An oxalate-bridged oxidovanadium(IV) binuclear complex that improves the in vitro cell uptake of a fluorescent glucose analog

Baptistella, Gabriel Barros; Manica, Graciele Cristiane More; Souza, Susan Webber de; Santana, Francielli Sousa; Fachini, Lucas G.; Hughes, David L.; Sá, Eduardo L. de; Picheth, Geraldo; Soares, Jaı́sa F.; Nunes, Giovana G.

doi:10.1016/j.poly.2021.115071

Cited by 6 publications

(10 citation statements)

References 65 publications

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“…To ensure that the synthesized compound was the same compound used by Baptistella et al [ 48 ], confirmatory tests were carried out. The original synthesis was carried out by scaling the amounts of reactants and solvent 10-fold to produce sufficient amounts of Vox2 to perform the in vivo studies.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, our group described the synthesis and characterization of (Et 3 NH) 2 [{VO(OH} 2 )(ox) 2 (µ–ox)] (Vox2, Figure 1 ), a centrosymmetric oxidovandadium(IV) binuclear complex containing the bioligand oxalate (ox 2− ) [ 48 ]. Treatment of human hepatocellular carcinoma (HepG2) cells with this complex in a hyperglycemic medium showed a similar or better response to the uptake of 2-NBDG (2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose), a fluorescent glucose analog, than with insulin at concentrations of vanadium below the toxicity threshold.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of human hepatocellular carcinoma (HepG2) cells with this complex in a hyperglycemic medium showed a similar or better response to the uptake of 2-NBDG (2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose), a fluorescent glucose analog, than with insulin at concentrations of vanadium below the toxicity threshold. Moreover, the previous stability studies in aqueous solutions have shown that the binuclear structure of Vox2 is maintained even at low concentrations, suggesting that this species could be promising for further anti-diabetic studies in vivo [ 48 ]. To achieve this, we used streptozotocin (STZ)-induced diabetic rats to evaluate the effect of Vox2 on glucose metabolism in the presence and absence of insulin and observed a remarkable reduction in blood glucose levels.…”

Section: Introductionmentioning

confidence: 99%

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A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Lopes,

Baptistella,

Nunes

et al. 2024

Pharmaceuticals

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Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3NH)2[{VO(OH}2)(ox)2(µ–ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days. Vox2 at 100 mg/kg in association with insulin caused a 3.4 times decrease in blood glucose in STZ rats (424 mg/dL), reaching concentrations similar to those in the normoglycemic animals (126 mg/dL). Compared to insulin alone, the association with Vox2 caused an additional decrease in blood glucose of 39% and 65% at 30 and 100 mg/kg, respectively, and an increased pancreatic GSH levels 2.5 times. Vox2 alone did not cause gastrointestinal discomfort, diarrhea, and hepatic or renal toxicity and was not associated with changes in blood glucose level, lipid profile, or kidney or liver function. Our results highlight the potential of Vox2 in association with insulin in treating diabetes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Lopes,

Baptistella,

Nunes

et al. 2024

Pharmaceuticals

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“…Uptake of fluorescently labelled glucose, 2-NBDG, by HepG2 cells was performed as described earlier. 39–41…”

Section: Methodsmentioning

confidence: 99%

Self-assembled di- and tripeptide gels for the passive entrapment and pH-responsive, sustained release of an antidiabetic drug, glimepiride

2022

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“…Taking into account the partial occupancy found for many of the water positions and the lack of efficient bonding, we can expect that they could be easily The crucial problem is the stability of such an open framework which is located between a classical covalently bonded 3D coordination MOF and a hydrogen-bonded organic framework (HOF), which relies on weak (mainly hydrogen bonds) interactions [46]. In the reported case, an additional moiety generates voids and we exploited oxalate ability for non-covalent interactions which were able to maintain the permanent porosity [47][48][49].…”

Section: Structure Descriptionmentioning

confidence: 99%

Sorption and Magnetic Properties of Oxalato-Based Trimetallic Open Framework Stabilized by Charge-Assisted Hydrogen Bonds

Muzioł

Tereba

Podgajny

et al. 2022

IJMS

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We report a new structure of {[Co(bpy)2(ox)][{Cu2(bpy)2(ox)}Fe(ox)3]}n·8.5nH2O NCU-1 presenting a rare ladder topology among oxalate-based coordination polymers with anionic chains composed of alternately arranged [Cu2(bpy)2(ox)]2+ and [Fe(ox)3]3- moieties. Along the a axis, they are separated by Co(III) units to give porous material with voids of 963.7 Å3 (16.9% of cell volume). The stability of this structure is assured by a network of stacking interactions and charge-assisted C-H…O hydrogen bonds formed between adjacent chains, adjacent cobalt(III) units, and alternately arranged cobalt(III) and chain motifs. The soaking experiment with acetonitrile and bromobenzene showed that water molecules (8.5 water molecules dispersed over 15 positions) are bonded tightly, despite partial occupancy. Water adsorption experiments are described by a D’arcy and Watt model being the sum of Langmuir and Dubinin–Serpinski isotherms. The amount of primary adsorption sites calculated from this model is equal 8.2 mol H2O/mol, being very close to the value obtained from the XRD experiments and indicates that water was adsorbed mainly on the primary sites. The antiferromagnetic properties could be only approximately described with the simple CuII-ox-CuII dimer using H = −J×S1×S2, thus, considering non-trivial topology of the whole Cu-Fe chain, we developed our own general approach, based on the semiclassical model (SC) and molecular field (MF) model, to describe precisely the magnetic superexchange interactions in NCU-1. We established that Cu(II)-Cu(II) coupling dominates over multiple Cu(II)-Fe(III) interactions, with JCuCu = −275(29) and JCuFe = −3.8(1.6) cm−1 and discussed the obtained values against the literature data.

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An oxalate-bridged oxidovanadium(IV) binuclear complex that improves the in vitro cell uptake of a fluorescent glucose analog

Cited by 6 publications

References 65 publications

A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Self-assembled di- and tripeptide gels for the passive entrapment and pH-responsive, sustained release of an antidiabetic drug, glimepiride

Sorption and Magnetic Properties of Oxalato-Based Trimetallic Open Framework Stabilized by Charge-Assisted Hydrogen Bonds

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