Biotransformations comparées de benzylisoquinoléines par des suspensions cellulaires végétales non productrices d'alcaloïdes

Centella asiatica (L.) Urban, (Pennywort): Cell Culture, Production of Terpenoids, and Biotransformation Capacity

“…Thus, papaverine was converted to its oxidized derivative, papaveraldine, by a cell suspension culture of C. asiatica. Several other studies have reported biotransformation of papaverine into papaveraldine by plant cell culture: Silene alba, Cardamine pratensis, Digitalis purpurea (Bister-Miel et al 1988), Vinca minor (Podvin 1985), Cinchona succirubra, Ptelea trifoliata, Phaseolus vulgaris, Parthenocissus tricuspidata (Rideau et al 1988), and Glycyrrhiza glabra (Dorisse et al 1988). (Solet 1993) Cell suspension cultures of C. asiatica of Professor Guignard's laboratory have also shown capacity of thiocolchicine demethylation and glucosylation (Fig.…”

Cardamine sp. – A Review on Its Chemical and Biological Profiles

“…Cell suspensions of C. pratensis have been shown to oxidize the benzylisoquinoline alkaloid papaverin into papaveraldin, papaverin N-oxide, and probably berberinium salt, successively [84]. Bioconversion.…”