Effects of Prenatal Methamphetamine Exposure on Birth Outcomes, Brain Structure, and Neurodevelopmental Outcomes

Zhang, Youyou; Gong, Fuhua; Liu, Pan; He, Yongqing; Wang, Hui

doi:10.1159/000517753

Cited by 8 publications

(5 citation statements)

References 64 publications

(103 reference statements)

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“…10 ). Other researchers have found that infants prenatally exposed to methamphetamine tended to show a significantly smaller head circumference at birth or 1 year, [ 54 , 62 , 72 , 73 ] supporting our findings.…”

Section: Discussionsupporting

confidence: 91%

The tragedy of smoking, alcohol, and multiple substance use during pregnancy

et al. 2022

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Background. Antenatal substance use is a significant public health concern in South Africa (SA). Information on smoking, drinking and drug use during pregnancy was collected prospectively for the Safe Passage Study of the PASS (Prenatal Alcohol in Sudden infant death syndrome and Stillbirth) Network.Objectives. Data from 4 926 pregnant women in a community near Tygerberg Academic Hospital, Cape Town, were examined to determine whether associations between different substance use groups and postnatal infant outcomes at birth and 1 year were significant.Methods. Gestational age (GA) was determined by earliest ultrasound. Maternal data were collected at enrolment or first antenatal visit. Substance use data were obtained at up to four occasions. Birthweight data were derived from medical records, and birthweight z-scores (BWZs) were specifically calculated using INTERGROWTH-21st study data. Statistical analyses were done with Statistica version 13. Results. Women who used more substances enrolled later, were younger, and had smaller mid-upper arm circumferences (MUACs), less education and lower monthly income than women who used no substances (control group). Infants born to women who used more substances had lower GA at delivery, birthweight and BWZ than infants from the control group. At 1 year, infants born to women who used more substances had a lower weight, shorter length and smaller head circumference. Education was positively associated with all infant outcomes at birth and 1 year. MUAC was positively associated with infant BWZ, and weight and length at 1 year. Income was negatively associated with BWZ, but positively associated with all 1-year outcomes.Conclusion. Substance use during pregnancy affects infant outcomes at birth and 1 year of age. The addictive properties of substance use make cessation difficult, so prevention strategies should be implemented long before pregnancy. Higher maternal education, associated with better infant outcomes at birth and 1 year and acting as a countermeasure to substance use, is of paramount importance.

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Section: Discussionsupporting

confidence: 91%

The tragedy of smoking, alcohol, and multiple substance use during pregnancy

et al. 2022

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“…The smallest head circumferences were in the MetDrink group, despite adjustment for prematurity (Figure 10). Other researchers have found that infants prenatally exposed to methamphetamine tended to show a significantly smaller head circumference at birth or 1 year [54,62,72,73], supporting our findings.…”

Section: One-year Outcomes and Trendssupporting

confidence: 91%

The Tragedy of Smoking, Alcohol, and Multiple Substance use during Pregnancy

2023

ARCH Women Health Care

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Background: Antenatal substance use is a significant public health concern in South Africa. Information on smoking, drinking and drug use during pregnancy was collected prospectively for the Safe Passage Study of the Prenatal Alcohol in Sudden infant death syndrome and Stillbirth Network.Objectives: Data from 4 926 pregnant women in a local community near Tygerberg Academic Hospital, were examined to determine whether associations between different substance use groups and postnatal infant outcomes at birth and 1 year were significant.Methods: Gestational age (GA) was determined by earliest ultrasound. Maternal data were collected at enrolment or first antenatal visit. Substance use data were obtained at up to four occasions. Birthweight data were derived from medical records, and birthweight z-scores (BWZs) were specifically calculated using INTERGROWTH-21st study data. Statistical analyses were done with Statistica version 13.Results: Women who used more substances enrolled later, were younger, and had smaller mid-upper arm circumferences (MUACs), less education and lower monthly income than women who used no substances (control group). Infants born to women who used more substances had lower GA at delivery, birthweight and BWZ than infants from the control group. At 1 year, infants born to women who used more substances had a lower weight, shorter length and smaller head circumference. Education was positively associated with all infant outcomes at birth and 1 year. MUAC was positively associated with infant BWZ, and weight and length at 1 year. Income was negatively associated with BWZ, but positively associated with all 1-year outcomes. Conclusion:Substance use during pregnancy affects infant outcomes at birth and 1 year of age. The addictive properties of substance use make cessation difficult, so prevention strategies should be implemented long before pregnancy. Higher maternal education, associated with better infant outcomes at birth and 1 year and acting as a countermeasure to substance use, is of paramount importance.

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“…There is some clinical evidence that PME is associated with increased anxious/depressed problems and emotional reactivity (LaGasse et al, 2012), as well as aggressive behaviors (Eze et al, 2016) and cognitive defects (Sanjari Moghaddam et al, 2021). In children, cognitive sequelae of PME include broad deficits in the domains of attention, learning, memory, and visual‐motor integration (Kwiatkowski et al, 2018; Roos et al, 2020; Sanjari Moghaddam et al, 2021; Schreiter et al, 2019; Zhang et al, 2021), associated with smaller subcortical volumes, especially in the hippocampus (Chang et al, 2004; Kwiatkowski et al, 2018; Warton et al, 2018). At age 14, children with PME showed problems with advancement in school due to learning delays in mathematics and language (Cernerud et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal methamphetamine exposure on spatial cognition and hippocampal synaptic plasticity in adolescent rats

Aghazadeh

Roshan‐Milani

Drafshpour

et al. 2022

Intl J of Devlp Neuroscience

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Global rise in methamphetamine (MA) abuse during pregnancy has placed a large number of children at risk for the adverse consequences of prenatal methamphetamine exposure (PME). While behavioral and neurocognitive deficits of PME have been extensively studied in humans and adult rodents, far less is known regarding the sex-and dose-dependent effects of PME as well as the underlying mechanisms. Adolescence in nonhuman primates is also a less explored territory. In the present study, PME was inducted by oral treatment to pregnant rats on gestational days 15-19 with either low dose (0.1 mg/ml) or high dose (0.6 mg/ml) of MA. The cognitive effects of PME were then evaluated in two adolescence age-intervals: early adolescent (started on postnatal day [PND] 21) and mid-adolescent (started on PND 33), among male and female rat offspring using Morris water maze (MWM) test. Alterations in hippocampal synaptic plasticity in Schaffer collaterals-CA1 pathway were also measured in vitro. Results of behavioral test showed that PME led to serious deficits of learning and memory abilities in both male and female rat offspring. PME also depressed LTP in most of the PME subgroups. Moreover, 21-day-old rats were more sensitive to PME-induced cognitive impairment in MWM tasks, but not in hippocampal synaptic plasticity, than 33-day-old rats. No sexdependent effects of PME were found on the cognitive function and synaptic plasticity. These findings confirmed that PME impacted negatively on cognitive performance in prepubertal male and female rats, and the impairment of hippocampal synaptic functions might partly play a significant role in these effects.

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Effects of Prenatal Methamphetamine Exposure on Birth Outcomes, Brain Structure, and Neurodevelopmental Outcomes

Cited by 8 publications

References 64 publications

The tragedy of smoking, alcohol, and multiple substance use during pregnancy

The tragedy of smoking, alcohol, and multiple substance use during pregnancy

The Tragedy of Smoking, Alcohol, and Multiple Substance use during Pregnancy

Effects of prenatal methamphetamine exposure on spatial cognition and hippocampal synaptic plasticity in adolescent rats

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