Scrum of hypercholesterolemic rabbits, when pulsated for 72 hours at pressures of 300 mm. Hg/0 mm. Hg with a pulse rate of 80 produced a birefringent deposit in excised pieces of rabbit aortae. Scrum from normal rabbits did not produce this deposit. The active component or components responsible for this deposit are in the |8-lipoprotein fraction of serum. The birefringent material is detectable in serum by this method before lipoid degeneration of the arterial intima becomes apparent in the sacrificed animal…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.