Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up

Alshawaf, Eman; Al-Ozairi, Ebaa; Al-Asfar, Fahad; Al-Beloushi, Shaima; Kumari, Surbhi; Tuomilehto, Jaakko; Arefanian, Hossein

doi:10.1016/j.soard.2018.05.026

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…Post-LSG participants displayed a rapid improvement in various clinical parameters. LSG ameliorated FPG, A1C, c-peptide, insulin resistance (iHOMA-IR), and β-cell activity (iHOMA2% β), indicating T2D remission (previously reported [20]). There was a gradual decline in weight loss post-LSG that was reflected by BMI, excess weight loss (%EWL), and body fat (%BF) in people with morbid obesity, with and without T2D, which was significant after one year of LSG [20].…”

Section: Lsg Reduces the Risk Of Cvd And Improvessupporting

confidence: 66%

“…LSG ameliorated FPG, A1C, c-peptide, insulin resistance (iHOMA-IR), and β-cell activity (iHOMA2% β), indicating T2D remission (previously reported [20]). There was a gradual decline in weight loss post-LSG that was reflected by BMI, excess weight loss (%EWL), and body fat (%BF) in people with morbid obesity, with and without T2D, which was significant after one year of LSG [20]. Lipid metabolism improved significantly post-LSG, and VLDL levels dropped significantly after 6 months (0:48 ± 0:07 mM, n = 10, p < 0:05) and 1 year (0:39 ± 0:06 mM, n = 10, p < 0:01) of surgery in people with morbid obesity and T2D.…”

Section: Lsg Reduces the Risk Of Cvd And Improvessupporting

confidence: 66%

“…The group with morbid obesity included people with T2D ( n = 17, mean age 39 ± 2.5 years), and people without T2D ( n = 23, mean age 32 ± 2.6 years). As described previously [ 20 ], from participants who underwent LSG, only 11 with T2D and 17 without T2D were followed up for one year after surgery (i.e., after 6 months and 1 year). The control groups included normal-weight participants that were not exposed to the surgical intervention.…”

Section: Methodsmentioning

confidence: 99%

“…As described [ 20 ], body measurements including weight, height, hip, and waist circumference were taken by a trained nurse. Blood pressure (BP) values are the average of three consecutive measurements.…”

Section: Methodsmentioning

confidence: 99%

“…Statistical Analysis. Statistical analysis was performed as previously described [20]. Briefly, normal distribution was tested using the Shapiro-Wilk normality test.…”

Section: Anthropometric and Biochemical Measurementsmentioning

confidence: 99%

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Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

Alshawaf

Al-Ozairi

Al-Asfar

et al. 2020

Journal of Diabetes Research

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Predictive indices like the atherogenic index of plasma (AIP) have been developed to estimate the risk of cardiovascular disease (CVD). Metabolic surgery is the most effective treatment for a rapid improvement of morbid obesity and its comorbidities such as type 2 diabetes (T2D) and CVD. A decreased reoccurrence of CVD after metabolic surgery has been reported by several studies. However, studies utilizing predictive indices for CVD risk in CVD-free morbid-obese patients who undertook laparoscopic sleeve gastrectomy (LSG) are lacking. Here, we use AIP as a tool to evaluate the improvement in CVD risk post-LSG in morbid-obese people who had no history of CVD. Method. We compared baseline, 6- and 12-month post-LSG score of AIP, vascular age, circulating biochemical markers related to CVD in two groups of BMI and age-matched morbid-obese participants with and without T2D. Results. At baseline, people with T2D had significantly higher AIP both, with morbid obesity (0.23±0.06, p<0.001) and normal weight (0.022±0.05, p<0.001) compared to their BMI-matched without T2D group. People with morbid obesity had low AIP (−0.083±0.06). Vascular age was significantly higher in people with morbid obesity and T2D (65.8±3.7year, p<0.0001) compared to morbid obesity (37.9±2.6 year). After one year, AIP was significantly reduced compared to baseline score in people with morbid obesity with/without T2D, respectively (−0.135±0.07, p=0.003; and −0.36±0.04, p=0.0002). Conclusion. Our data illuminates AIP as a reliable predictive index for CVD risk in morbid-obese people who had no history of CVD. Moreover, AIP accurately distinguishes between morbid obesity with T2D and morbid obesity and showed a rapid and significant reduction in CVD risk after LSG in people who had no history of CVD. This is a ClinicalTrials.gov registered trial (Reference NCT03038373).

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Section: Lsg Reduces the Risk Of Cvd And Improvessupporting

confidence: 66%

Section: Lsg Reduces the Risk Of Cvd And Improvessupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Statistical Analysis. Statistical analysis was performed as previously described [20]. Briefly, normal distribution was tested using the Shapiro-Wilk normality test.…”

Section: Anthropometric and Biochemical Measurementsmentioning

confidence: 99%

See 3 more Smart Citations

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

Alshawaf

Al-Ozairi

Al-Asfar

et al. 2020

Journal of Diabetes Research

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Positive correlation of ANGPTL8 expression in human visceral adipose tissue with body mass index

Chen,

Huang,

Lee

et al. 2024

Journal of the Formosan Medical Association

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Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4

Bini¹,

D’Erasmo²,

Astiarraga³

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up

Abstract: Elevated baseline ANGPTL8 in participants with diabetes at baseline reflected a link to T2D. Interestingly, the unique biphasic pattern of change in fasting ANGPTL8 post-LSG, occurred only in people with diabetes, suggesting ANGPTL8's potential role in T2D remission.

Cited by 9 publications

References 35 publications

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

Positive correlation of ANGPTL8 expression in human visceral adipose tissue with body mass index

Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4

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