNP) (for example, a 50 nm BiNP consists of about 1 million Bi atoms). The targeting vector is selected to have a high degree of specificity for a biological receptor, including a cell surface protein (Winter et al 2018 ) …”

Section: Binps Properties and Performancementioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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Bismuth (Bi) combinations have been utilized for the treatment of bacterial infections. In addition, these metal compounds are most frequently utilized for treating gastrointestinal diseases. Usually, Bi is found as bismuthinite (Bi sulfide), bismite (Bi oxide), and bismuthite (Bi carbonate). Newly, Bi nanoparticles (BiNP) were produced for CT imaging or photothermal treatment and nanocarriers for medicine transfer. Further benefits, such as increased biocompatibility and specific surface area, are also seen in regular-size BiNPs. Low toxicity and ecologically favorable attributes have generated interest in BiNPs for biomedical approaches. Moreover, BiNPs offer an option for treating multidrug-resistant (MDR) bacteria because they communicate directly with the bacterial cell wall, induce adaptive and inherent immune reactions, generate reactive oxygen compounds, limit biofilm production, and stimulate intracellular impacts. In addition, BiNPs in amalgamation with X-ray therapy as well as have the capability to treat MDR bacteria. BiNPs as photothermal agents can realize the actual antibacterial through continuous efforts of investigators in the near future. In this article, we summarized the properties of BiNPs, and different preparation methods, also reviewed the latest advances in the BiNPs’ performance and their therapeutic effects on various bacterial infections, such as Helicobacter pylori , Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli . Graphical abstract: BiNPs are antibacterial and ideal photothermal agents to inhibit various bacterial infections

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Section: Binps Properties and Performancementioning

confidence: 99%

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

“…XCA (X-ray contrast agent) containing bismuth (like Bi2S3) nanoparticle coated with PVP (polyvinyl pyrrolidone) increased the computed tomography (CT) brightness, even at lower concentrations, as compared to the iodine-based clinical contrast agent, iopromide. The blood circulation half-life of PVP-coated Bi2S3 nanoparticles was significantly larger than the iodinated counterparts [46].…”

Section: Radiation Therapymentioning

confidence: 90%

Nanoparticles in Clinical Translation for Cancer Therapy

Mundekkad

Cho

2022

IJMS

125

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The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. The new therapeutic modalities accomplished through the properties of nanomaterials have extended their scope in cancer therapy beyond conventional drug delivery. Nanoparticles can be channeled in cancer therapy to encapsulate active pharmaceutical ingredients and deliver them to the tumor site in a more efficient manner. This review enumerates various types of nanoparticles that have entered clinical trials for cancer treatment. The obstacles in the journey of nanodrug from clinic to market are also reviewed. Furthermore, the latest developments in using nanoparticles in cancer therapy are also highlighted.

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“…To overcome all these concerns, lead-free protective materials have been proposed and introduced in the radiation protection industry as lighter-weight and non-toxic materials [11,. Lead-free composite materials containing radiation-shielding metals, such as bismuth (Bi) [38][39][40][41][42][43][44][45][46][47], barium (Ba) [47][48][49][50], tungsten (W) [51][52][53][54][55][56][57], antimony (Sb) [58], tin (Sn) [59], and others, dispersed in a polymer matrix, usually provide X-ray protection in a narrower range of photon energies than Pb, which depends on their atomic Z-number and K-absorption edge [11,13]. Different composite material structures and protective garment designs, where the shielding metals are arranged into a single-layer, bilayer, or multi-layer structure, have been proposed for efficient shielding against scatter and primary X-rays [24][25][26][27][28]60,61].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Attenuation Properties of Commercial Lead-Free Radiation-Shielding Composite Materials Against Medical X-rays

Trajkovska Petkoska

2023

J. Compos. Sci.

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Six commercial, lead-free, radiation protective materials were tested for their attenuation across a range of X-ray energies used in medical diagnostic imaging and interventional radiology. While all the tested materials showed the specified attenuation at the X-ray energy claimed by their manufacturers, only two of the materials showed satisfactory attenuation in an extended range of medical X-ray energies (generated in X-ray tubes with voltages between 50 and 150 kV). The lead-free materials are lighter than the lead-containing materials, which is very important for those wearing the radiation protective garments for an extended time; however, the main focus in the promotion of radiation-shielding materials should still be on their attenuation efficacy against both the primary and the scattered X-rays present in medical environments. The end users should be informed on the material attenuation in an extended energy range, especially in the range where scatter radiation occurs, and not just about the peak material attenuation performance at energies where the X-rays are generated. Scatter radiation is the main reason for the occupational radiation exposure of medical personnel, who should have the whole picture about the shielding ability of the protective garments that they strongly rely on.

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Bismuth-Based Nano- and Microparticles in X-Ray Contrast, Radiation Therapy, and Radiation Shielding Applications

Cited by 10 publications

References 39 publications

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Nanoparticles in Clinical Translation for Cancer Therapy

Assessment of the Attenuation Properties of Commercial Lead-Free Radiation-Shielding Composite Materials Against Medical X-rays

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