Biperiden-induced delirium model in rats: A behavioral and electroencephalographic study

Abstract

出版社

Biperiden-Induced Delirium in an Adolescent Patient

“…In an animal model, biperidentreated rats showed manifestations of delirium similar to humans with regard to changes in behavior and electroencephalographic recordings. These changes were observed only at high doses of biperiden, at 40 mg/kg, but not at lower doses, 0.4 and 4.0 mg/kg (Tamura et al 2006). Such results suggest that the development of delirium was associated with the dose of biperiden administered.…”

Biperiden for treatment of somnambulism in adolescents and adults with or without epilepsy: Clinical observations

“…Although biperiden has been implicated in the development of delirium in a rat model [16], we have no reports of delirium in our patients. In addition, it may be of interest that biperiden seemed to worsen the course of REM behavioral disorder, at least in one patient we treated and reported here.…”

“…Montagna et al [21] attempted to explain the anatomic and neurochemical bases of this theory postulating ACh as a possible common pathogenetic mechanism. Inhibition of mesopontine cholinergic neurons by administration of the muscarinic antagonist biperiden could possibly induce EEG slowing and reduce arousal level [16]. The components of the ascending activating reticular system which take part in the sleep-wake switch model include dopamine-containing neurons in the substantia nigra and the ventral tegmental area and cholinergic neurons of the basal forebrain and the pedunculopontine and laterodorsal tegmenti [22].…”

Biperiden kullanımıyla ilişkili deliryum tablosu; Olgu sunumu

“…Biperiden ve benzeri antikolinerjik ilaçlar beyinde kolinerjik yolağı inhibe ederek deliryuma yol açarlar. Bir deneysel hayvan çalışmasında biperiden verilen farelerde insanlardakine benzer şekilde davranışsal ve elektroensefalografik değişiklikler ile giden deliryum belirtileri görüldüğü ve bu belirtilerin düşük dozlardan ziyade yüksek dozlarda meydana geldiği belirtilmiştir (6).…”