Experimental Atherosclerosis

Kritchevsky, David

doi:10.1016/b978-0-12-544952-6.50007-1

Cited by 25 publications

(5 citation statements)

References 369 publications

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“…The ratio of glycine: taurine conjugation (G/T) of bile acids in the bile of animals resistant or susceptible to experimentally induced atherosclerosis has recently been reviewed (Kritchevsky, 1964). In normal man, G/T is normally 3:1, rises in hypothyroidism and falls to normal upon administration of thyroid drugs (Hellslrom and Sjovall, 1961).…”

Section: Result; S An (I Discussionmentioning

confidence: 99%

Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Kritchevsky¹,

Kritchevsky²,

Nair³

et al. 1967

Ann Nutr Metab

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Section: Result; S An (I Discussionmentioning

confidence: 99%

Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Kritchevsky¹,

Kritchevsky²,

Nair³

et al. 1967

Ann Nutr Metab

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“…In 1958, Lambert et al (15) reported that saturated fat alone was atherogenic for rabbits. Our own experience with saturated fat (16,17) had shown no such effect. Collation of the available literature (18) revealed that when added to ordinary rabbit ration, saturated fat did not affect either serum lipids or atherosclerosis but when added to a semipurified diet, saturated fat was hyper ~-lipoproteinemic, hyperlipemic, and atherogenic.…”

mentioning

confidence: 78%

Diet and cholesteremia

Kritchevsky

1977

Lipids

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The statistical correlation between elevated serum cholesterol levels and increased risk of coronary heart disease has channeled thinking towards regarding dietary fat and cholesterol as the principal causes of hypercholesteremia. Since 1909 there have been a number of changes in nutrient availability in the United States. Protein availability is unchanged but the ratio of animal to vegetable protein rose from 1.06 in 1909 to 2.37 in 1972. Fat availability has risen by 26% with the ratio of animal to vegetable fat falling from 4.88 in 1909 to 1.64 in 1972. A review of available data indicates that amount and type of protein may affect cholesteremia and atherosclerosis in experimental animals. Soy protein is less cholesteremic than casein but the extent of difference can be affected by the type of carbohydrate. In a semipurified, cholesterol-free diet, saturated fat exerts an atherogenic effect but unsaturated fat does not. No atherogenicity is evident when saturated fat is added to laboratory ration. In the semipurified diet, fructose is more atherogenic than glucose, and casein is more atherogenic then soy protein. The latter difference can be virtually eliminated if alfalfa replaces cellulose as the dietary fiber. The data suggest that all elements of the diet interact and can affect cholesteremia and atherosclerosis. These effects must be considered in the planning of dietary intervention trials.

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“…XX, June 1967 atherogenic substance. The amount of fat fed was 44.8% of the total calories, a greater amount than has usually been used in animal experiments of the same character (6).…”

Section: Discussionmentioning

confidence: 99%

“…Accepted for publication April 15, 1967. saturated fat produces atherosclerosis is not conclusive (6,7). In some instances, the feeding of semisynthetic diets containing saturated fat has induced hypercholesterolemia and atherosclerosis, but the experimental animals generally failed to grow, became unhealthy, and may have suffered from some dietary deficiency (8)(9)(10)(11).…”

Section: Additional Abstractmentioning

confidence: 99%

Relative Failure of Saturated Fat in the Diet to Produce Atherosclerosis in the Rabbit

Connor

Rohwedder

Armstrong

1967

Circulation Research

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Three "saturated" fats of vegetable origin were fed to different groups of rabbits for periods up to 1 year. Cocoa butter and a hydrogenated vegetable oil shortening produced no hypercholesterolemia. Coconut oil feeding increased the serum cholesterol concentrations for 4 months, but a decline to baseline values occurred after 6 months. No gross atherosclerosis occurred in any animal fed coconut oil or the hydrogenated vegetable oil shortening. Slight atherosclerotic lesions were found in 50% of the rabbits fed cocoa butter. Aortic cholesterol content was slightly increased in animals fed coconut oil and cocoa butter. Dietary fats, even when highly saturated, had only a minimal capacity to produce atherosclerosis in the rabbit, a species usually highly susceptible to the induction of atherosclerosis. When a moderate amount of cholesterol was added to the diet, the serum cholesterol levels increased greatly and considerable atherosclerosis resulted.

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Experimental Atherosclerosis

Cited by 25 publications

References 369 publications

Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Diet and cholesteremia

Relative Failure of Saturated Fat in the Diet to Produce Atherosclerosis in the Rabbit

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