Bismuth and Silver Nanoparticles as Antimicrobial Agent over Subgingival Bacterial and Nosocomial Strains

Abstract

Bismuth compounds are used in the treatment of gastrointestinal infections due to its effectiveness against Helicobacter pylori as Gram-negative bacteria. Moreover, the nanometric materials show better biological properties that the materials in block. The aim of this study was to determine the MICs (minimal inhibitory concentrations) of three colloidal dispersions of bismuth nanoparticles compared with silver nanoparticles against oral and nosocomial bacteria. The nanoparticles were synthesized by chemical reduction in DMSO. The MICs of each colloidal dispersion were obtained on eight species representative of the subgingival biofilm, as well as in three species of medical importance: Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. All bismuth compounds showed antimicrobial effect on the tested bacterial species, with MICs between 37 to 329 µg/mL. On the other hand, AgNPs showed MICs from 16 to 32 µg/mL for the bacteria of subgingival biofilm and from 32 to 65 µg/mL for the species of medical importance. In accordance with this study, the different BiNPs had an antimicrobial effect in all the bacterial species, although with a potency lower than AgNPs. to the dental surface by means of specific molecules [5,6], such as Streptococcus spp and Actinomyces spp. Then, the bridge settlers or secondary bacteria, which include species like Fusobacterium nucleatum,

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

“…While less powerful than AgNPs, Bi 2 O 3 NPs were the most potent nanometric Bi compounds tested here. (Campos et al 2018 ) Bi(NO 3 ) 3 NP P. aeruginosa These NPs improve localized X-ray dose by 35 times higher than the control with no NPs. Bi(NO 3 ) 3 NP is a semiconductor photocatalyst with the advantages of low cost, low toxicity, high light stability, and photo corrosion.…”

“…Nevertheless, AgNPs revealed MICs between 16 and 32 µg/mL against bacteria in subgingival biofilm and between 32 and 65 µg/mL against medically essential species. The Bi 2 O 3 NPs became the most effectual nanometric Bi compounds that were examined for this study, although having a lesser strength than AgNps (Campos et al 2018 ).…”

Probing the effect of lightly doped Iron in Bi2S3 nanostructures on Physiochemical properties and efficacy in anti-microbial activity

“…Despite being a heavy metal, bismuth is non-toxic to humans [23] and has anti-microbial and biological applications [24]. When contrast to silver nanostructures, bismuth compounds have differing antibacterial effects on bacteria [25]. Many transition metals, such as Mn, Se, Cl, Ni, Fe, and Co [11,[26][27][28][29][30] are employed to improve the ability of nanostructures, according to literature.…”

Antimicrobial activity, viability, and physicochemical properties of an MTA-type cement with different concentrations of bismuth trioxide

“…In this sense, bismuth has been studied as an antimicrobial agent, mainly in bismuth subsalicylate compound [15]. In this regard, the studies that evaluate its antimicrobial capacity offer contradictory results [16][17][18], but Bi 2 O 3 displays remarkable antibacterial activity and low cytotoxicity [19,20]. Nevertheless, the effect of Bi 2 O 3 as part of MTA cement on the cell viability and as an antimicrobial agent has not been evaluated.…”