Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Kritchevsky, David; Kritchevsky, Evelyn S.; Nair, Padmanabhan P.; Jastremsky, Judith A.; Shapiro, Irwin L.

doi:10.1159/000175198

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Other agents used in the past and currently in use include D-thyroxine, which is thought to act by increasing the catabolism of cholesterol to bile acids (Kritchevsky, 1960), and nicotinic acid, which inhibits the mobilization of free fatty acids from adipose tissue (Carlson & Oro, 1962). Finally, there are the bile acid-sequestering resins, such as cholestyramine, Colestipol and DEAE-Sephadex.…”

Section: Surrey Kt20 Int Ukmentioning

confidence: 99%

Hypolipidaemic Agents: Current Status and Recent Developments

Morgan¹

1976

Biochemical Society Transactions

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Section: Surrey Kt20 Int Ukmentioning

confidence: 99%

Hypolipidaemic Agents: Current Status and Recent Developments

Morgan¹

1976

Biochemical Society Transactions

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“…Many investigations have demonstrated the acceleration of lipid synthesis by the action of thyroxine or triiodothyronine. The rate of synthesis of cholesterol is increased in man and in rats receiving thyroid hormones [347,459], making the hypocholesteremia observed in thyrotoxicosis difficult to explain. However, simultaneous stimulation of the conversion of cholesterol into bile acids [158] and the elimination of cholesterol from the body [505] provide an explanation for this observation.…”

Section: Metabolismmentioning

confidence: 99%

Physiological Effects of the Thyroid Hormones

et al. 1975

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The thyroid gland has a powerful influence over the activities of the whole body. If the function of the gland is for any reason lost, serious disturbances of chemical and morphological structure arise and are manifested as physical and mental disorders. The diversity of the action of thyroid hormones on physiological functions, on the metabolic rate, and on the activity of various enzyme systems both in the body as a whole and in tissue preparations has been known for a long time. Our knowledge of the role of thyroid hormones is based on experiments in which a particular thyroid hormone has been given to healthy and athyrotic animals and on extensive clinical observations on patients with hyperthyroid and hypothyroid states.The effect of thyroid hormones in vivo is expressed as reactions of whole organs and of individual physiological functions and morphological structures. The internal secretions of the thyroid gland modify growth and metamorphosis, the utilization of oxygen by the body as a whole or by tissue preparations in vitro, various aspects of metabolism, and the activity of particular enzyme systems.The extreme diversity of the effects observed after injection of thyroid hormone may reflect the primary action of this agent on a single link fundamental to the mechanism of biochemical processes in the cell or on a single morphological structure responsible for the proper integration of processes at the cell level. These problems will be examined fully later. Here I shall merely state that when the action of a thyroid hormone is discussed, the term is used not only with respect to the thyroxine and triiodothyronine produced in the thyroid gland, but also to several of their derivatives and analogs. However, we know that all compounds with the biological activity 125 Y. K. Turakulov et al., Thyroid Hormones

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Effect of Free Fatty Acids on Cholesterol Metabolism in the Baboon

Cited by 2 publications

References 5 publications

Hypolipidaemic Agents: Current Status and Recent Developments

Hypolipidaemic Agents: Current Status and Recent Developments

Physiological Effects of the Thyroid Hormones

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