Birdshot retinochoroiditis: long term follow-up of a chronically progressive disease

Uveitic macular edema

“…Moreover, the intermittent treatment of inflammatory exacerbations has not been shown to prevent the progressive visual loss. 34,35 However, these topical treatments are mainly used in cases of unilateral uveitis, or when the use of systemic corticosteroids is contraindicated, and they can also be used occasionally in association with a systemic treatment ( Figure 9). In cases of sight-threatening chronic bilateral posterior uveitis, the systemic route is often necessary and steroids are the standard first-line treatment.…”

Daclizumab for Treatment of Birdshot Chorioretinopathy

“…29,31 Patients treated with steroids alone show progressive ERG decline. 10 Serial visual field tests are another potentially useful ancillary test for following up BSCR. 34 However, we did not perform serial visual field tests as part of this study.…”

“…[6][7][8][9] The natural history of BSCR is one of progressive retinal dysfunction leading to poor vision. 10,11 Intermittent treatment of inflammatory exacerbations does not meaningfully impact this adverse natural history. 10,11 For this reason, prolonged systemic immunomodulatory therapy (IMT) has been recommended and has shown promise for preservation of retinal function and vision.…”

“…10,11 Intermittent treatment of inflammatory exacerbations does not meaningfully impact this adverse natural history. 10,11 For this reason, prolonged systemic immunomodulatory therapy (IMT) has been recommended and has shown promise for preservation of retinal function and vision. [12][13][14] However, some patients continue to lose retinal function despite treatment with traditional IMT agents, such as cyclosporine and mycophenolate mofetil.…”

Visual Acuity in Birdshot Retinochoroidopathy Evaluation

“…Although BRC is a potentially blinding pathology, evolution towards retinal atrophy and blindness occurs in a subclinical fashion [5][6][7]. As a consequence, disease evaluation and monitoring should not be neglected and must be as complete and objective as possible, including both clinical and ancillary tests.…”