Birth weight and cognition in children with epilepsy

Jackson, Daren C.; Lin, Jack J.; Chambers, Karlee L.; Kessler-Jones, Alanna; Jones, Jana E.; Hsu, David; Stafstrom, Carl E.; Seidenberg, Michael; Hermann, Bruce P.

doi:10.1111/epi.12622

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…Also, a measure of executive function (D-KEFS Category Switching) presented a high integration to those tests of intelligence only in the group of controls. As has been demonstrated previously, epilepsy appears to disrupt a number of robust relationships observed in controls (e.g., birth weight and cognition [ 37 ], maternal IQ and child IQ [ 38 ]) that are absent in children with epilepsy.…”

Section: Discussionmentioning

confidence: 95%

Developmental Reorganization of the Cognitive Network in Pediatric Epilepsy

et al. 2015

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Traditional approaches to understanding cognition in children with epilepsy (CWE) involve cross-sectional or prospective examination of diverse test measures, an approach that does not inform the interrelationship between different abilities or how interrelationships evolve prospectively. Here we utilize graph theory techniques to interrogate the development of cognitive landmarks in CWE and healthy controls (HC) using the two-year percentage change across 20 tests. Additionally, we characterize the development of cognition using traditional analyses, showing that CWE perform worse at baseline, develop in parallel with HC, statically maintaining cognitive differences two years later. Graph analyses, however, showed CWE to exhibit both lower integration and segregation in development of their cognitive networks compared to HC. In conclusion, graph analyses of neuropsychological data capture a dynamic and changing complexity in the interrelationships among diverse cognitive skills, maturation of the cognitive network over time, and the nature of differences between normally developing children and CWE.

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Section: Discussionmentioning

confidence: 95%

Developmental Reorganization of the Cognitive Network in Pediatric Epilepsy

et al. 2015

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“…Low birth weight, an important indicator of prenatal environment, has been associated with differential risk for neonatal mortality [29,30], neurodevelopment and behavioral problems [31,32], and other diseases [33,34].…”

Section: Birth Weightmentioning

confidence: 99%

Effects of Prenatal Methamphetamine Exposure on Birth Outcomes, Brain Structure, and Neurodevelopmental Outcomes

et al. 2021

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This study reviews the findings from previous research on the effects of prenatal methamphetamine (MA) exposure on birth outcomes, brain structure, and neurodevelopmental outcomes of the offspring. These findings indicate that prenatal MA exposure may lead to shorter gestational age, lower birth weight, lower head circumference, and shorter body length of neonatal, structural brain changes, and impairment in cognitive development, motor development, inhibitory control, and attention of children from 1 to 15 years. Based on these findings of the previous cohort studies on the effect of prenatal MA exposure on the birth outcomes and childhood outcomes of the offspring, we conclude by discussing the shortcomings and inconsistencies of previous studies in each section. A multicenter, large-scale population-based prospective cohort study is needed to establish and seek the differences and similarities of the pathological changes in different systems among offspring prenatally exposed to MA in different periods. And the pathophysiology mechanism underlying these changes should be studied by the method of omics technology in future. These efforts are of great significance to address the adverse health outcomes caused by prenatal MA exposure.

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“…Birth weight, a factor often influenced by gestational age, has been found to be lower in patients with epilepsy compared to healthy controls ( 10 ). The effect of sex on the development of childhood epilepsy has been controversial.…”

Section: Introductionmentioning

confidence: 99%

Impact of prenatal life on the risk of developing epilepsy

Otinashvili,

Ahmadi,

Iordanishvili

et al. 2024

Med Int

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Epilepsy is an enduring predisposition of the brain to generate epileptic seizures and has a worldwide incidence of 21-24 per 100,000 cases among children. Epilepsy is a multifactorial disease; however, certain risk factors are predicted to increase its incidence. Abnormal brain development during prenatal life, particularly during the last trimester, is considered to play a crucial role in the development of certain neurological disorders. The present study evaluated a total of 453 children between the ages of 1 to 18 years, with or without epilepsy. The association between gestational age, birth weight, maternal age and sex, and the risk of developing epilepsy was examined in the children. It was found that children born preterm had a 2.3-fold higher risk of having epilepsy [odds ratio (OR), 2.3; 95% confidence interval (CI), 1.4-3.7], and those whose birth weight was <2,500 g had a 2-fold greater risk of developing epilepsy (OR, 2; 95% CI, 1.1-3.6). The male sex appeared to be associated with a lower risk of developing epilepsy and there was a statistically significant association between the female sex and the risk of developing epilepsy only in preterm children (OR, 3.2; 95% CI, 1.2-8.8). Maternal age was not found to be associated with the risk of developing epilepsy. On the whole, the present study demonstrates that a short gestational age, a low birth weight and the female sex are associated with an increased risk of developing epilepsy.

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Birth weight and cognition in children with epilepsy

Cited by 10 publications

References 40 publications

Developmental Reorganization of the Cognitive Network in Pediatric Epilepsy

Developmental Reorganization of the Cognitive Network in Pediatric Epilepsy

Effects of Prenatal Methamphetamine Exposure on Birth Outcomes, Brain Structure, and Neurodevelopmental Outcomes

Impact of prenatal life on the risk of developing epilepsy

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