Bis(oxalato)dioxovanadate(V) and Bis(oxalato)oxoperoxo-vanadate(V) Complexes: Spectroscopic Characterization and Biological Activity

Abstract

Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2] · 3H2O and K3[VO(O2)(C2O4)2] · 1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.

New vanadium complexes with 6,6″-dimethyl-2,2′:6′,2″-terpyridine in terms of structure and biological properties

“…As reported earlier, possible cytotoxicity mechanism of vanadium complexes goes through generation of reactive oxygen species (ROS) which may damage cell organelles in vivo [57,58]. (12) 179.67 (9) 134.64 (7) 131.20(7) N1-V1-N14 148.19 (11) 147.71 (8) 150.32 (7) 150.03(8) Cl1-V1-Cl2 167.43 (4) 169…”

“…Furthermore, those ligands were used to assess mechanism and kinetics of ligand substitution for vanadium(V) bisperoxido complexes -potential antitumour agents [8]. The latter class of compounds has been put under research from different angles, encompassing for instance their impact on viability of the human MG-63 osteosarcoma cells [9], chiral Schiff-base l-oxido complex that binds both to CT-DNA and bovine serum albuminum (BSA) [10] or catalytic oxidation of hydrocarbons [11]. Transition metal complexes of various N-heterocyclic scaffolds have been related to such areas of research as catalysis [12] or photovoltaics [13], nevertheless one of the most promising domain of studies involves bioassays.…”

Synthesis and structural study of tris(2,6-diaminopyridinium) bis(oxalato)dioxidovanadate(V) 2.5-hydrate

“…The coordination chemistry of vanadium has received great attention during the last few decades. Many vanadium complexes of the oxalate dianion have been reported having biological (Kordowiak et al, 2000;Leó n et al, 2013) and catalysis applications (Mishra et al, 2002;Maurya et al, 2003). Many non-polymeric structural architectures of vanadium oxalate compounds have been reported, among which the synthesis of mononuclear bis(oxalato)dioxovanadate(V) complexes is limited to the easy formation of aquabis-(oxalato)oxidovanadate(IV) (Lin et al, 2004, Aghabozorg et al, 2007, Sehimi et al, 2016.…”

An oxalate-bridged oxidovanadium(IV) binuclear complex that improves the in vitro cell uptake of a fluorescent glucose analog

“…[15,16]. The bioinorganic relevance of vanadiumoxalate chemistry, in its turn, has been addressed in a variety of levels [16][17][18]. Under physiological conditions, vanadium(IV) has a high affinity for O-donor bioligands as lactate, citrate and oxalate, which prevents hydrolysis and precipitation of insoluble VO(OH) 2 [19].…”