Biphasic calcium phosphate–casein bone graft fortified with Cassia occidentalis for bone tissue engineering and regeneration

Abstract

Research on traditional herbs is gaining momentum owing to their potent medical properties, among which Cassia occidentalis (CO) is a promising herb, with osteogenic potential. The study investigates the efficacy of CO extract incorporated biphasic calcium phosphate as an osteoinductive material. Prepared bone implants were characterized physico-chemically using FT-IR, TGA, XRD, SEM and EDX. The implants were analysed further for mechanical and biological properties. The results revealed that CO extract-incorporated bone implants possessed better compression strength and it was able to induce proliferation and enhance alkaline phosphatase activity in SaOS-2 cells. The implant proves to be promising for bone tissue engineering, and hence it demands further in vivo evaluation.

Co-Deposition of a Hydrogel/Calcium Phosphate Hybrid Layer on 3D Printed Poly(Lactic Acid) Scaffolds via Dip Coating: Towards Automated Biomaterials Fabrication

“…Weak bands at 1444 and 870 cm −1 (ν 3 PO 4 3− ) are characteristic for carbonate ions. A sharp double band at 1038 and 1022 cm −1 (ν 4 PO 4 3− ) and a sharp triple band at 602, 559, and 528 cm −1 are due to phosphate and hydrogen phosphate ions [ 20 , 21 ].…”

Viscoelasticity, mechanical properties, and in vitro biodegradation of injectable chitosan-poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/nanohydroxyapatite composite hydrogel

“…It was reported in previous studies that the incorporation of bioceramics can significantly improve mineralization and cell activities on polymeric hydrogels, showing osteoinductivity and/or osteoconductivity for bone regeneration applications [17,18]. Among the available bioceramics, nHA particles have received great attention in bone regeneration due to its excellent bioactivity, biocompatibility and potential osteogenic effect [19,20].…”

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

“…The extract of G. glabra has been used in the treatment of low bone mass, osteoporosis, fractures, bone defects, osteomalacia, osteogenesis imperfecta, bone disease, and periodontal diseases (Kumar et al, ). Rajesh () described the inhibitory effect on bone reabsorption of G. glabra , whereas Choi () reported that glabridin is responsible for this activity.…”