Bismuth

Himeno, Seiichiro; Fujishiro, Hitomi; Sumi, Daigo

doi:10.1016/b978-0-12-822946-0.00005-2

Cited by 4 publications

(5 citation statements)

References 159 publications

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“…However, commercially available bismuth compounds such as BSS, CBS, and RBC are not readily soluble in the stomach's acidic environment (pH 2), leading to poor absorption of Bi 3+ ions into the bloodstream. This results in limited bioavailability, with less than 1% of orally ingested bismuth being absorbed and quickly excreted in the urine [20]. Thus, studies have shown that even with multiple doses, the maximum plasma concentration of bismuth remains below the toxic threshold of 50 µg L −1 [21][22][23].…”

Section: Bioavailability Challenges Associated With Bismuth-based Com...mentioning

confidence: 99%

“…Furthermore, Andleeb et al evaluated a series of eight heteroleptic triorganobismuth(V) biscarboxylates (20)(21)(22)(23)(24)(25)(26)(27) for their anti-leishmanial potential against Leishmania tropica KWH23 strains. The low IC 50 values (<1 µM) revealed that the complexes are highly active, except for 25 (IC 50 = 20 µM).…”

Section: Antiparasitic Activitymentioning

confidence: 99%

“…Thiol chelation generally improves the solubility and lipophilicity of bismuth-based compounds [122], thus resulting in the potentiation of the antitumoral activity, as observed for antimicrobial activity. The greater thermodynamic stability of Bi-S compounds compared to Bi-O compounds and the relative Bi-S low lability give thiobismuth compounds broad biological applicability [20,32]. Since thiobismuth compounds can promptly exchange with free thiols due to a kinetically labile Bi-S bond, Bi 3+ has high mobility inside cells, making it more suitable for reaching the desired biological targets.…”

Section: Bismuth(iii) Complexes Bearing S-donor Ligandsmentioning

confidence: 99%

See 2 more Smart Citations

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

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Bismuth-based drugs have been used primarily to treat ulcers caused by Helicobacter pylori and other gastrointestinal ailments. Combined with antibiotics, these drugs also possess synergistic activity, making them ideal for multiple therapy regimens and overcoming bacterial resistance. Compounds based on bismuth have a low cost, are safe for human use, and some of them are also effective against tumoral cells, leishmaniasis, fungi, and viruses. However, these compounds have limited bioavailability in physiological environments. As a result, there is a growing interest in developing new bismuth compounds and approaches to overcome this challenge. Considering the beneficial properties of bismuth and the importance of discovering new drugs, this review focused on the last decade’s updates involving bismuth compounds, especially those with potent activity and low toxicity, desirable characteristics for developing new drugs. In addition, bismuth-based compounds with dual activity were also highlighted, as well as their modes of action and structure–activity relationship, among other relevant discoveries. In this way, we hope this review provides a fertile ground for rationalizing new bismuth-based drugs.

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Section: Bioavailability Challenges Associated With Bismuth-based Com...mentioning

confidence: 99%

Section: Antiparasitic Activitymentioning

confidence: 99%

Section: Bismuth(iii) Complexes Bearing S-donor Ligandsmentioning

confidence: 99%

See 1 more Smart Citation

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Rosário,

Moreira,

Rosa

et al. 2023

Molecules

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“…3 °C and the boiling point is 1560 AE 5 °C; the thermal expansion coefficient of bismuth is 3.3% and its matrix is soft; bismuth has poor electrical conductivity and thermal conductivity, weak radioactivity, and a trace of toxicity. [41] The physical and mechanical properties of bismuth are shown in Table 1 and 2, [42] respectively.…”

Section: Bismuthmentioning

confidence: 99%

“…Bismuth (Bi) is a silver‐white to shallow‐yellow metal element listed in the sixth periodic VA, with an atomic number of 83 and relative atomic mass of 209; its melting point is 271.3 °C and the boiling point is 1560 ± 5 °C; the thermal expansion coefficient of bismuth is 3.3% and its matrix is soft; bismuth has poor electrical conductivity and thermal conductivity, weak radioactivity, and a trace of toxicity. [ 41 ] The physical and mechanical properties of bismuth are shown in Table 1 and 2 , [ 42 ] respectively.…”

Section: Bismuthmentioning

confidence: 99%

Forms and Roles of Bismuth in Steel: A Review

Xie

2022

steel research int.

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Bismuth (Bi), as a green free-cutting metal element, has been used for the production of free-cutting steels in the field of free-cutting steel for a couple of decades. One of the merits of bismuth is to improve the machinability of steel, while more Bi addition to steel causes cracking of steels during thermal rolling, attributed to the formation of liquid Bi films. Due to a lack of summary, people have limited mastering the Bi-bearing steels. Herein, the forms and roles of Bi in steel based on the literature survey are summarized. These specific reviews concentrate on the forms, mechanical properties, segregation, solidification, and solubility of Bi in steel, and the effect on grain, machinability, and thermal expansion of steel is also reviewed. This review is of great significance in advancing the understanding of Bi-bearing steels.

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RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

Sedigh

Gholipour

Zandi

et al. 2023

World J Microbiol Biotechnol

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Bismuth (Bi) combinations have been utilized for the treatment of bacterial infections. In addition, these metal compounds are most frequently utilized for treating gastrointestinal diseases. Usually, Bi is found as bismuthinite (Bi sulfide), bismite (Bi oxide), and bismuthite (Bi carbonate). Newly, Bi nanoparticles (BiNP) were produced for CT imaging or photothermal treatment and nanocarriers for medicine transfer. Further benefits, such as increased biocompatibility and specific surface area, are also seen in regular-size BiNPs. Low toxicity and ecologically favorable attributes have generated interest in BiNPs for biomedical approaches. Moreover, BiNPs offer an option for treating multidrug-resistant (MDR) bacteria because they communicate directly with the bacterial cell wall, induce adaptive and inherent immune reactions, generate reactive oxygen compounds, limit biofilm production, and stimulate intracellular impacts. In addition, BiNPs in amalgamation with X-ray therapy as well as have the capability to treat MDR bacteria. BiNPs as photothermal agents can realize the actual antibacterial through continuous efforts of investigators in the near future. In this article, we summarized the properties of BiNPs, and different preparation methods, also reviewed the latest advances in the BiNPs’ performance and their therapeutic effects on various bacterial infections, such as Helicobacter pylori , Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli . Graphical abstract: BiNPs are antibacterial and ideal photothermal agents to inhibit various bacterial infections

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Bismuth

Cited by 4 publications

References 159 publications

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

Forms and Roles of Bismuth in Steel: A Review

RETRACTED ARTICLE: The role of bismuth nanoparticles in the inhibition of bacterial infection

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