Biosynthetic preparation of <sup>11</sup>C‐labelled galactose, glycerol and mannitol

Palmer, Anthony J.; Goulding, R.W.

doi:10.1002/jlcr.2590100412

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Galactose was only labeled from position 1 and synthesized using natural plants . The first radiolabeling of galactose with carbon-11 was done as biosynthesis from marine algae (Girgartina stellata).…”

Section: Sugarsmentioning

confidence: 99%

“…The first radiolabeling of galactose with carbon-11 was done as biosynthesis from marine algae (Girgartina stellata). Synthesis was started with [ 11 C]CO 2 and completed in 40 min . Labeled galactose was separated by using LC.…”

Section: Sugarsmentioning

confidence: 99%

“…559 An alternative radiolabeling pathway was developed to directly produce [ 11 Galactose was only labeled from position 1 and synthesized using natural plants. 798 The first radiolabeling of galactose with carbon-11 was done as biosynthesis from marine algae (Girgartina stellata). Synthesis was started with [ 11 C]CO 2 and completed in 40 min.…”

Section: Sugarsmentioning

confidence: 99%

“…Radiosynthesis. The synthesis of [ 11 C]glycerol was achieved by biosynthesis using the algaGirgartina stellata 798. After being exposed to light, the chamber containing the alga was recirculated with a flow of [ 11 C]CO 2 in N 2 for 20 min, allowing the synthesis of [ 11 C]glycerol (35%) and [ 11 C]galactose (65%).…”

mentioning

confidence: 99%

“…After being exposed to light, the chamber containing the alga was recirculated with a flow of [ 11 C]CO 2 in N 2 for 20 min, allowing the synthesis of [ 11 C]glycerol (35%) and [ 11 C]galactose (65%). The mixture of products was extracted with alcohol and separated by liquid chromatography, returning 2.5 MBq of [ 11 C]glycerol with a total processing time of 80−90 min and A m of 1.08 × 10 −4 GBq/μmol 798.…”

mentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

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Section: Sugarsmentioning

confidence: 99%

Section: Sugarsmentioning

confidence: 99%

Section: Sugarsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The synthesis of 6‐deoxy‐6‐¹⁸F‐α‐D‐galactopyranose (XXII)

Christman

Orhanovic

Wolf

1977

Labelled Comp Radiopharmac

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Photosynthetic preparation of galactose‐¹³C₆ and glycerol‐¹³C₃ using a marine red alga

Kollman

Gregg

Whaley

et al. 1979

Labelled Comp Radiopharmac

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t o s y n t h e s i s . The g a l a c t o s i d e was i s o l a t e d from a n a l c o h o l e x t r a c t by an a c e t y l a t i o n p r o c e d u r e and h y d r o l y z e d t o D -g a l a c t o s e and g l y c e r o l . The a v e r a g e e n r i c h m e n t o f t h e i s o l a t e d p r o d u c t s was 5 5 mol % I 3 C w h i l e t h e a c t u a l e n r i c h m e n t o f newly s y n t h e s i z e d m a t e r i a l 2Key Words: G i g a r t i n a , A l g a e , Carbon-13, I3C-nmr, C a r b o h y d r a t e s .

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Biosynthetic preparation of ¹¹C‐labelled galactose, glycerol and mannitol

Cited by 11 publications

References 7 publications

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

The synthesis of 6‐deoxy‐6‐¹⁸F‐α‐D‐galactopyranose (XXII)

Photosynthetic preparation of galactose‐¹³C₆ and glycerol‐¹³C₃ using a marine red alga

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Biosynthetic preparation of 11C‐labelled galactose, glycerol and mannitol

Cited by 11 publications

References 7 publications

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

The synthesis of 6‐deoxy‐6‐18F‐α‐D‐galactopyranose (XXII)

Photosynthetic preparation of galactose‐13C6 and glycerol‐13C3 using a marine red alga

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Biosynthetic preparation of ¹¹C‐labelled galactose, glycerol and mannitol

The synthesis of 6‐deoxy‐6‐¹⁸F‐α‐D‐galactopyranose (XXII)

Photosynthetic preparation of galactose‐¹³C₆ and glycerol‐¹³C₃ using a marine red alga