Co-Deposition of a Hydrogel/Calcium Phosphate Hybrid Layer on 3D Printed Poly(Lactic Acid) Scaffolds via Dip Coating: Towards Automated Biomaterials Fabrication

Schneider, Mat­thias; Günter, Christina; Taubert, Andreas

doi:10.3390/polym10030275

Cited by 29 publications

(22 citation statements)

References 32 publications

(51 reference statements)

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“…Furthermore, the CP layer was not mechanically stable and could be dispersed. However, the presence of gelatin and or a chitosan coating on the surface significantly increased the adhesion of the CP layer onto the PLA scaffolds [146]. Prior to surface coating and mineralization, the 3D printed PLA scaffolds were hydrolyzed with NaOH to form hydroxyl and carboxyl groups on the PLA surface; then the surface was modified with 3-aminopropyltriethoxysilane (APTES).…”

Section: The Use Of Other Materials For the Surface Modification Of 3mentioning

confidence: 99%

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Surface Modification of 3D Printed PLA Objects by Fused Deposition Modeling: A Review

Baran

Erbil

2019

Colloids and Interfaces

148

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Polylactic acid (PLA) filaments are very popular as a thermoplastic source used in the 3D printing field by the “Fused Deposition Modeling” method in the last decade. The PLA market is expected to reach 5.2 billion US dollars in 2020 for all of its industrial uses. On the other hand, 3D printing is an expanding technology that has a large economic potential in many industries where PLA is one of the main choices as the source polymer due to its ease of printing, environmentally friendly nature, glossiness and multicolor appearance properties. In this review, we first reported the chemical structure, production methods, general properties, and present market of the PLA. Then, the chemical modification possibilities of PLA and its use in 3D printers, present drawbacks, and the surface modification methods of PLA polymers in many different fields were discussed. Specifically, the 3D printing method where the PLA filaments are used in the extrusion-based 3D printing technologies is reviewed in this article. Many methods have been proposed for the permanent surface modifications of the PLA where covalent attachments were formed such as alkaline surface hydrolysis, atom transfer polymerization, photografting by UV light, plasma treatment, and chemical reactions after plasma treatment. Some of these methods can be applied for surface modifications of PLA objects obtained by 3D printing for better performance in biomedical uses and other fields. Some recent publications reporting the surface modification of 3D printed PLA objects were also discussed.

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Section: The Use Of Other Materials For the Surface Modification Of 3mentioning

confidence: 99%

“…NaOH treatment cut the PLA ester bonds, producing hydroxyl and carboxylic acid groups on the surface but also caused an increase in the roughness, leading to higher contact angles than expected. The subsequent mineralization made the 3D printed scaffold biocompatible [146].…”

Section: The Use Of Other Materials For the Surface Modification Of 3mentioning

confidence: 99%

Surface Modification of 3D Printed PLA Objects by Fused Deposition Modeling: A Review

Baran

Erbil

2019

Colloids and Interfaces

148

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“…We have previously shown that calcium phosphate (CP), an important biomaterial [22][23][24], does not adhere to freshly printed PLA scaffolds. Consequently, the development of stable, CP-coated 3D printed PLA biomaterials is rather challenging [25][26][27]. This is unfortunate because PLA/CP composites would be prime candidates for implant materials with favorable properties.…”

Section: Introductionmentioning

confidence: 99%

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

et al. 2020

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The article describes a systematic investigation of the effects of an aqueous NaOH treatment of 3D printed poly(lactic acid) (PLA) scaffolds for surface activation. The PLA surface undergoes several morphology changes and after an initial surface roughening, the surface becomes smoother again before the material dissolves. Erosion rates and surface morphologies can be controlled by the treatment. At the same time, the bulk mechanical properties of the treated materials remain unaltered. This indicates that NaOH treatment of 3D printed PLA scaffolds is a simple, yet viable strategy for surface activation without compromising the mechanical stability of PLA scaffolds.

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“…Hydrogel/calcium phosphate hybrid layer [145] Significant contact angle increase Chitosan add a certain anti-infection property, gelatin is attractive for bone ingrowth Simplicity, adaptability and versatility Polydopamine/gelatin/nano HA and ponericin G1 [146] Completely hydrophilic and stronger affinity for serum…”

Section: Coating Physical Property Change Results Advantagementioning

confidence: 99%

“…[151] Nowadays, scaffold formation is typically made from materials selected by stacking struts on top of each other to achieve the final 3D object. [143,145,147,148] Many of the parameters associated with these struts and resulting meshes can vary, such as the diameter of the struts, the space between them, and the orientation from one layer to another. The macroscopic morphology of the PLA surface can even affect the orientation and morphology of the cells: the grooves of the wavy scaffold significantly induce cell elongation and change the morphology of the nucleus, whereas the cells grown on the porous scaffold are flatter and curved.…”

Section: Support For Induction Of Angiogenesismentioning

confidence: 99%

Recent Progress on 3D‐Printed Polylactic Acid and Its Applications in Bone Repair

Chen

Wang

et al. 2019

Adv Eng Mater

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3D printing is an additive manufacturing (AM) technology that has developed rapidly in the past decades due to its advantages, such as freedom of design, mass customization, waste minimization, and the ability to manufacture complex structures, as well as fast prototyping. Various materials are used in 3D printing, including metals, polymers, ceramics, concrete, and their composites. The polymer's easy processing makes it stands out among many materials. As a thermoplastic polymer, polylactic acid (PLA) received more attention as an effective biomedical material due to its proven biodegradation and biocompatibility. Herein, the development of 3D-printing technology is summarized and various applications of 3D-printed PLA and their composites in orthopedics are introduced. Furthermore, the current limitations and future opportunities in 3D printing are also discussed to help guide the 3D-printing development and improve 3D-printing strategies in orthopedic.

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Co-Deposition of a Hydrogel/Calcium Phosphate Hybrid Layer on 3D Printed Poly(Lactic Acid) Scaffolds via Dip Coating: Towards Automated Biomaterials Fabrication

Cited by 29 publications

References 32 publications

Surface Modification of 3D Printed PLA Objects by Fused Deposition Modeling: A Review

Surface Modification of 3D Printed PLA Objects by Fused Deposition Modeling: A Review

Surface Etching of 3D Printed Poly(lactic acid) with NaOH: A Systematic Approach

Recent Progress on 3D‐Printed Polylactic Acid and Its Applications in Bone Repair

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