Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective

Singh, Amit; Singh, Sandeep Kumar; Singh, Prem Pratap; Srivastava, Akhileshwar Kumar; Pandey, Kapil Deo; Kumar, Ajay; Yadav, Himanshu

doi:10.1016/j.btre.2018.e00256

Cited by 23 publications

(16 citation statements)

References 43 publications

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“…Several antioxidant-rich substances have demonstrated gastroprotective effects against ethanol-induced gastric injury [ 26 , 27 ]. Medicinal plants possess a number of biological activities such as anti-oxidant, anti-inflammatory, anti-secretory, and cytoprotective, which collectively protect and heal gastric ulcers through prophylactic and therapeutic mechanisms [ 28 ]. The present study describes the gastroprotective effects of S. fruticosa Forssk.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel

et al. 2022

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Suaeda fruticosa Forssk. Ex J.F.Gmel is traditionally used for inflammatory and digestive disorders, as a carminative, and for diarrhea. This plant is widely distributed in Asia, Africa, and the Mediterranean region. Aqueous methanolic extract of S. fruticosa (Sf.Cr) was prepared and screened for phytoconstituents through qualitative and GC-MS analysis. Quantification of total phenolic and flavonoid contents was performed, while antioxidant capacity was determined by DPPH, CUPRAC, FRAP, and ABTS assays. The gastroprotective activity was assessed in an ethanol-induced ulcer model. Gastric secretory parameters and macroscopic ulcerated lesions were analyzed and scored for ulcer severity. After scoring, histopathology was performed, and gastric mucus contents were determined. Oral pre-treatment of Sf.Cr demonstrated significant gastroprotection. The gastric ulcer severity score and ulcer index were reduced while the %-inhibition of ulcer was increased dose-dependently. The Sf.Cr significantly elevated the pH of gastric juice, while a decrease in total acidity and gastric juice volume was observed. Histopathology demonstrated less oedema and neutrophil infiltration in gastric mucosa of rats pre-treated with the Sf.Cr in comparison to ethanol-intoxicated animals. Furthermore, the gastric mucus contents were increased as determined by alcian blue binding. Sf.Cr showed marked gastroprotective activity, which can be attributed to antioxidant, antisecretory, and cytoprotective effects.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel

et al. 2022

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“…Bromeliaceae é uma família conhecida principalmente por suas características ornamentais e alimentícias (Juvick et al, 2017), não obstante, recentemente têm sido reconhecidas importantes propriedades biotecnológicas de interesse medicinal nesta família (Hernandez et al, 2016;Espinoza et al, 2018;Valles & Cantera, 2018;Singh et al, 2018). Research, Society andDevelopment, v. 9, n. 12, e33091211019, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i12.11019 horas por 14 dias.…”

Section: Discussionunclassified

Atividades biológicas de plantas da família Bromeliaceae e da espécie Encholirium spectabile Mart. ex Schult. & Schult. f.

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Oliveira

et al. 2020

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Bromeliaceae compreende um numeroso grupo de espécies vegetais possuidoras de um vasto potencial biológico, ainda pouco estudado. Diante disto, este estudo teve por objetivo identificar as evidências científicas acerca do potencial biológico de plantas da família Bromeliaceae e da espécie Encholirium spectabile Mart. ex Schult. & Schult. f. Trata-se de uma revisão integrativa da literatura nas bases de dados Scopus, Scifinder, Medline, Web of Science e nas bibliotecas eletrônicas Sciencedirect e Scielo, no período compreendido entre 2013 e 2019. Como resultados, foram selecionados um total de 18 artigos, após aplicação dos critérios de inclusão e exclusão. Dos estudos encontrados, os que foram identificados em maior quantidade estão relacionados a atividade antimicrobiana. Bromelia pinguin, Bromelia laciniosa, Neoglaziovia variegata, Encholirium spectabile, entre outras espécies, apresentaram atividade microbicida frente a bactérias Gram-positivas e Gram-negativas, entre elas Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa e Escherichia coli. Alguns estudos também demonstraram a atividade anti-inflamatória de Bromelia balansae, antiulcerogênica de Ananas ananassoides e antirreumática e antioxidante de Encholirium spectabile. Além das propriedades mencionadas, foi identificado o potencial fotoprotetor, antinociceptivo, antiofídico, anticoagulante entre outras, e foi estabelecida a relação entre estas atividades e a presença de metabólitos secundários. A partir das buscas na literatura foi possível encontrar numerosas pesquisas que respaldam a utilização e o estudo contínuo de plantas como método alternativo às práticas medicinais atuais. Com este estudo, deseja-se contribuir para a ampliação do conhecimento a respeito do potencial biológico da família Bromeliaceae.

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“…Since ancient times, plants/plant parts/natural products (extracts and/or metabolites) have been directly or indirectly utilized in allopathic or Ayurveda to cure various human diseases [1][2][3][4]. According to published records, it has been estimated that approximately 40-50% of total known plant species have been used for medicinal purposes [5,6].…”

Section: Introductionmentioning

confidence: 99%

Algal Metabolites Can Be an Immune Booster against COVID-19 Pandemic

et al. 2022

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The world has faced the challenges of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for the last two years, first diagnosed at the end of 2019 in Wuhan and widely distributed worldwide. As a result, the WHO has proclaimed the illness brought on by this virus to be a global pandemic. To combat COVID-19, researcher communities continuously develop and implement rapid diagnoses, safe and effective vaccinations and other alternative therapeutic procedures. However, synthetic drug-related side effects and high costs have piqued scientists’ interest in natural product-based therapies and medicines. In this regard, antiviral substances derived from natural resources and some medicines have seen a boom in popularity. For instance, algae are a rich source of compounds such as lectins and sulfated polysaccharides, which have potent antiviral and immunity-boosting properties. Moreover, Algae-derived compounds or metabolites can be used as antibodies and vaccine raw materials against COVID-19. Furthermore, some algal species can boost immunity, reduce viral activity in humans and be recommended for usage as a COVID-19 preventative measure. However, this field of study is still in its early stages of development. Therefore, this review addresses critical characteristics of algal metabolites, their antioxidant potential and therapeutic potential in COVID-19.

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Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective

Abstract: Graphical abstract

Cited by 23 publications

References 43 publications

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel

Atividades biológicas de plantas da família Bromeliaceae e da espécie Encholirium spectabile Mart. ex Schult. & Schult. f.

Algal Metabolites Can Be an Immune Booster against COVID-19 Pandemic

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